The effect of albumin to alkaline phosphatase ratio on survival in patients with metastatic  bone sarcomas

Emel Mutlu; Oktay Bozkurt; Mevlüde İnanç; Metin Ozkan; Sedat Tarık Fırat; Ramazan Coşar; İrfan Buğday; Muhammet Cengiz; Ahmet Kürşad Dişli; Murat Eser

Makale detayları

The effect of albumin to alkaline phosphatase ratio on survival in patients with metastatic bone sarcomas

Yazarlar:

Emel Mutlu | Oktay Bozkurt | Mevlüde İnanç | Metin Ozkan | Sedat Tarık Fırat | Ramazan Coşar | İrfan Buğday | Muhammet Cengiz | Ahmet Kürşad Dişli | Murat Eser

Yayıncı:

Hitit University

Ana Başlıklar:

Klinik Onkoloji | Ortopedi

Dergi:

Hitit Medical Journal Vol.6 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312332

pISSN:

2687-4717

Anahtar kelimeler:

Özet:

 Objective: To investigate the effect of albumin to alkaline phosphatase ratio AALPR at survival in patients with metastatic bone sarcomas. Patients and Methods: 60 patients with metastatic bone sarcomas were included in the study. The relationship between AALPR before chemotherapy and overal survival OS and progression free survival PFS was evaluated with Cox regression multivariate analysis. Results: Of the patients in the study, 25 58.3 were osteosarcoma, 16 26.7 Ewings sarcoma, 5 8.3 chondrosarcoma and 4 6.7 giant cell bone tumor. AALPR was 0.039 obtained in ROC analysis. The median PFS and OS at AALPR  0.039 group was statistically significantly higher than the group with 0.039 p0.006, p0.003. AALPR 0.039 was found to be associated with poor OS and PFS OS, HR1.778, 95 CI, 1.211-1.912, p0.023 - PFS, HR4.782, 95 CI, 1.963-11,647, p0.001 . Conclusion: In our study, low AALPR value before chemotherapy was associated with poor OS and PFS in patients with metastatic bone sarcoma. Low AALPR has been associated with poor OS and PFS in many cancer types, but the association of AALPR with survival at bone sarcoma patients has not been evaluated previously. Our study is the first in the literature to investigate this issue. AALPR can be used as an inexpensive and simple marker to evaluate the prognosis of patients. However, studies with larger number of patients are needed to give more precise results.

 Objective: To investigate the effect of albumin to alkaline phosphatase ratio AALPR at survival in patients with metastatic bone sarcomas. Patients and Methods: 60 patients with metastatic bone sarcomas were included in the study. The relationship between AALPR before chemotherapy and overal survival OS and progression free survival PFS was evaluated with Cox regression multivariate analysis. Results: Of the patients in the study, 25 58.3 were osteosarcoma, 16 26.7 Ewings sarcoma, 5 8.3 chondrosarcoma and 4 6.7 giant cell bone tumor. AALPR was 0.039 obtained in ROC analysis. The median PFS and OS at AALPR  0.039 group was statistically significantly higher than the group with 0.039 p0.006, p0.003. AALPR 0.039 was found to be associated with poor OS and PFS OS, HR1.778, 95 CI, 1.211-1.912, p0.023 - PFS, HR4.782, 95 CI, 1.963-11,647, p0.001 . Conclusion: In our study, low AALPR value before chemotherapy was associated with poor OS and PFS in patients with metastatic bone sarcoma. Low AALPR has been associated with poor OS and PFS in many cancer types, but the association of AALPR with survival at bone sarcoma patients has not been evaluated previously. Our study is the first in the literature to investigate this issue. AALPR can be used as an inexpensive and simple marker to evaluate the prognosis of patients. However, studies with larger number of patients are needed to give more precise results.

 Objective: To investigate the effect of albumin to alkaline phosphatase ratio AALPR at survival in patients with metastatic bone sarcomas. Patients and Methods: 60 patients with metastatic bone sarcomas were included in the study. The relationship between AALPR before chemotherapy and overal survival OS and progression free survival PFS was evaluated with Cox regression multivariate analysis. Results: Of the patients in the study, 25 58.3 were osteosarcoma, 16 26.7 Ewings sarcoma, 5 8.3 chondrosarcoma and 4 6.7 giant cell bone tumor. AALPR was 0.039 obtained in ROC analysis. The median PFS and OS at AALPR  0.039 group was statistically significantly higher than the group with 0.039 p0.006, p0.003. AALPR 0.039 was found to be associated with poor OS and PFS OS, HR1.778, 95 CI, 1.211-1.912, p0.023 - PFS, HR4.782, 95 CI, 1.963-11,647, p0.001 . Conclusion: In our study, low AALPR value before chemotherapy was associated with poor OS and PFS in patients with metastatic bone sarcoma. Low AALPR has been associated with poor OS and PFS in many cancer types, but the association of AALPR with survival at bone sarcoma patients has not been evaluated previously. Our study is the first in the literature to investigate this issue. AALPR can be used as an inexpensive and simple marker to evaluate the prognosis of patients. However, studies with larger number of patients are needed to give more precise results.

