Expression profiles of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyposis

Alper DİLCİ; Nuray VAROL; İlker KILIÇCIOĞLU; Ece KONAC; Utku AYDİL; Yusuf KIZIL; Süleyman Sabri USLU

Makale detayları

Expression profiles of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyposis

Yazarlar:

Alper DİLCİ | Nuray VAROL | İlker KILIÇCIOĞLU | Ece KONAC | Utku AYDİL | Yusuf KIZIL | Süleyman Sabri USLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1757-1764

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000750989

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Nasal polyposis is a chronic inflammatory disease affecting the paranasal sinuses and nasal mucosae. It is thought that genetic and molecular mechanisms in inflammatory and apoptotic pathways are the main factors in the etiopathogenesis of nasal polyposis. The aim of this study was to investigate the expression patterns of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyps.Materials and methods: The mRNA expression levels of CD11b, galectin-1, beclin-1, and caspase-3 protein and western blot analysis of caspase-3 protein were evaluated in inferior turbinate mucosae and nasal polyp tissues.Results: CD11b expression was markedly higher in nasal polyp tissues when compared to turbinate mucosae (5.5 times higher, P < 0.05). Expression of galectin-1 was not statistically higher in nasal polyp tissues when compared to the controls. Beclin-1 expression in nasal polyp tissues was lower than in controls (17 times lower, P < 0.05). Caspase-3 expression was significantly lower in nasal polyp tissues than in controls (5.5 times lower, P < 0.05).Conclusion: Inflammation, apoptosis, and hyperproliferation are the major cellular processes in nasal polyposis and these proteins may take part and play some important roles in formation of this disease and the targeting of new treatment protocols.

Makale detayları

Expression profiles of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyposis

Yazarlar: Alper DİLCİ | Nuray VAROL | İlker KILIÇCIOĞLU | Ece KONAC | Utku AYDİL | Yusuf KIZIL | Süleyman Sabri USLU

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1757-1764

Belge Tipi: Makale

Yayın Tarihi: 11/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000750989

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Alper DİLCİ | Nuray VAROL | İlker KILIÇCIOĞLU | Ece KONAC | Utku AYDİL | Yusuf KIZIL | Süleyman Sabri USLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1757-1764

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000750989

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144