Determining the levels of serum Heat Shock Protein B7 (HSPB7) and tetranectin in patients undergoing hemodialysis

Özgen Kılıç Erkek; Gülşah Gündoğdu; Davut Akın; Mehmet Alpua; Dilek Sayın; Z. Melek Bor Küçükatay

Makale detayları

Determining the levels of serum Heat Shock Protein B7 (HSPB7) and tetranectin in patients undergoing hemodialysis

Yazarlar:

Özgen Kılıç Erkek | Gülşah Gündoğdu | Davut Akın | Mehmet Alpua | Dilek Sayın | Z. Melek Bor Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.337-345

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300685

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: Heart damage may develop over time in patients with chronic renal disease CKD, who are undergoing hemodialysis HD treatment. Serum levels of heat shock protein B7 HSPB7 and tetranectin proteins change following damage to the heart muscle. This study aimed to determine HSPB7 and tetranectin levels in patients with CKD undergoing HD treatment. Materials and methods: The patients aged 30-60 years old, healthy controls n30 and HD patients n30 participated in the study. Blood samples were taken from healthy subjects who applied to the hospital for check-up and from patients with kidney disease receiving HD treatment. Biochemical parameters were examined from the blood taken. HSPB7 and tetranectin levels from isolated serum samples were determined using measurement kits based on the solid phase sandwich ELISA principle. Results: There was no significant difference between the groups in gender, age, glucose and iron Fe values of the subjects p0.05. Lymphocyte, platelet counts, hemoglobin and albumin values were found to be lower in patient group compared to the control group p0.05. Urea, creatine kinase CK and C-reactive protein CRP values were found to be higher in patient group than in the control group p0.05. A significant increase in HSPB7 levels and a significant decrease in tetranectin levels were detected in patient group compared to control group p0.001. Conclusions: In this study, the changes detected in HSPB7 and tetranectin levels in with CKD undergoing HD treatment. May be early indicators of the possible development of cardiovascular diseases in patients with renal disease.

 Purpose: Heart damage may develop over time in patients with chronic renal disease CKD, who are undergoing hemodialysis HD treatment. Serum levels of heat shock protein B7 HSPB7 and tetranectin proteins change following damage to the heart muscle. This study aimed to determine HSPB7 and tetranectin levels in patients with CKD undergoing HD treatment. Materials and methods: The patients aged 30-60 years old, healthy controls n30 and HD patients n30 participated in the study. Blood samples were taken from healthy subjects who applied to the hospital for check-up and from patients with kidney disease receiving HD treatment. Biochemical parameters were examined from the blood taken. HSPB7 and tetranectin levels from isolated serum samples were determined using measurement kits based on the solid phase sandwich ELISA principle. Results: There was no significant difference between the groups in gender, age, glucose and iron Fe values of the subjects p0.05. Lymphocyte, platelet counts, hemoglobin and albumin values were found to be lower in patient group compared to the control group p0.05. Urea, creatine kinase CK and C-reactive protein CRP values were found to be higher in patient group than in the control group p0.05. A significant increase in HSPB7 levels and a significant decrease in tetranectin levels were detected in patient group compared to control group p0.001. Conclusions: In this study, the changes detected in HSPB7 and tetranectin levels in with CKD undergoing HD treatment. May be early indicators of the possible development of cardiovascular diseases in patients with renal disease.

