Insights to the phase solubility diagrams of flurbiprofen with inclusion complex

N.A.

Makale detayları

Insights to the phase solubility diagrams of flurbiprofen with inclusion complex

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.196-208

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347811

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Flurbiprofen FB is one of the nonsteroidal anti-inflammatory drugs with poor water solubility. Cyclodextrins have a special structure hydrophobic inner phase and hydrophilic outer phase, which have been widely used to enhance the solubility and stability of drug substances in pharmaceutical applications. The present study is intended to improve the solubility of FB with the inclusion complexes assembled by using beta-cyclodextrin β-CD and hydroxypropyl beta-cyclodextrin HPβ-CD and to perform the phase solubility studies to estimate the stability constant and complexation efficiency. The results of phase solubility studies showed that the FBβ-CD complexes have Bs type and FBHPβ-CD complexes have AL type profiles in both PBS and water media. The interaction forces between FB and HPβ-CD were stronger than FB and β-CD for the formation of inclusion complex in water. Moreover, the complexation efficiency value of FBHPβ-CD complex in water media was found higher than the FBHPβ-CD complex in PBS media. These results of phase solubility studies absolutely demonstrated the advantage of HPβ-CD instead of β-CD to obtain the inclusion complex with 1:1 Molar ratio in water and to improve the apparent water solubility of FB. According to these results, the FBHPβ-CD inclusion complex was prepared with the Freeze-drying method and it was achieved to enhance the water solubility of FB 52.6-fold with using HPβ-CD. In conclusion, the presence of the inclusion complex was successfully confirmed by differential scattering calorimetry, X-ray diffraction, scanning electron microscopy and fourier transform infrared analysis.

 Flurbiprofen FB is one of the nonsteroidal anti-inflammatory drugs with poor water solubility. Cyclodextrins have a special structure hydrophobic inner phase and hydrophilic outer phase, which have been widely used to enhance the solubility and stability of drug substances in pharmaceutical applications. The present study is intended to improve the solubility of FB with the inclusion complexes assembled by using beta-cyclodextrin β-CD and hydroxypropyl beta-cyclodextrin HPβ-CD and to perform the phase solubility studies to estimate the stability constant and complexation efficiency. The results of phase solubility studies showed that the FBβ-CD complexes have Bs type and FBHPβ-CD complexes have AL type profiles in both PBS and water media. The interaction forces between FB and HPβ-CD were stronger than FB and β-CD for the formation of inclusion complex in water. Moreover, the complexation efficiency value of FBHPβ-CD complex in water media was found higher than the FBHPβ-CD complex in PBS media. These results of phase solubility studies absolutely demonstrated the advantage of HPβ-CD instead of β-CD to obtain the inclusion complex with 1:1 Molar ratio in water and to improve the apparent water solubility of FB. According to these results, the FBHPβ-CD inclusion complex was prepared with the Freeze-drying method and it was achieved to enhance the water solubility of FB 52.6-fold with using HPβ-CD. In conclusion, the presence of the inclusion complex was successfully confirmed by differential scattering calorimetry, X-ray diffraction, scanning electron microscopy and fourier transform infrared analysis.

 Flurbiprofen FB is one of the nonsteroidal anti-inflammatory drugs with poor water solubility. Cyclodextrins have a special structure hydrophobic inner phase and hydrophilic outer phase, which have been widely used to enhance the solubility and stability of drug substances in pharmaceutical applications. The present study is intended to improve the solubility of FB with the inclusion complexes assembled by using beta-cyclodextrin β-CD and hydroxypropyl beta-cyclodextrin HPβ-CD and to perform the phase solubility studies to estimate the stability constant and complexation efficiency. The results of phase solubility studies showed that the FBβ-CD complexes have Bs type and FBHPβ-CD complexes have AL type profiles in both PBS and water media. The interaction forces between FB and HPβ-CD were stronger than FB and β-CD for the formation of inclusion complex in water. Moreover, the complexation efficiency value of FBHPβ-CD complex in water media was found higher than the FBHPβ-CD complex in PBS media. These results of phase solubility studies absolutely demonstrated the advantage of HPβ-CD instead of β-CD to obtain the inclusion complex with 1:1 Molar ratio in water and to improve the apparent water solubility of FB. According to these results, the FBHPβ-CD inclusion complex was prepared with the Freeze-drying method and it was achieved to enhance the water solubility of FB 52.6-fold with using HPβ-CD. In conclusion, the presence of the inclusion complex was successfully confirmed by differential scattering calorimetry, X-ray diffraction, scanning electron microscopy and fourier transform infrared analysis.

 Flurbiprofen FB is one of the nonsteroidal anti-inflammatory drugs with poor water solubility. Cyclodextrins have a special structure hydrophobic inner phase and hydrophilic outer phase, which have been widely used to enhance the solubility and stability of drug substances in pharmaceutical applications. The present study is intended to improve the solubility of FB with the inclusion complexes assembled by using beta-cyclodextrin β-CD and hydroxypropyl beta-cyclodextrin HPβ-CD and to perform the phase solubility studies to estimate the stability constant and complexation efficiency. The results of phase solubility studies showed that the FBβ-CD complexes have Bs type and FBHPβ-CD complexes have AL type profiles in both PBS and water media. The interaction forces between FB and HPβ-CD were stronger than FB and β-CD for the formation of inclusion complex in water. Moreover, the complexation efficiency value of FBHPβ-CD complex in water media was found higher than the FBHPβ-CD complex in PBS media. These results of phase solubility studies absolutely demonstrated the advantage of HPβ-CD instead of β-CD to obtain the inclusion complex with 1:1 Molar ratio in water and to improve the apparent water solubility of FB. According to these results, the FBHPβ-CD inclusion complex was prepared with the Freeze-drying method and it was achieved to enhance the water solubility of FB 52.6-fold with using HPβ-CD. In conclusion, the presence of the inclusion complex was successfully confirmed by differential scattering calorimetry, X-ray diffraction, scanning electron microscopy and fourier transform infrared analysis.

Makale detayları

Insights to the phase solubility diagrams of flurbiprofen with inclusion complex

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.196-208

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347811

pISSN:

2630-6344

Flurbiprofen

phase solubility

cyclodextrins

inclusion complex

freeze-drying.

Sayı

Makale detayları

Insights to the phase solubility diagrams of flurbiprofen with inclusion complex

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies | Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.25 Issue 2, pp.196-208

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347811

pISSN: 2630-6344

Flurbiprofen

phase solubility

cyclodextrins

inclusion complex

freeze-drying.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies | Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.196-208

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347811

pISSN:

2630-6344