Investigation of Cephalosporin and Heavy Metal Resistance of Aeromonas hydrophila and Pseudomonas aeruginosa Strains Isolated from Hospital Sewage in Türkiye

Fatih Matyar

Makale detayları

Investigation of Cephalosporin and Heavy Metal Resistance of Aeromonas hydrophila and Pseudomonas aeruginosa Strains Isolated from Hospital Sewage in Türkiye

Yazarlar:

Fatih Matyar

Yayıncı:

Isparta University of Applied Sciences

Ana Başlıklar:

Yapısal Biyoloji

Dergi:

Acta Aquatica Turcica Vol.19 Issue 4, pp.312-322

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303835

pISSN:

2651-5474

Anahtar kelimeler:

Özet:

 In this study, 89 strains of Aeromonas hydrophila and 88 strains of Pseudomonas aeruginosa were isolated from the sewage of a university hospital in Turkey. The resistance of these bacterial isolates to 11 different cephalosporin classes antibiotics belonging to four generations and to 4 heavy metals was investigated. Cadmium, lead, manganese, and zinc are the heavy metals employed. There was a high incidence of resistance to cefazolin 98.9, cefaclor 98.9, and cefprozil 97.8 among the A. hydrophila isolates. Lower resistance to cefoxitin 30.3, cefepime 30.3, and ceftazidime 31.4 were found. Cefazolin, cefuroxime, cefaclor, and cefoxitin resistance was found to be 100 among the P. aeruginosa isolates. Moreover, resistance rates to cefprozil 98.9, cefixime 96.6, and ceftizoxime 85.2 were detected. No isolates of P. aeruginosa were showed resistance to ceftazidime, cefepime and cefpirome. Multiple antibiotic resistance MAR indexes ranged from 0.27 to 1.0 among A. hydrophila isolates and from 0.46 to 0.72 among P. aeruginosa isolates. All of the A. hydrophila and P. aeruginosa isolates showed resistance to cadmium. A. hydrophila and P. aeruginosa isolates showed low resistance to lead of 6.7 and 2.2 respectively. Results indicate that both species are easily recovered in hospital sewage and these species gained resistance to different generations of cephalosporins and heavy metals.

 In this study, 89 strains of Aeromonas hydrophila and 88 strains of Pseudomonas aeruginosa were isolated from the sewage of a university hospital in Turkey. The resistance of these bacterial isolates to 11 different cephalosporin classes antibiotics belonging to four generations and to 4 heavy metals was investigated. Cadmium, lead, manganese, and zinc are the heavy metals employed. There was a high incidence of resistance to cefazolin 98.9, cefaclor 98.9, and cefprozil 97.8 among the A. hydrophila isolates. Lower resistance to cefoxitin 30.3, cefepime 30.3, and ceftazidime 31.4 were found. Cefazolin, cefuroxime, cefaclor, and cefoxitin resistance was found to be 100 among the P. aeruginosa isolates. Moreover, resistance rates to cefprozil 98.9, cefixime 96.6, and ceftizoxime 85.2 were detected. No isolates of P. aeruginosa were showed resistance to ceftazidime, cefepime and cefpirome. Multiple antibiotic resistance MAR indexes ranged from 0.27 to 1.0 among A. hydrophila isolates and from 0.46 to 0.72 among P. aeruginosa isolates. All of the A. hydrophila and P. aeruginosa isolates showed resistance to cadmium. A. hydrophila and P. aeruginosa isolates showed low resistance to lead of 6.7 and 2.2 respectively. Results indicate that both species are easily recovered in hospital sewage and these species gained resistance to different generations of cephalosporins and heavy metals.

