Monocyte-to-HDL ratio as an inflammatory marker: does it reflect blood pressure patterns?

Ramazan Astan; Ramazan Dayanan

Makale detayları

Monocyte-to-HDL ratio as an inflammatory marker: does it reflect blood pressure patterns?

Yazarlar:

Ramazan Astan | Ramazan Dayanan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.323-327

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357456

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: The monocyte-to-high-density lipoprotein cholesterol ratio MHR has emerged as a novel inflammatory marker associated with cardiovascular risk. Both hypertension HT and non-dipping blood pressure patterns are known to contribute to increased cardiovascular morbidity and mortality. However, the potential association between MHR and circadian blood pressure variations remains unclear. To investigate the relationship between MHR and dipper pattern status, as assessed by 24 hour ambulatory blood pressure monitoring ABPM, in individuals with and without HT. Methods: A total of 160 adults mean age 52.712.1 years; 41.9 male who underwent ABPM were included in the study. Participants were divided into four subgroups based on their hypertensive status and dipping pattern: normotensive dipper, normotensive non-dipper, hypertensive dipper, and hypertensive non-dipper. MHR values were compared among these groups. Due to the non-normal distribution of MHR, statistical analyses were performed using non-parametric methods. Results: No statistically significant difference in MHR was observed between hypertensive and normotensive participants p0.319 or among the four subgroups p0.436. Similarly, there was no significant association between MHR and the dipper pattern across all participants p0.714. Conclusion: MHR does not appear to be associated with hypertensive status or circadian blood pressure variation patterns. Further studies with larger cohorts and longitudinal designs are needed to clarify the potential role of MHR in blood pressure physiology.

 Aims: The monocyte-to-high-density lipoprotein cholesterol ratio MHR has emerged as a novel inflammatory marker associated with cardiovascular risk. Both hypertension HT and non-dipping blood pressure patterns are known to contribute to increased cardiovascular morbidity and mortality. However, the potential association between MHR and circadian blood pressure variations remains unclear. To investigate the relationship between MHR and dipper pattern status, as assessed by 24 hour ambulatory blood pressure monitoring ABPM, in individuals with and without HT. Methods: A total of 160 adults mean age 52.712.1 years; 41.9 male who underwent ABPM were included in the study. Participants were divided into four subgroups based on their hypertensive status and dipping pattern: normotensive dipper, normotensive non-dipper, hypertensive dipper, and hypertensive non-dipper. MHR values were compared among these groups. Due to the non-normal distribution of MHR, statistical analyses were performed using non-parametric methods. Results: No statistically significant difference in MHR was observed between hypertensive and normotensive participants p0.319 or among the four subgroups p0.436. Similarly, there was no significant association between MHR and the dipper pattern across all participants p0.714. Conclusion: MHR does not appear to be associated with hypertensive status or circadian blood pressure variation patterns. Further studies with larger cohorts and longitudinal designs are needed to clarify the potential role of MHR in blood pressure physiology.

 Aims: The monocyte-to-high-density lipoprotein cholesterol ratio MHR has emerged as a novel inflammatory marker associated with cardiovascular risk. Both hypertension HT and non-dipping blood pressure patterns are known to contribute to increased cardiovascular morbidity and mortality. However, the potential association between MHR and circadian blood pressure variations remains unclear. To investigate the relationship between MHR and dipper pattern status, as assessed by 24 hour ambulatory blood pressure monitoring ABPM, in individuals with and without HT. Methods: A total of 160 adults mean age 52.712.1 years; 41.9 male who underwent ABPM were included in the study. Participants were divided into four subgroups based on their hypertensive status and dipping pattern: normotensive dipper, normotensive non-dipper, hypertensive dipper, and hypertensive non-dipper. MHR values were compared among these groups. Due to the non-normal distribution of MHR, statistical analyses were performed using non-parametric methods. Results: No statistically significant difference in MHR was observed between hypertensive and normotensive participants p0.319 or among the four subgroups p0.436. Similarly, there was no significant association between MHR and the dipper pattern across all participants p0.714. Conclusion: MHR does not appear to be associated with hypertensive status or circadian blood pressure variation patterns. Further studies with larger cohorts and longitudinal designs are needed to clarify the potential role of MHR in blood pressure physiology.

 ÖZ Arka plan: Monosit-yüksek yoğunluklu lipoprotein kolesterol oranı MHO, kardiyovasküler riskle ilişkili yeni bir inflamatuar belirteç olarak ortaya çıkmıştır. Hem hipertansiyon hemde non-dipper paternin kardiyovasküler morbidite ve mortalite artışına katkıda bulunduğu bilinmektedir. Ancak, MHO ile sirkadiyen kan basıncı değişimleri arasındaki potansiyel ilişki hala belirsizliğini korumaktadır. Amaç: Hipertsnsiyonu olan ve olmayan bireylerde 24 saatlik ayaktan kan basıncı ölçümü AKBÖ ile değerlendirilen dipper paterni ile MHO arasındaki ilişkiyi araştırmak. Yöntemler: Çalışmaya AKBÖ uygulanan toplam 160 yetişkin ortalama yaş 52,7  12.1 yıl; 41.9 erkek dahil edildi. Katlımcılar hipertansif durumları ve dipper paternlerine göre dört alt gruba ayrıldı;normotansif dipper,normotansif non-dipper,hipertansif dipper,hipertansif dipper olmayan. MHO değerleri bu gruplar arasında karşılaştırıldı. MHOnın normal olmayan dağılımı nedeniyle, istatistiksel analizler parametrik olmayan yöntemler kullanılarak gerçekleştirildi. Bulgular: Hipertansif ve normotansif katılımcılar p:0.319 veya dört alt grup p:0.436 arasında MHOda istatistiksel olarak anlamlı bir fark izlenmedi. Benzer şekilde, tüm katılımcılar arasında MHO ile dipper paterni arasında anlamlı bir ilişki yoktu p:0,714. Sonuç: MHOnın hipertansif durum veya sirkadiyen kan basıncı varyasyon paternleriyle ilişkili görünmemektedir. MHOnın kan basıncı fizyolojisindeki potansiyel rolünü açılığa kavuşturmak için daha büyük kohortlar ve uzunlamasına tasarımlarla daha fazla çalışmaya ihtiyaç vardır.

Makale detayları

Monocyte-to-HDL ratio as an inflammatory marker: does it reflect blood pressure patterns?

Yazarlar:

Ramazan Astan | Ramazan Dayanan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.323-327

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357456

pISSN:

2717-7505

Monocyte to HDL cholesterol ratio

ambulatory blood pressure monitoring

hypertension

dipper pattern

non dipper patternMonosit-HDL oanı

Ambulatuar Kan Basıncı

Hipertansiyon

Dipper

Dipper Olmayan

Sayı

Makale detayları

Yazarlar: Ramazan Astan | Ramazan Dayanan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kardiyoloji

Dergi: Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.323-327

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357456

pISSN: 2717-7505

Sayı

Yazarlar:

Ramazan Astan | Ramazan Dayanan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.323-327

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357456

pISSN:

2717-7505