A New Approach For Dıagnosıs Of Leıomyoma And Leıomyosarcoma: A Stereologıcal Study

Önder ŞAHİN; Cemal GÜNDOĞDU; Bunyami ÜNAL; Huseyin ASLAN; Bunyamin ŞAHİN; Suleyman KAPLAN

Makale detayları

A New Approach For Dıagnosıs Of Leıomyoma And Leıomyosarcoma: A Stereologıcal Study

Yazarlar:

Önder ŞAHİN | Cemal GÜNDOĞDU | Bunyami ÜNAL | Huseyin ASLAN | Bunyamin ŞAHİN | Suleyman KAPLAN

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.119-123

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000509883

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483

Özet:

 

Leiomyoma is a common benign tumor of the genital system; diseases and other types of smooth muscle tumors in females is called leiomyosarcoma. The diagnosis of these tumors is based on differentiation of the degree of cellularity and cytological atypia, presence of necrosis and particularly the mitotic index. A treatment procedure is proposed regarding to the diagnosis of leiomyoma and leiomyosarcoma. There is no exact agreement on diagnosis of these tumors and the available methods are biased and dependent on the judgment of the observers. Our aim is to evaluate the leiomyoma and leiomyosarcoma type of tumors using design-based stereological methods. The number of cells showing mitosis within a reference volume was determined to diagnose the type of tumor as leiomyoma or leiomyosarcoma. Numerical density of mitotic figures was 8000-9000/mm3 for leiomyoma, 10.000-11.000/mm3 for leiomyoma with high mitotic activity, and 30.000-31.000/mm3 for leiomyosarcoma. The difference between leiomyoma and leiomyosarcoma was significant (p<0.001). These results show that the proposed method of providing the numerical density of mitosis for the diagnosis of leiomyosarcoma is unbiased, objective, and reliable. Moreover the method is more effective and easier to use than a morphometric method.

Makale detayları

A New Approach For Dıagnosıs Of Leıomyoma And Leıomyosarcoma: A Stereologıcal Study

Yazarlar: Önder ŞAHİN | Cemal GÜNDOĞDU | Bunyami ÜNAL | Huseyin ASLAN | Bunyamin ŞAHİN | Suleyman KAPLAN

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.119-123

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000509883

Sıklık: Üç Aylık

eISSN: 1309-5129

pISSN: 1309-4483

Sayı

Yazarlar:

Önder ŞAHİN | Cemal GÜNDOĞDU | Bunyami ÜNAL | Huseyin ASLAN | Bunyamin ŞAHİN | Suleyman KAPLAN

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2009 Vol.26 Issue 3, pp.119-123

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000509883

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483