Effects of Type 1 diabetes mellitus disease on iron metabolism and hepcidin level abstract

Bekir Ay; Can Acıpayam; Nurten Seringeç Akkeçeci; Fatih Temiz; Fatma İnanç Tolun

Makale detayları

Effects of Type 1 diabetes mellitus disease on iron metabolism and hepcidin level abstract

Yazarlar:

Bekir Ay | Can Acıpayam | Nurten Seringeç Akkeçeci | Fatih Temiz | Fatma İnanç Tolun

Yayıncı:

Cukurova University

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Endokrinolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.654-660

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357838

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study was to reveal the relationship between iron metabolism, hepcidin, and hemoglobin A1c HbA1c in type 1 diabetes mellitus T1DM patients with better and poor metabolic control. Materials and Methods: The study included 30 T1DM patients with poor metabolic control HbA1c value 7.5, 30 T1DM patients with better metabolic control HbA1c value 7.5, and 30 healthy controls who were of similar age and gender. Routine, hemogram, biochemical tests, iron, transferrin, and ferritin levels were evaluated. Results: The hepcidin level of the poor metabolic patient group 519.52114.58 was significantly higher than the control group 431.94124.05. The ferritin level of the poor metabolic patient group 52.1036.53 was significantly higher than that of the better metabolic patient group 35.1336.18 and the control group 28.6318.08. Positive relationships were found between HbA1c and hepcidin and ferritin. In receiver operating characteristic ROC analysis, hepcidin was at the threshold value of 445.20 and had 61.7 sensitivity and 56.0 specificity in diagnosing T1DM. Conclusion: Hepcidin and ferritin levels have been shown to increase in T1DM patients and both show a positive correlation with HbA1c. Hepcidin may be a promising marker contributing to the follow-up and diagnosis of T1DM.

 Purpose: The aim of this study was to reveal the relationship between iron metabolism, hepcidin, and hemoglobin A1c HbA1c in type 1 diabetes mellitus T1DM patients with better and poor metabolic control. Materials and Methods: The study included 30 T1DM patients with poor metabolic control HbA1c value 7.5, 30 T1DM patients with better metabolic control HbA1c value 7.5, and 30 healthy controls who were of similar age and gender. Routine, hemogram, biochemical tests, iron, transferrin, and ferritin levels were evaluated. Results: The hepcidin level of the poor metabolic patient group 519.52114.58 was significantly higher than the control group 431.94124.05. The ferritin level of the poor metabolic patient group 52.1036.53 was significantly higher than that of the better metabolic patient group 35.1336.18 and the control group 28.6318.08. Positive relationships were found between HbA1c and hepcidin and ferritin. In receiver operating characteristic ROC analysis, hepcidin was at the threshold value of 445.20 and had 61.7 sensitivity and 56.0 specificity in diagnosing T1DM. Conclusion: Hepcidin and ferritin levels have been shown to increase in T1DM patients and both show a positive correlation with HbA1c. Hepcidin may be a promising marker contributing to the follow-up and diagnosis of T1DM.

 Purpose: The aim of this study was to reveal the relationship between iron metabolism, hepcidin, and hemoglobin A1c HbA1c in type 1 diabetes mellitus T1DM patients with better and poor metabolic control. Materials and Methods: The study included 30 T1DM patients with poor metabolic control HbA1c value 7.5, 30 T1DM patients with better metabolic control HbA1c value 7.5, and 30 healthy controls who were of similar age and gender. Routine, hemogram, biochemical tests, iron, transferrin, and ferritin levels were evaluated. Results: The hepcidin level of the poor metabolic patient group 519.52114.58 was significantly higher than the control group 431.94124.05. The ferritin level of the poor metabolic patient group 52.1036.53 was significantly higher than that of the better metabolic patient group 35.1336.18 and the control group 28.6318.08. Positive relationships were found between HbA1c and hepcidin and ferritin. In receiver operating characteristic ROC analysis, hepcidin was at the threshold value of 445.20 and had 61.7 sensitivity and 56.0 specificity in diagnosing T1DM. Conclusion: Hepcidin and ferritin levels have been shown to increase in T1DM patients and both show a positive correlation with HbA1c. Hepcidin may be a promising marker contributing to the follow-up and diagnosis of T1DM.

 Amaç: Bu çalışmanın amacı daha iyi ve kötü metabolik kontrole sahip tip 1 diabetes mellitus T1DM hastalarında demir metabolizması, hepsidin ve hemoglobin A1c HbA1c arasındaki ilişkiyi ortaya koymaktır. Gereç ve Yöntem: Çalışmaya kötü metabolik kontrole sahip 30 T1DM hastası HbA1c değeri 7,5, daha iyi metabolik kontrole sahip 30 T1DM hastası HbA1c değeri 7,5 ve benzer yaş ve cinsiyete sahip 30 sağlıklı kontrol dahil edildi. Rutin, hemogram, biyokimyasal testler, demir, transferin ve ferritin düzeyleri değerlendirildi. Bulgular: Kötü metabolik hasta grubunun hepsidin seviyesi 519,52114,58 kontrol grubundan 431,94124,05 anlamlı olarak yüksekti. Kötü metabolik hasta grubunun ferritin seviyesi 52,1036,53 daha iyi metabolik hasta grubundan 35,1336,18 ve kontrol grubundan anlamlı olarak yüksekti 28,6318,08. HbA1c ile hepsidin ve ferritin arasında pozitif ilişkiler bulundu. Alıcı çalışma karakteristiği ROC analizinde, hepsidin 445,20 eşik değerindeydi ve T1DMyi teşhis etmede 61,7 duyarlılık ve 56,0 özgüllüğe sahipti. Sonuç: Hepsidin ve ferritin düzeylerinin T1DM hastalarında arttığı ve her ikisinin de HbA1c ile pozitif korelasyon gösterdiği gösterilmiştir. Hepsidin T1DM hastalığının takibine ve teşhisine katkıda bulunan umut verici bir belirteç olabilir.

Makale detayları

Effects of Type 1 diabetes mellitus disease on iron metabolism and hepcidin level abstract

Yazarlar:

Bekir Ay | Can Acıpayam | Nurten Seringeç Akkeçeci | Fatih Temiz | Fatma İnanç Tolun

Yayıncı:

Cukurova University

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Endokrinolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.654-660

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357838

pISSN:

2602-3032

Type 1 diabetes mellitus

hepcidin

iron metabolismAnahtar kelimeler: Tip 1 diabetes mellitus

hepsidin

demir metabolizması

Sayı

Makale detayları

Effects of Type 1 diabetes mellitus disease on iron metabolism and hepcidin level abstract

Yazarlar: Bekir Ay | Can Acıpayam | Nurten Seringeç Akkeçeci | Fatih Temiz | Fatma İnanç Tolun

Yayıncı: Cukurova University

Ana Başlıklar: Bebek ve Çocuk Sağlığı | Çocuk Endokrinolojisi

Dergi: Cukurova Medical Journal Vol.50 Issue 3, pp.654-660

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357838

pISSN: 2602-3032

Type 1 diabetes mellitus

hepcidin

iron metabolismAnahtar kelimeler: Tip 1 diabetes mellitus

hepsidin

demir metabolizması

Sayı

Yazarlar:

Bekir Ay | Can Acıpayam | Nurten Seringeç Akkeçeci | Fatih Temiz | Fatma İnanç Tolun

Yayıncı:

Cukurova University

Ana Başlıklar:

Bebek ve Çocuk Sağlığı | Çocuk Endokrinolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.654-660

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357838

pISSN:

2602-3032