The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity

Soner Yeşilyurt; Osman Erinç; Türker Demirtakan; Almila Şenat; Esra Fırat Oğuz; Nihat Mujdat Hokenek; Özcan Erel

Makale detayları

The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity

Yazarlar:

Soner Yeşilyurt | Osman Erinç | Türker Demirtakan | Almila Şenat | Esra Fırat Oğuz | Nihat Mujdat Hokenek | Özcan Erel

Yayıncı:

Sakarya University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları | Klinik Kimya

Dergi:

Sakarya Tıp Dergisi Vol.15 Issue 3, pp.218-226

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358008

pISSN:

2146-409X

Anahtar kelimeler:

Özet:

 Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress. Methods: A prospective observational study was done at two tertiary care centers. The participants were divided into three distinct categories based on their body mass index BMI: The control group Group 1 consisted of 116 individuals with a BMI ranging from 18 to 25 kgm², while the overweight group Group 2, n  89 included those with a BMI between 25 and 30 kgm². The obese group Group 3, n  39 comprised individuals with a BMI of 30 kgm² or greater. This approach primarily utilizes the disulfidenative thiol ratio, disulfidetotal thiol ratio, and native thioltotal thiol ratio as key metrics. All patients demographics, waist circumference, hip circumference, height, weight, hemoglobin, hematocrit, white blood cell count, glucose, C-reactive protein, disulfide, native-thiol NT, total-thiol TT, lipid hydroperoxide radical LOOH, and absolute ischemia-modified-albumin ABSO levels were recorded on calculations and records were made for disulfide to native and total thiol ratios. Results: Thiol-disulfide equilibrium differed between the three groups. NT concentrations averaged 368.87 mmolL across all individuals and were significantly higher in the normal-weight cohort BMI 18-25 kgm2 at 380.60 mmolL, compared to overweight and obese populations p0.001. TT concentrations were higher in normal-weight individuals, with an average of 426.3654.48 mmolL, compared to 405.4152.14 and 391.0746.45 in overweight and obese individuals, respectively p0.001. Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

 Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress. Methods: A prospective observational study was done at two tertiary care centers. The participants were divided into three distinct categories based on their body mass index BMI: The control group Group 1 consisted of 116 individuals with a BMI ranging from 18 to 25 kgm², while the overweight group Group 2, n  89 included those with a BMI between 25 and 30 kgm². The obese group Group 3, n  39 comprised individuals with a BMI of 30 kgm² or greater. This approach primarily utilizes the disulfidenative thiol ratio, disulfidetotal thiol ratio, and native thioltotal thiol ratio as key metrics. All patients demographics, waist circumference, hip circumference, height, weight, hemoglobin, hematocrit, white blood cell count, glucose, C-reactive protein, disulfide, native-thiol NT, total-thiol TT, lipid hydroperoxide radical LOOH, and absolute ischemia-modified-albumin ABSO levels were recorded on calculations and records were made for disulfide to native and total thiol ratios. Results: Thiol-disulfide equilibrium differed between the three groups. NT concentrations averaged 368.87 mmolL across all individuals and were significantly higher in the normal-weight cohort BMI 18-25 kgm2 at 380.60 mmolL, compared to overweight and obese populations p0.001. TT concentrations were higher in normal-weight individuals, with an average of 426.3654.48 mmolL, compared to 405.4152.14 and 391.0746.45 in overweight and obese individuals, respectively p0.001. Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

 Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress. Methods: A prospective observational study was done at two tertiary care centers. The participants were divided into three distinct categories based on their body mass index BMI: The control group Group 1 consisted of 116 individuals with a BMI ranging from 18 to 25 kgm², while the overweight group Group 2, n  89 included those with a BMI between 25 and 30 kgm². The obese group Group 3, n  39 comprised individuals with a BMI of 30 kgm² or greater. This approach primarily utilizes the disulfidenative thiol ratio, disulfidetotal thiol ratio, and native thioltotal thiol ratio as key metrics. All patients demographics, waist circumference, hip circumference, height, weight, hemoglobin, hematocrit, white blood cell count, glucose, C-reactive protein, disulfide, native-thiol NT, total-thiol TT, lipid hydroperoxide radical LOOH, and absolute ischemia-modified-albumin ABSO levels were recorded on calculations and records were made for disulfide to native and total thiol ratios. Results: Thiol-disulfide equilibrium differed between the three groups. NT concentrations averaged 368.87 mmolL across all individuals and were significantly higher in the normal-weight cohort BMI 18-25 kgm2 at 380.60 mmolL, compared to overweight and obese populations p0.001. TT concentrations were higher in normal-weight individuals, with an average of 426.3654.48 mmolL, compared to 405.4152.14 and 391.0746.45 in overweight and obese individuals, respectively p0.001. Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

 Objectives: Thiol-disulfide measurements will assess obesity-related oxidative stress. Methods: A prospective observational study was done at two tertiary care centers. The participants were divided into three distinct categories based on their body mass index BMI: The control group Group 1 consisted of 116 individuals with a BMI ranging from 18 to 25 kgm², while the overweight group Group 2, n  89 included those with a BMI between 25 and 30 kgm². The obese group Group 3, n  39 comprised individuals with a BMI of 30 kgm² or greater. This approach primarily utilizes the disulfidenative thiol ratio, disulfidetotal thiol ratio, and native thioltotal thiol ratio as key metrics. All patients demographics, waist circumference, hip circumference, height, weight, hemoglobin, hematocrit, white blood cell count, glucose, C-reactive protein, disulfide, native-thiol NT, total-thiol TT, lipid hydroperoxide radical LOOH, and absolute ischemia-modified-albumin ABSO levels were recorded on calculations and records were made for disulfide to native and total thiol ratios. Results: Thiol-disulfide equilibrium differed between the three groups. NT concentrations averaged 368.87 mmolL across all individuals and were significantly higher in the normal-weight cohort BMI 18-25 kgm2 at 380.60 mmolL, compared to overweight and obese populations p0.001. TT concentrations were higher in normal-weight individuals, with an average of 426.3654.48 mmolL, compared to 405.4152.14 and 391.0746.45 in overweight and obese individuals, respectively p0.001. Conclusions: Reduced native and total thiol levels, along with altered disulfide concentrations in obese individuals, serve as indicators of oxidative stress.

Makale detayları

The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity

Yazarlar:

Soner Yeşilyurt | Osman Erinç | Türker Demirtakan | Almila Şenat | Esra Fırat Oğuz | Nihat Mujdat Hokenek | Özcan Erel

Yayıncı:

Sakarya University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları | Klinik Kimya

Dergi:

Sakarya Tıp Dergisi Vol.15 Issue 3, pp.218-226

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358008

pISSN:

2146-409X

thiol disulfide balance

inflammatory markers

oxidative stress

obesity

Sayı

Makale detayları

The Clinical Role of the Thiol-Disulfide Balance as an Oxidative Stress Indicator in Patients with Obesity

Yazarlar: Soner Yeşilyurt | Osman Erinç | Türker Demirtakan | Almila Şenat | Esra Fırat Oğuz | Nihat Mujdat Hokenek | Özcan Erel

Yayıncı: Sakarya University

Ana Başlıklar: Endokrinoloji | İç Hastalıkları | Klinik Kimya

Dergi: Sakarya Tıp Dergisi Vol.15 Issue 3, pp.218-226

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358008

pISSN: 2146-409X

thiol disulfide balance

inflammatory markers

oxidative stress

obesity

Sayı

Yazarlar:

Soner Yeşilyurt | Osman Erinç | Türker Demirtakan | Almila Şenat | Esra Fırat Oğuz | Nihat Mujdat Hokenek | Özcan Erel

Yayıncı:

Sakarya University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları | Klinik Kimya

Dergi:

Sakarya Tıp Dergisi Vol.15 Issue 3, pp.218-226

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358008

pISSN:

2146-409X