Evaluation of Renal Effects of Dapagliflozin in Diabetic Rats with Subacute Exposure

Tugce Boran; Bahar Ulus Karaca; Ayça Karagöz Köroğlu; Feriha Ercan; Gül Özhan

Makale detayları

Evaluation of Renal Effects of Dapagliflozin in Diabetic Rats with Subacute Exposure

Yazarlar:

Tugce Boran | Bahar Ulus Karaca | Ayça Karagöz Köroğlu | Feriha Ercan | Gül Özhan

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 3, pp.232-242

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297948

pISSN:

2458-8806

Anahtar kelimeler:

Özet:

 ABSTRACT Dapagliflozin DAPA, a sodium glucose co-transporter 2 SGLT2 inhibitor, is used for the treatment of type 2 diabetes. Although several studies have demonstrated its protective effects on the kidney, the FDA warns about the risk of DAPA-induced nephrotoxicity. SGLT2 inhibitors may induce oxidative stress and inflammation in the kidney due to their mechanism of action. In the present study, it was aimed to clarify the molecular effects of DAPA on the kidney. Diabetes was induced by single injection of streptozotocin STZ 35 mgkg b.w. after the rats were fed with high-fat diet for two-weeks. Diabetic rats were administered with DAPA at 10 mgkg by oral gavage for 28 days. The oxidative stress, inflammation and apoptosis induction potentials of DAPA were evaluated. The morphological changes and apoptosis were investigated by histological examinations. The findings showed that DAPA treatment reduced oxidative parameters and slightly inhibited inflammatory mediator levels. According to the histological examinations, DAPA ameliorated the diabetes-induced changes and apoptosis. As a result, DAPA showed a protective effect on the kidney by alleviating oxidative stress and inhibiting inflammation and apoptosis. However, further studies are needed to determine the long-term effects of DAPA on the kidney in diabetic patients.

 ABSTRACT Dapagliflozin DAPA, a sodium glucose co-transporter 2 SGLT2 inhibitor, is used for the treatment of type 2 diabetes. Although several studies have demonstrated its protective effects on the kidney, the FDA warns about the risk of DAPA-induced nephrotoxicity. SGLT2 inhibitors may induce oxidative stress and inflammation in the kidney due to their mechanism of action. In the present study, it was aimed to clarify the molecular effects of DAPA on the kidney. Diabetes was induced by single injection of streptozotocin STZ 35 mgkg b.w. after the rats were fed with high-fat diet for two-weeks. Diabetic rats were administered with DAPA at 10 mgkg by oral gavage for 28 days. The oxidative stress, inflammation and apoptosis induction potentials of DAPA were evaluated. The morphological changes and apoptosis were investigated by histological examinations. The findings showed that DAPA treatment reduced oxidative parameters and slightly inhibited inflammatory mediator levels. According to the histological examinations, DAPA ameliorated the diabetes-induced changes and apoptosis. As a result, DAPA showed a protective effect on the kidney by alleviating oxidative stress and inhibiting inflammation and apoptosis. However, further studies are needed to determine the long-term effects of DAPA on the kidney in diabetic patients.

 ABSTRACT Dapagliflozin DAPA, a sodium glucose co-transporter 2 SGLT2 inhibitor, is used for the treatment of type 2 diabetes. Although several studies have demonstrated its protective effects on the kidney, the FDA warns about the risk of DAPA-induced nephrotoxicity. SGLT2 inhibitors may induce oxidative stress and inflammation in the kidney due to their mechanism of action. In the present study, it was aimed to clarify the molecular effects of DAPA on the kidney. Diabetes was induced by single injection of streptozotocin STZ 35 mgkg b.w. after the rats were fed with high-fat diet for two-weeks. Diabetic rats were administered with DAPA at 10 mgkg by oral gavage for 28 days. The oxidative stress, inflammation and apoptosis induction potentials of DAPA were evaluated. The morphological changes and apoptosis were investigated by histological examinations. The findings showed that DAPA treatment reduced oxidative parameters and slightly inhibited inflammatory mediator levels. According to the histological examinations, DAPA ameliorated the diabetes-induced changes and apoptosis. As a result, DAPA showed a protective effect on the kidney by alleviating oxidative stress and inhibiting inflammation and apoptosis. However, further studies are needed to determine the long-term effects of DAPA on the kidney in diabetic patients.

 ABSTRACT Dapagliflozin DAPA, a sodium glucose co-transporter 2 SGLT2 inhibitor, is used for the treatment of type 2 diabetes. Although several studies have demonstrated its protective effects on the kidney, the FDA warns about the risk of DAPA-induced nephrotoxicity. SGLT2 inhibitors may induce oxidative stress and inflammation in the kidney due to their mechanism of action. In the present study, it was aimed to clarify the molecular effects of DAPA on the kidney. Diabetes was induced by single injection of streptozotocin STZ 35 mgkg b.w. after the rats were fed with high-fat diet for two-weeks. Diabetic rats were administered with DAPA at 10 mgkg by oral gavage for 28 days. The oxidative stress, inflammation and apoptosis induction potentials of DAPA were evaluated. The morphological changes and apoptosis were investigated by histological examinations. The findings showed that DAPA treatment reduced oxidative parameters and slightly inhibited inflammatory mediator levels. According to the histological examinations, DAPA ameliorated the diabetes-induced changes and apoptosis. As a result, DAPA showed a protective effect on the kidney by alleviating oxidative stress and inhibiting inflammation and apoptosis. However, further studies are needed to determine the long-term effects of DAPA on the kidney in diabetic patients.

Makale detayları

Evaluation of Renal Effects of Dapagliflozin in Diabetic Rats with Subacute Exposure

Yazarlar:

Tugce Boran | Bahar Ulus Karaca | Ayça Karagöz Köroğlu | Feriha Ercan | Gül Özhan

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 3, pp.232-242

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297948

pISSN:

2458-8806

Dapagliflozin

SGLT2 inhibitors

Nephrotoxicity

Diabetes

renoprotective effectDapagliflozin

SGLT2 inhibitors

nephrotoxicity

diabetes

renoprotective effect

Sayı

Makale detayları

Yazarlar: Tugce Boran | Bahar Ulus Karaca | Ayça Karagöz Köroğlu | Feriha Ercan | Gül Özhan

Yayıncı: Hacettepe University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 3, pp.232-242

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001297948

pISSN: 2458-8806

Sayı

Yazarlar:

Tugce Boran | Bahar Ulus Karaca | Ayça Karagöz Köroğlu | Feriha Ercan | Gül Özhan

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 3, pp.232-242

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297948

pISSN:

2458-8806