The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

Murat YAĞMURCA; Muharrem UÇAR; Ersin FADILLIOĞLU

Makale detayları

The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

Yazarlar:

Murat YAĞMURCA | Muharrem UÇAR | Ersin FADILLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

12/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755572

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world, causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by Nω-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA.   Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME, and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution.   Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa.   Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA.

 

Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world, causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by Nω-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA.   Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME, and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution.   Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa.   Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA.

Makale detayları

The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

Yazarlar:

Murat YAĞMURCA | Muharrem UÇAR | Ersin FADILLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

12/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755572

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Nitric oxide

stomach injury

acetylsalicylic acid

microscopy

Sayı

Makale detayları

The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

Yazarlar: Murat YAĞMURCA | Muharrem UÇAR | Ersin FADILLIOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 1, pp.13-19

Belge Tipi: Makale

Yayın Tarihi: 12/2008

Belge Dili: Türkçe

Document ID (Org No.): 2000755572

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Nitric oxide

stomach injury

acetylsalicylic acid

microscopy

Sayı

Yazarlar:

Murat YAĞMURCA | Muharrem UÇAR | Ersin FADILLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

12/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755572

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144