 Amaç: Metastatik kemik sarkomu hastalarında albümin-alkalen fosfataz oranının AALPO sağ kalıma etkisini araştırmak. Hasta ve Yöntem: Çalışmaya metastatik evrede olan 60 kemik sarkomu hastası dahil edildi. Kemoterapi öncesi bakılan AALPO ile genel sağkalım GS ve progresyonsuz sağkalım PS arasındaki ilişki Cox regresyonu multivariate analizi ile değerlendirildi. Bulgular: Çalışmaya alınan hastaların 25 58.3i osteosarkom, 16 26.7si Ewing sarkomu, 58.3ü kondrosarkom ve 4 6.7ü dev hücreli kemik tümörüydü. ROC analizi ile elde edilen AALPO değeri 0.039 olarak bulundu. AALPO  0,039 grubundaki medyan PS ve GS, 0,039 olan gruba göre istatistiksel olarak anlamlı derecede yüksekti p0.006, p0.003. AALPO 0.039 HR1.778, 95 Cl, 1.211-1.912, p0.023 olması düşük genel GS ile ilişkili ve HR4.782, 95 Cl, 1.963-11.647, p0.001 olması düşük PS ile ilişkili bulundu. Sonuç: Çalışmamızda metastatik kemik sarkomlu hastalarda kemoterapi öncesi düşük AALPO değeri, kötü GS ve PS ile ilişkili bulunmuştur. Daha önce birçok kanser türünde düşük AALPO kötü GS ve PS ile ilişkili bulunmuştur ancak daha önce kemik kanseri hastalarında AALPOnun sağ kalım ile ilişkisi değerlendirilmemiştir. Çalışmamız literatürde bu konuyu araştıran ilk çalışmadır. AALPO, hastaların prognozunu değerlendirmede ucuz ve basit bir belirteç olarak kullanılabilir. Ancak daha kesin sonuçlar söylemek için daha fazla hasta sayısı ile yapılacak çalışmalara ihtiyaç vardır.

Makale detayları

The effect of albumin to alkaline phosphatase ratio on survival in patients with metastatic bone sarcomas

Yazarlar:

Emel Mutlu | Oktay Bozkurt | Mevlüde İnanç | Metin Ozkan | Sedat Tarık Fırat | Ramazan Coşar | İrfan Buğday | Muhammet Cengiz | Ahmet Kürşad Dişli | Murat Eser

Yayıncı:

Hitit University

Ana Başlıklar:

Klinik Onkoloji | Ortopedi

Dergi:

Hitit Medical Journal Vol.6 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312332

pISSN:

2687-4717

Bone cancer

osteosarcoma

albumin to alkaline phosphatase ratio

neutrophil to lymphocyte ratiokemik kanseri

osteosarkom

nötrofil lenfosit oranı

albumin alkalen fosfataz oranı

Sayı

Makale detayları

Yazarlar: Emel Mutlu | Oktay Bozkurt | Mevlüde İnanç | Metin Ozkan | Sedat Tarık Fırat | Ramazan Coşar | İrfan Buğday | Muhammet Cengiz | Ahmet Kürşad Dişli | Murat Eser

Yayıncı: Hitit University

Ana Başlıklar: Klinik Onkoloji | Ortopedi

Dergi: Hitit Medical Journal Vol.6 Issue 1, pp.71-78

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312332

pISSN: 2687-4717

Sayı

Yazarlar:

Emel Mutlu | Oktay Bozkurt | Mevlüde İnanç | Metin Ozkan | Sedat Tarık Fırat | Ramazan Coşar | İrfan Buğday | Muhammet Cengiz | Ahmet Kürşad Dişli | Murat Eser

Yayıncı:

Hitit University

Ana Başlıklar:

Klinik Onkoloji | Ortopedi

Dergi:

Hitit Medical Journal Vol.6 Issue 1, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312332

pISSN:

2687-4717