THE COURSE OF BEHÇET’S DISEASE FOLLOWING COVID-19 DIAGNOSIS: A LARGE RETROSPECTIVE COHORT STUDY

Tuğba Atcı; Yasemin Erdem; Dilay Yerlioğlu Ak; Afet Akdağ Köse

Makale detayları

THE COURSE OF BEHÇET’S DISEASE FOLLOWING COVID-19 DIAGNOSIS: A LARGE RETROSPECTIVE COHORT STUDY

Yazarlar:

Tuğba Atcı | Yasemin Erdem | Dilay Yerlioğlu Ak | Afet Akdağ Köse

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 3, pp.202-208

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330650

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: Behçets disease BD is a chronic vasculitic disease with mucocutaneous and systemic involvements. This study aims to examine the effects of COVID-19 on the symptoms and course of BD. Material and Method: The BD patients who were followed up in our department with a history of COVID-19 were evaluated regarding the course of infection and the course of BD postCOVID diagnosis, assessed by Behçets Disease Activity Index BDAI. Result: Among 449 BD patients, 68 15.1 had contracted COVID-19. The mean age of the patients was 42.711.8 years of whom 63.2 n43 were female. While most n48, 70.6 had only mucocutaneous symptoms, others also had systemic symptoms n20, 29.4 during their BD course; 86.8 n59 had received colchicine only at the time of infection. Prior to infection, 85.3 n58 had been in remission BDAI score of 0, while 14.7 n10 already had active BD BDAI score between 1-3. Post-COVID-19 diagnosis, activation or exacerbation of activation was seen in 39.7 n27 of BD patients, as characterized by increased BDAI scores BDAI score between 1-4. No change was recorded in 60.3 n41 of the patients. Disease activation in the BD patients was mostly mucocutaneous n21, 30.9. Comparison of the BD patients BDAI scores pre- and post-COVID-19 diagnosis revealed the scores to be significantly elevated p0.001; z-4.691, demonstrating the possible effects of COVID-19 on BD severity. Conclusion: COVID-19 infection may lead to activation of BD symptoms, with new organs being involved in some patients, which should be confirmed by prospective large series.

 Objective: Behçets disease BD is a chronic vasculitic disease with mucocutaneous and systemic involvements. This study aims to examine the effects of COVID-19 on the symptoms and course of BD. Material and Method: The BD patients who were followed up in our department with a history of COVID-19 were evaluated regarding the course of infection and the course of BD postCOVID diagnosis, assessed by Behçets Disease Activity Index BDAI. Result: Among 449 BD patients, 68 15.1 had contracted COVID-19. The mean age of the patients was 42.711.8 years of whom 63.2 n43 were female. While most n48, 70.6 had only mucocutaneous symptoms, others also had systemic symptoms n20, 29.4 during their BD course; 86.8 n59 had received colchicine only at the time of infection. Prior to infection, 85.3 n58 had been in remission BDAI score of 0, while 14.7 n10 already had active BD BDAI score between 1-3. Post-COVID-19 diagnosis, activation or exacerbation of activation was seen in 39.7 n27 of BD patients, as characterized by increased BDAI scores BDAI score between 1-4. No change was recorded in 60.3 n41 of the patients. Disease activation in the BD patients was mostly mucocutaneous n21, 30.9. Comparison of the BD patients BDAI scores pre- and post-COVID-19 diagnosis revealed the scores to be significantly elevated p0.001; z-4.691, demonstrating the possible effects of COVID-19 on BD severity. Conclusion: COVID-19 infection may lead to activation of BD symptoms, with new organs being involved in some patients, which should be confirmed by prospective large series.

 Objective: Behçets disease BD is a chronic vasculitic disease with mucocutaneous and systemic involvements. This study aims to examine the effects of COVID-19 on the symptoms and course of BD. Material and Method: The BD patients who were followed up in our department with a history of COVID-19 were evaluated regarding the course of infection and the course of BD postCOVID diagnosis, assessed by Behçets Disease Activity Index BDAI. Result: Among 449 BD patients, 68 15.1 had contracted COVID-19. The mean age of the patients was 42.711.8 years of whom 63.2 n43 were female. While most n48, 70.6 had only mucocutaneous symptoms, others also had systemic symptoms n20, 29.4 during their BD course; 86.8 n59 had received colchicine only at the time of infection. Prior to infection, 85.3 n58 had been in remission BDAI score of 0, while 14.7 n10 already had active BD BDAI score between 1-3. Post-COVID-19 diagnosis, activation or exacerbation of activation was seen in 39.7 n27 of BD patients, as characterized by increased BDAI scores BDAI score between 1-4. No change was recorded in 60.3 n41 of the patients. Disease activation in the BD patients was mostly mucocutaneous n21, 30.9. Comparison of the BD patients BDAI scores pre- and post-COVID-19 diagnosis revealed the scores to be significantly elevated p0.001; z-4.691, demonstrating the possible effects of COVID-19 on BD severity. Conclusion: COVID-19 infection may lead to activation of BD symptoms, with new organs being involved in some patients, which should be confirmed by prospective large series.

