Effects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking

Mostafa TAHA; Mohamed BADAWY; Reda ABDEL-RAZİK; Hassan YOUNİS; Mahmoud ABO-EL-SAAD

doi:https://doi.org/10.37212/jcnos.1080039

Makale detayları

Effects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking

Yazarlar:

Mostafa TAHA | Mohamed BADAWY | Reda ABDEL-RAZİK | Hassan YOUNİS | Mahmoud ABO-EL-SAAD

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2021 Vol.13 Issue 3

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000708671

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.1080039

Özet:

 

The present study evaluated the adverse effects of three widely used insecticides in the Egyptian environment on mitochondrial bioenergetic and oxidative stress biomarkers in the rat kidney. Chlorpyrifos, cypermethrin, and imidacloprid were orally administrated to male albino rats at 1/50 of the LD50 for 28 days by 5 doses /week. The insecticides caused a significant in vivo decrease in the activities of mitochondrial bioenergetic biomarkers; NADH dehydrogenase, adenosine triphosphatase (ATPase) and mitochondrial oxidative stress biomarkers; superoxide dismutase (SOD), and glutathione S- transferase (GST) while the malondialdehyde (MDA) and protein carbonyl contents (PCC) were significantly increased. Further, chromatography analysis demonstrated that 8-hydroxy-2'-deoxyguanosine (8-OH-2DG) increased considerably in rat urine as a DNA damage biomarker. The kidney deficiency was confirmed by histological examination and in silico simulation analysis (Molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET)). The alterations in the tested parameters were confirmed by the symptoms of histological deformation in kidney tissues, demonstrating the hazardous effects. The laboratory results showed the impact of the tested insecticides in conformity with the in silico simulation analysis (molecular docking and ADMET).

Makale detayları

Effects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking

Yazarlar: Mostafa TAHA | Mohamed BADAWY | Reda ABDEL-RAZİK | Hassan YOUNİS | Mahmoud ABO-EL-SAAD

Yayıncı: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Journal of Cellular Neuroscience and Oxidative Stress 2021 Vol.13 Issue 3

Belge Tipi: Makale

Yayın Tarihi: 4/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000708671

Sıklık: Üç Yıllık

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.1080039

Sayı

Yazarlar:

Mostafa TAHA | Mohamed BADAWY | Reda ABDEL-RAZİK | Hassan YOUNİS | Mahmoud ABO-EL-SAAD

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2021 Vol.13 Issue 3

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000708671

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.1080039