Comparative efficacy of non-invasive ventilation methods in managing neonatal pneumonia: a clinical outcome study

Aybüke Yazıcı; Sevim Ünal

Makale detayları

Comparative efficacy of non-invasive ventilation methods in managing neonatal pneumonia: a clinical outcome study

Yazarlar:

Aybüke Yazıcı | Sevim Ünal

Yayıncı:

Cukurova University

Ana Başlıklar:

Yenidoğan

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.1057-1066

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329062

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study was was to compare the effectiveness and outcomes of non-invasive ventilation NIV methods in neonates diagnosed with lower respiratory tract infections LRTI. Materials and Methods: A prospective study was conducted in neonates with LRTI treated with high-flow nasal cannula HFNC, nasal continuous positive airway pressure NCPAP, or nasal intermittent positive pressure ventilation NIPPV in the neonatal intensive care unit. Method failure was defined as switching to another NIV method within 6 hours based on clinical and laboratory findings. The groups were compared for clinical and laboratory findings, length of hospital stay, outcomes, success rates, and complications. Results: One hundred and six neonates were included with a median gestational age of 38 weeks and birth weight of 2991673 g. Downes scores at admission were significantly higher in the NCPAP group than in the others. The HFNC group had better of blood pH and CO2 levels but had a higher rate of treatment failure. NCPAP was associated with the highest success rate 86.8, followed by NIPPV 78.7 and HFNC 52.4. The length of hospital stay was shorter in patients successfully treated with NCPAP and NIPPV. According to the logistic regression analysis, NIPPV significantly reduced the risk of failure compared to HFNC. Conclusion: NIPPV and NCPAP were more effective than HFNC in the management of neonatal LRTI with shorter hospital stay. HFNC may be effective in stabilizing baseline respiratory parameters in the management of neonatal LRTI.

 Purpose: The aim of this study was was to compare the effectiveness and outcomes of non-invasive ventilation NIV methods in neonates diagnosed with lower respiratory tract infections LRTI. Materials and Methods: A prospective study was conducted in neonates with LRTI treated with high-flow nasal cannula HFNC, nasal continuous positive airway pressure NCPAP, or nasal intermittent positive pressure ventilation NIPPV in the neonatal intensive care unit. Method failure was defined as switching to another NIV method within 6 hours based on clinical and laboratory findings. The groups were compared for clinical and laboratory findings, length of hospital stay, outcomes, success rates, and complications. Results: One hundred and six neonates were included with a median gestational age of 38 weeks and birth weight of 2991673 g. Downes scores at admission were significantly higher in the NCPAP group than in the others. The HFNC group had better of blood pH and CO2 levels but had a higher rate of treatment failure. NCPAP was associated with the highest success rate 86.8, followed by NIPPV 78.7 and HFNC 52.4. The length of hospital stay was shorter in patients successfully treated with NCPAP and NIPPV. According to the logistic regression analysis, NIPPV significantly reduced the risk of failure compared to HFNC. Conclusion: NIPPV and NCPAP were more effective than HFNC in the management of neonatal LRTI with shorter hospital stay. HFNC may be effective in stabilizing baseline respiratory parameters in the management of neonatal LRTI.

 Purpose: The aim of this study was was to compare the effectiveness and outcomes of non-invasive ventilation NIV methods in neonates diagnosed with lower respiratory tract infections LRTI. Materials and Methods: A prospective study was conducted in neonates with LRTI treated with high-flow nasal cannula HFNC, nasal continuous positive airway pressure NCPAP, or nasal intermittent positive pressure ventilation NIPPV in the neonatal intensive care unit. Method failure was defined as switching to another NIV method within 6 hours based on clinical and laboratory findings. The groups were compared for clinical and laboratory findings, length of hospital stay, outcomes, success rates, and complications. Results: One hundred and six neonates were included with a median gestational age of 38 weeks and birth weight of 2991673 g. Downes scores at admission were significantly higher in the NCPAP group than in the others. The HFNC group had better of blood pH and CO2 levels but had a higher rate of treatment failure. NCPAP was associated with the highest success rate 86.8, followed by NIPPV 78.7 and HFNC 52.4. The length of hospital stay was shorter in patients successfully treated with NCPAP and NIPPV. According to the logistic regression analysis, NIPPV significantly reduced the risk of failure compared to HFNC. Conclusion: NIPPV and NCPAP were more effective than HFNC in the management of neonatal LRTI with shorter hospital stay. HFNC may be effective in stabilizing baseline respiratory parameters in the management of neonatal LRTI.