 Amaç: Behçet hastalığı mukokutanöz ve sistemik bulgularla seyredebilen kronik vaskülitik bir hastalıktır. Bu çalışmada Covid-19 enfeksiyonunun Behçet hastalığı semptomları ve seyri üzerine etkisini incelemeyi amaçladık. Gereç ve Yöntem: Üçüncü basamak bir Dermatoloji merkezinde takip edilen Behçet hastaları Covid-19 enfeksiyonu açısından sorgulandı. Daha önce PCR ile kanıtlanmış Covid-19 geçiren hastalarda Behçet hastalığı seyri ve aktivasyonu Behçet Hastalığı Aktivite İndeksi BHAİ ile retrospektif olarak değerlendirildi. Bulgular: Bu çalışma sürecinde poliklinik kontrolüne başvuran 449 Behçet hastasının 68inin 15,1 Covid-19 enfeksiyonu geçirme öyküsü mevcuttu. Hastaların yaş ortalaması 42,711,8 yıl olup, 63,2si n43 kadındı. Behçet hastalarımızın çoğunda n48, 70,6 Behçet hastalığı sadece mukokutanöz tutulum ile seyrederken, bir kısmında n20, 29,4 çeşitli sistemik tutulumlar hastalık sürecinde gelişmişti. Bu hastaların büyük bir çoğunluğu n59, 86,8 enfeksiyon öncesinde sadece kolşisin tedavisi almaktaydı. Covid-19 enfeksiyonu öncesi BHAİ skorlama sistemine bakıldığında hastalarımızın 85,3ü n58 remisyondaydı BHAİ0, 14,7si n10 ise halihazırda aktivasyondaydı BHAİ-1-3. Covid-19 enfeksiyonunu takiben hastaların 39,7sinde n27 aktivasyon veya hastalık şiddetinde artış görüldü BHAİ-1-4. Behçet hastalarımızda enfeksiyonu takiben görülen hastalık aktivasyonu çoğunlukla mukokutanöz n21, 30,9 lezyonlar ile karakterizeydi. Hastaların 60,3ünde n41 ise hastalık seyrinde herhangi bir değişiklik kaydedilmedi. Behçet hastalarında Covid-19 enfeksiyonu öncesi ve enfeksiyon sonrası BHAİ skorları karşılaştırıldığında anlamlı düzeyde p0,001 ve z-4,691 Behçet hastalık şiddetinde artış tespit edildi. Sonuç: Covid-19 enfeksiyonu bazı hastalarda Behçet hastalığı semptomlarının aktivasyonuna, alevlenmesine ve hatta yeni organ tutulumuna yol açabilmektedir. Bu durum prospektif geniş serilerle doğrulanmalıdır.

Makale detayları

THE COURSE OF BEHÇET’S DISEASE FOLLOWING COVID-19 DIAGNOSIS: A LARGE RETROSPECTIVE COHORT STUDY

Yazarlar:

Tuğba Atcı | Yasemin Erdem | Dilay Yerlioğlu Ak | Afet Akdağ Köse

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 3, pp.202-208

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330650

pISSN:

1305-6441

Behcet’s disease

COVID-19

disease activityBehçet hastalığı

Covid-19

hastalık aktivitesi

Sayı

Makale detayları

THE COURSE OF BEHÇET’S DISEASE FOLLOWING COVID-19 DIAGNOSIS: A LARGE RETROSPECTIVE COHORT STUDY

Yazarlar: Tuğba Atcı | Yasemin Erdem | Dilay Yerlioğlu Ak | Afet Akdağ Köse

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 3, pp.202-208

Belge Tipi: Makale

Yayın Tarihi: 7/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330650

pISSN: 1305-6441

Behcet’s disease

COVID-19

disease activityBehçet hastalığı

Covid-19

hastalık aktivitesi

Sayı

Yazarlar:

Tuğba Atcı | Yasemin Erdem | Dilay Yerlioğlu Ak | Afet Akdağ Köse

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 3, pp.202-208

Belge Tipi:

Makale

Yayın Tarihi:

7/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330650

pISSN:

1305-6441