 In this study, 89 strains of Aeromonas hydrophila and 88 strains of Pseudomonas aeruginosa were isolated from the sewage of a university hospital in Turkey. The resistance of these bacterial isolates to 11 different cephalosporin classes antibiotics belonging to four generations and to 4 heavy metals was investigated. Cadmium, lead, manganese, and zinc are the heavy metals employed. There was a high incidence of resistance to cefazolin 98.9, cefaclor 98.9, and cefprozil 97.8 among the A. hydrophila isolates. Lower resistance to cefoxitin 30.3, cefepime 30.3, and ceftazidime 31.4 were found. Cefazolin, cefuroxime, cefaclor, and cefoxitin resistance was found to be 100 among the P. aeruginosa isolates. Moreover, resistance rates to cefprozil 98.9, cefixime 96.6, and ceftizoxime 85.2 were detected. No isolates of P. aeruginosa were showed resistance to ceftazidime, cefepime and cefpirome. Multiple antibiotic resistance MAR indexes ranged from 0.27 to 1.0 among A. hydrophila isolates and from 0.46 to 0.72 among P. aeruginosa isolates. All of the A. hydrophila and P. aeruginosa isolates showed resistance to cadmium. A. hydrophila and P. aeruginosa isolates showed low resistance to lead of 6.7 and 2.2 respectively. Results indicate that both species are easily recovered in hospital sewage and these species gained resistance to different generations of cephalosporins and heavy metals.

 Bu çalışmada Türkiyede bir üniversite hastane kanalizasyonundan 89 adet Aeromonas hydrophila ve 88 adet Pseudomonas aeruginosa suşu izole edilmiştir. Bu bakteriyal izolatların dört kuşağa ait 11 farklı sınıf sefalosporin antibiyotiğine ve 4 farklı ağır metale karşı dirençliliği araştırılmıştır. Kullanılan ağır metaller kadmiyum, kurşun, manganez ve çinkodur. A. hydrophila izolatları arasında sefazoline 98,9, sefaklora 98,9 ve sefprozile 97,8 karşı yüksek insidansta dirençlilik bulunmuştur. Sefoksitin 30,3, sefepim 30,3 ve saftazidime 31,4, karşı dirençlilik daha düşük bulunmuştur. P. aeruginosa izolatları arasında sefazoline, sefuroksime, sefaklora ve sefoksitine dirençlilik 100 olarak bulunmuştur. Ayrıca, sefprozile 98,7, sefiksime 96,6 ve seftizoksime 85,2, oranında karşı dirençlilik tespit edilmiştir. Hiçbir P. aeruginosa izolatı seftazidim, sefepim ve sefpiroma karşı dirençlilik göstermemiştir. A. hydrophila izolatları arasında çoklu antibiyotik dirençliliği ÇAD indeksi 0,27 den 1,0e kadar ve P. aeruginosa ÇAD indeksi 0,46dan 0,72 aralığında değişiklik göstermiştir. Tüm A. hydrophila ve P. aeruginosa izolatları kadmiyuma karşı dirençlilik göstermiştir. A. hydrophila ve P. aeruginosa izolatları kurşuna karşı sırasıyla 6,7 ve 2,2 oranında düşük dirençlilik göstermişlerdir. Sonuçlar her iki türün de hastane kanalizasyonundan kolaylıkla izole edilebildiğini ve bu türlerin farklı kuşak sefalosporinlere ve ağır metallere karşı dirençlilik kazandığını göstermektedir.

Makale detayları

Investigation of Cephalosporin and Heavy Metal Resistance of Aeromonas hydrophila and Pseudomonas aeruginosa Strains Isolated from Hospital Sewage in Türkiye

Yazarlar:

Fatih Matyar

Yayıncı:

Isparta University of Applied Sciences

Ana Başlıklar:

Yapısal Biyoloji

Dergi:

Acta Aquatica Turcica Vol.19 Issue 4, pp.312-322

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303835

pISSN:

2651-5474

Aeromonas hydrophila

Pseudomonas aeruginosa

Antibiotic resistance

Heavy metal resistanceAeromonas hydrophila

Pseudomonas aeruginosa

Antibiyotik dirençliliği

Ağır metal dirençliliği

Sayı

Makale detayları

Yazarlar: Fatih Matyar

Yayıncı: Isparta University of Applied Sciences

Ana Başlıklar: Yapısal Biyoloji

Dergi: Acta Aquatica Turcica Vol.19 Issue 4, pp.312-322

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001303835

pISSN: 2651-5474

Sayı

Yazarlar:

Fatih Matyar

Yayıncı:

Isparta University of Applied Sciences

Ana Başlıklar:

Yapısal Biyoloji

Dergi:

Acta Aquatica Turcica Vol.19 Issue 4, pp.312-322

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303835

pISSN:

2651-5474