 Amaç: Bu çalışmada alt solunum yolu enfeksiyonu ASYE tanısı konulan yenidoğanlarda noninvaziv ventilasyon NMV yöntemlerinin etkinliğini ve sonuçlarını karşılaştırmayı amaçladık. Gereç ve Yöntem: Yenidoğan yoğun bakım ünitesinde yüksek akışlı nazal kanül HFNC, nazal sürekli pozitif hava yolu basıncı NCPAP veya nazal aralıklı pozitif basınçlı ventilasyon NIPPV ile tedavi edilen ASYElu yenidoğanlarda prospektif bir çalışma yürütüldü. Yöntemin başarısızlığı, klinik ve laboratuvar bulgularına göre 6 saat içinde başka bir NIV yöntemine geçmek olarak tanımlandı. Gruplar klinik ve laboratuvar bulguları, hastanede kalış süresi, sonuçlar, başarı oranları ve komplikasyonlar açısından karşılaştırıldı. Bulgular: Çalışmaya medyan gebelik yaşı 38 hafta ve doğum ağırlığı 2991673 g olan toplam 106 yenidoğan dahil edildi. Kabuldeki Downes skorları NCPAP grubunda diğerlerinden anlamlı olarak daha yüksekti. HFNC grubunda kan pH ve CO2 seviyelerinde daha iyi sonuçlar saptanmasına rağmen daha yüksek oranda tedavi başarısızlığı görüldü. NCPAP en yüksek başarı oranıyla 86.8 ilişkiliydi, bunu NIPPV 78.7 ve HFNC 52.4 izledi. NCPAP ve NIPPV ile başarılı bir şekilde tedavi edilen hastaların hastanede kalış süreleri daha kısaydı. Lojistik regresyon analizine göre NIPPV HFNC ile karşılaştırıldığında başarısızlık riskini anlamlı şekilde azalttı. Sonuç: NIPPV ve NCPAP, daha kısa hastane yatışıyla neonatal ASYEnu yönetmede HFNCden daha etkiliydi. Neonatal ASYEnda, HFNC bazal solunum parametrelerini stabilize etmede etkili olabilir.

Makale detayları

Comparative efficacy of non-invasive ventilation methods in managing neonatal pneumonia: a clinical outcome study

Yazarlar:

Aybüke Yazıcı | Sevim Ünal

Yayıncı:

Cukurova University

Ana Başlıklar:

Yenidoğan

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.1057-1066

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329062

pISSN:

2602-3032

Newborn

lower respiratory tract infection

non-invasive ventilation

high-flow nasal cannula

nasal CPAP

nasal IPPV.Yüksek akışlı nazal kanül

alt solunum yolu enfeksiyonu

nazal CPAP

nazal IPPV

yenidoğan

non-invaziv ventilasyon

Sayı

Makale detayları

Yazarlar: Aybüke Yazıcı | Sevim Ünal

Yayıncı: Cukurova University

Ana Başlıklar: Yenidoğan

Dergi: Cukurova Medical Journal Vol.49 Issue 4, pp.1057-1066

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001329062

pISSN: 2602-3032

Sayı

Yazarlar:

Aybüke Yazıcı | Sevim Ünal

Yayıncı:

Cukurova University

Ana Başlıklar:

Yenidoğan

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.1057-1066

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329062

pISSN:

2602-3032