Endothelial Cell Specific Molecule-1 (Endocan) Levels in Dogs with Parvoviral Enteritis

Mehmet Mustafa Oflaz; Vehbi Güneş

Makale detayları

Endothelial Cell Specific Molecule-1 (Endocan) Levels in Dogs with Parvoviral Enteritis

Yazarlar:

Mehmet Mustafa Oflaz | Vehbi Güneş

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.176-183

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001332605

pISSN:

1304-7280

Anahtar kelimeler:

Özet:

 Endocan or Endothelial Cell Specific Molecule-1 ESM-1 has been proven to play a key role in the regula-tion of processes such as cell adhesion, inflammation and tumor development. In this study, we aimed to investigate the role of Endocan as a potential inflammatory biomarker in dogs with Parvoviral Enteritis PVE due to increased Endocan levels in the presence of proinflammatory and proangiogenic molecules. The study included 40 dogs 24 ma-les, 16 females, 6-20 weeks old, of different breeds, with diarrhea bloodybloodless, weakness and canine parvovirus CPV antigen positive dogs. The control group consisted of 20 healthy dogs 12 males, 8 females. Endocan, IL-6 and CRP levels in serum samples of all dogs were analyzed by sandwich ELISA method. Mean Endocan levels were signi-ficantly higher in dogs with PVE 68.07 ngL; 17.30-115.55 compared to the healthy group 11.92 ngL; 10.32-13.58 P0.001. Both mean CRP level 20.876.34 mgL and mean IL-6 levels 2.320.84 pgml in the patient group were statistically significantly P0.01 higher than the healthy group 2.240.66 mgL and 1.070.61 pgml. In addition, due to the positive correlations between Endocan and CRP levels and IL-6 values, Endocan was considered to be a syste-mic component of the inflammatory process. In conclusion, findings supporting that Endocan levels in dogs with parvo-viral enteritis is an important biomarker in patients were obtained.

 Endocan or Endothelial Cell Specific Molecule-1 ESM-1 has been proven to play a key role in the regula-tion of processes such as cell adhesion, inflammation and tumor development. In this study, we aimed to investigate the role of Endocan as a potential inflammatory biomarker in dogs with Parvoviral Enteritis PVE due to increased Endocan levels in the presence of proinflammatory and proangiogenic molecules. The study included 40 dogs 24 ma-les, 16 females, 6-20 weeks old, of different breeds, with diarrhea bloodybloodless, weakness and canine parvovirus CPV antigen positive dogs. The control group consisted of 20 healthy dogs 12 males, 8 females. Endocan, IL-6 and CRP levels in serum samples of all dogs were analyzed by sandwich ELISA method. Mean Endocan levels were signi-ficantly higher in dogs with PVE 68.07 ngL; 17.30-115.55 compared to the healthy group 11.92 ngL; 10.32-13.58 P0.001. Both mean CRP level 20.876.34 mgL and mean IL-6 levels 2.320.84 pgml in the patient group were statistically significantly P0.01 higher than the healthy group 2.240.66 mgL and 1.070.61 pgml. In addition, due to the positive correlations between Endocan and CRP levels and IL-6 values, Endocan was considered to be a syste-mic component of the inflammatory process. In conclusion, findings supporting that Endocan levels in dogs with parvo-viral enteritis is an important biomarker in patients were obtained.

 Endocan or Endothelial Cell Specific Molecule-1 ESM-1 has been proven to play a key role in the regula-tion of processes such as cell adhesion, inflammation and tumor development. In this study, we aimed to investigate the role of Endocan as a potential inflammatory biomarker in dogs with Parvoviral Enteritis PVE due to increased Endocan levels in the presence of proinflammatory and proangiogenic molecules. The study included 40 dogs 24 ma-les, 16 females, 6-20 weeks old, of different breeds, with diarrhea bloodybloodless, weakness and canine parvovirus CPV antigen positive dogs. The control group consisted of 20 healthy dogs 12 males, 8 females. Endocan, IL-6 and CRP levels in serum samples of all dogs were analyzed by sandwich ELISA method. Mean Endocan levels were signi-ficantly higher in dogs with PVE 68.07 ngL; 17.30-115.55 compared to the healthy group 11.92 ngL; 10.32-13.58 P0.001. Both mean CRP level 20.876.34 mgL and mean IL-6 levels 2.320.84 pgml in the patient group were statistically significantly P0.01 higher than the healthy group 2.240.66 mgL and 1.070.61 pgml. In addition, due to the positive correlations between Endocan and CRP levels and IL-6 values, Endocan was considered to be a syste-mic component of the inflammatory process. In conclusion, findings supporting that Endocan levels in dogs with parvo-viral enteritis is an important biomarker in patients were obtained.

 Endocan veya Endotelyal Hucre Spesifik Molekul-1 ESM-1, hucre adezyonu, inflamasyon ve tumör gelişimi gibi sureçlerin duzenlenmesinde anahtar bir rol oynadığı kanıtlanmıştır. Bu çalışmada proinflamatuar ve proanjiyojenik molekullerin varlığında Endocan duzeylerindeki artış nedeniyle Parvoviral Enteritisli PVE köpeklerde potansiyel yan-gısal biyobelirteç rolunun araştırılması amaçlandı. Çalışmaya 6-20 haftalık, farklı ırklarda, 40 adet 24 erkek, 16 dişi ishal kanlıkansız, halsizlik şikâyeti bulunan ve köpek parvovirus CPV antijen pozitif köpek dâhil edildi. Kontrol gru-bunu; 20 adet sağlıklı köpek 12 erkek, 8 dişi oluşturdu. Tum köpeklerin serum örneklerinde; Endocan, IL-6 ve CRP duzeyleri sandviç ELISA metodu ile analiz edildi. Ortalama Endocan duzeylerinin PVEli köpeklerde 68.07 ngL; 17.30-115.55 sağlıklı gruba göre 11.92 ngL; 10.32-13.58 istatistiksel açıdan P0.001 anlamlı duzeyde yuksek olduğu saptandı. Hasta grubundaki hem ortalama CRP duzeyi 20.876.34 mgL, hem de ortalama IL-6 duzeyleri 2.320.84 pgml, sağlıklılardan 2.240.66 mgL ve 1.070.61 pgml istatistiksel açıdan önemli oranda P0.01 yuksekti. Ayrıca Endocan ile CRP duzeyleri ve IL-6 değerleri arasındaki pozitif korelasyonlar nedeni ile Endocanın yangısal surecin sistemik bir bileşeni olduğu değerlendirildi. Sonuçta PVEli köpeklerde Endocan duzeylerinin hastalarda önemli bir bi-yobelirteç olduğunu destekleyen bulgular elde edildi.

Makale detayları

Endothelial Cell Specific Molecule-1 (Endocan) Levels in Dogs with Parvoviral Enteritis

Yazarlar:

Mehmet Mustafa Oflaz | Vehbi Güneş

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.176-183

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001332605

pISSN:

1304-7280

Biomarker

dog

endocan

parvoviral enteritisBiyobelirteç

endocan

köpek

parvoviral enteritis

Sayı

Makale detayları

Yazarlar: Mehmet Mustafa Oflaz | Vehbi Güneş

Yayıncı: Erciyes University

Ana Başlıklar: Veteriner Bilimleri (Diğer)

Dergi: Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.176-183

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001332605

pISSN: 1304-7280

Sayı

Yazarlar:

Mehmet Mustafa Oflaz | Vehbi Güneş

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Bilimleri (Diğer)

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.176-183

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001332605

pISSN:

1304-7280