The joint modeling approach with a simulation study for evaluating the association between the trajectory of serum albumin levels and mortality in peritoneal dialysis patients

Merve BAŞOL GÖKSÜLÜK; Dinçer GÖKSÜLÜK; Murat SİPAHİOĞLU; A. Ergun KARAAĞAOĞLU

doi:https://doi.org/10.15672/hujms.884326

Makale detayları

The joint modeling approach with a simulation study for evaluating the association between the trajectory of serum albumin levels and mortality in peritoneal dialysis patients

Yazarlar:

Merve BAŞOL GÖKSÜLÜK | Dinçer GÖKSÜLