Synthesis, reaction, and evaluation of the anticancer activity of   6,7,8,9-tetrahydro-5HHH-cyclohepta[4,5]selenopheno[2,3-ddd]pyrimidine derivatives

Kadir DOĞANAY; Ünzile KELEŞTEMUR; Sevgi BALCIOĞLU; Burhan ATEŞ; Aliye ALTUNDAŞ

Makale detayları

Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5HHH-cyclohepta[4,5]selenopheno[2,3-ddd]pyrimidine derivatives

Yazarlar:

Kadir DOĞANAY | Ünzile KELEŞTEMUR | Sevgi BALCIOĞLU | Burhan ATEŞ | Aliye ALTUNDAŞ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 4, pp.631-640

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000726586

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The cyclocondensation of   2-amino-5,6,7,8-tetrahydro-4HHH-cyclohepta[bbb] selenophene-3-carbonitrile (1) with formic acid and formamide gave the selenophenopyrimidine   15 and selenophenopyrimidone 6 derivatives. The reaction   of 6 with phosphorus oxychloride produced   4-chloro-6,7,8,9-tetrahydro-5HHH-cyclohepta[4,5] seleno[2,3-ddd]pyrimidine   (12), the key compound for our nucleophilic substitution reactions.   The hydrazinoselenophenopyrimidine 19 obtained from the reaction of   12 with hydrazine hydrate was converted to its   tetrazoloselenophenopyrimidine 21 and triazoloselenophenopyrimidine   26 derivatives. Moreover, the chloropyrimidine derivative was   reacted with pyrrolidine and morpholine to afford   4-(1-pyrrolidinyl)-6,7,8,9-tetrahydro-5HHH-cylohepta[4,5]selenopheno[2,3-ddd]pyrimidine   (27) and   4-(6,7,8,9-tetrahydro-5HHH-cyclohepta[4,5]selenopheno[2,3-ddd]pirimidin-4-yl)morpholine   (28). Anticancer activities of the synthesized compounds were   investigated against the MCF-7 breast cancer cell line and the IC5050_{50}   values of these compounds were in the range of 70.86--250.06 μμ\mu M.

Makale detayları

Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5HHH-cyclohepta[4,5]selenopheno[2,3-ddd]pyrimidine derivatives

Yazarlar: Kadir DOĞANAY | Ünzile KELEŞTEMUR | Sevgi BALCIOĞLU | Burhan ATEŞ | Aliye ALTUNDAŞ

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2016 Vol.40 Issue 4, pp.631-640

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000726586

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Kadir DOĞANAY | Ünzile KELEŞTEMUR | Sevgi BALCIOĞLU | Burhan ATEŞ | Aliye ALTUNDAŞ

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 4, pp.631-640

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000726586

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527