 Purpose: Heart damage may develop over time in patients with chronic renal disease CKD, who are undergoing hemodialysis HD treatment. Serum levels of heat shock protein B7 HSPB7 and tetranectin proteins change following damage to the heart muscle. This study aimed to determine HSPB7 and tetranectin levels in patients with CKD undergoing HD treatment. Materials and methods: The patients aged 30-60 years old, healthy controls n30 and HD patients n30 participated in the study. Blood samples were taken from healthy subjects who applied to the hospital for check-up and from patients with kidney disease receiving HD treatment. Biochemical parameters were examined from the blood taken. HSPB7 and tetranectin levels from isolated serum samples were determined using measurement kits based on the solid phase sandwich ELISA principle. Results: There was no significant difference between the groups in gender, age, glucose and iron Fe values of the subjects p0.05. Lymphocyte, platelet counts, hemoglobin and albumin values were found to be lower in patient group compared to the control group p0.05. Urea, creatine kinase CK and C-reactive protein CRP values were found to be higher in patient group than in the control group p0.05. A significant increase in HSPB7 levels and a significant decrease in tetranectin levels were detected in patient group compared to control group p0.001. Conclusions: In this study, the changes detected in HSPB7 and tetranectin levels in with CKD undergoing HD treatment. May be early indicators of the possible development of cardiovascular diseases in patients with renal disease.

 gelişebilmektedir. Isı şok proteini B7 HSPB7 ve tetranektin proteinlerinin serum düzeyleri kalp kasında gelişen hasarı takiben değişmektedir. Bu çalışmada, HD tedavisi alan KBH hastalarında HSPB7 ve tetranektin düzeylerinin araştırılması amaçlanmıştır. Gereç ve yöntem: Çalışmaya 30-60 yaş, sağlıklı ve HD hastası denekler katılmış olup iki grup oluşturulmuştur n60: Kontrol grubu n30 ve Hasta grubu n30. Hastaneye check-up için başvuran sağlıklı deneklerden ve böbrek hastalığı olup HD tedavisi alan hastalardan kan örnekleri alınmıştır. Alınan kanlardan biyokimyasal parametreler incelenmiştir. İzole edilen serum örneklerinden HSPB7 ve tetranektin düzeyleri solid faz sandwich ELİSA prensibine dayanan ölçüm kitleri kullanılarak belirlenmiştir. Bulgular: Deneklerin cinsiyet, yaş, glukoz ve Demir Fe değerlerinde gruplar arasında anlamlı fark saptanmamıştır p0,05. Lenfosit, trombosit sayıları, hemoglobin ve albümin değerleri diyaliz hastalarında kontrol grubuna kıyasla düşük bulunmuştur p0,05. Diyaliz hastalarında üre, kreatin kinaz ve CRP değerleri sağlıklı kontrol grubuna göre yüksek saptanmıştır p0,05. Hastalarda sağlıklı deneklere kıyasla, HSPB7 düzeylerinde anlamlı artış ve tetranektin düzeylerinde ise anlamlı düşüş tespit edilmiştir p0,001. Sonuç: Bu çalışmada, diyaliz tedavisi alan KBH hastalarında HSPB7 ve tetranektin düzeylerinde tespit edilen değişimler, böbrek yetmezliği olan hastalarda olası gelişebilecek kardiyovasküler hastalıkların gelişiminin erken göstergesi olabilir.

Makale detayları

Determining the levels of serum Heat Shock Protein B7 (HSPB7) and tetranectin in patients undergoing hemodialysis

Yazarlar:

Özgen Kılıç Erkek | Gülşah Gündoğdu | Davut Akın | Mehmet Alpua | Dilek Sayın | Z. Melek Bor Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.337-345

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300685

pISSN:

1308-0865

Hemodialysis

chronic renal disease (CKD)

HSPB7

tetranectinHemodiyaliz

kronik böbrek hastalığı (KBH)

HSPB7

tetranektin

Sayı

Makale detayları

Yazarlar: Özgen Kılıç Erkek | Gülşah Gündoğdu | Davut Akın | Mehmet Alpua | Dilek Sayın | Z. Melek Bor Küçükatay

Yayıncı: Pamukkale University

Ana Başlıklar: İç Hastalıkları

Dergi: Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.337-345

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001300685

pISSN: 1308-0865

Sayı

Yazarlar:

Özgen Kılıç Erkek | Gülşah Gündoğdu | Davut Akın | Mehmet Alpua | Dilek Sayın | Z. Melek Bor Küçükatay

Yayıncı:

Pamukkale University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.337-345

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300685

pISSN:

1308-0865