Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Cemile DAYANGAN SAYAN; Müzeyyen Gülnur ÖZAKŞİT; Esma SARIKAYA

doi:https://doi.org/10.3906/sag-1205-85

Makale detayları

Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Yazarlar:

Cemile DAYANGAN SAYAN | Müzeyyen Gülnur ÖZAKŞİT | Esma SARIKAYA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.417-423

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000753732

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1205-85

Anahtar kelimeler:

Özet:

 

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis.  Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study.   Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not.  Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

 

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis.  Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study.   Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not.  Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

Makale detayları

Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Yazarlar:

Cemile DAYANGAN SAYAN | Müzeyyen Gülnur ÖZAKŞİT | Esma SARIKAYA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.417-423

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000753732

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1205-85

Key words: Endometriosis

interleukin-8

CA-125

neutrophil-to-lymphocyte ratio

Sayı

Makale detayları

Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Yazarlar: Cemile DAYANGAN SAYAN | Müzeyyen Gülnur ÖZAKŞİT | Esma SARIKAYA

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.417-423

Belge Tipi: Makale

Yayın Tarihi: 2/2013

Belge Dili: İngilizce

Document ID (Org No.): 2000753732

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1205-85

Key words: Endometriosis

interleukin-8

CA-125

neutrophil-to-lymphocyte ratio

Sayı

Yazarlar:

Cemile DAYANGAN SAYAN | Müzeyyen Gülnur ÖZAKŞİT | Esma SARIKAYA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.417-423

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000753732

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1205-85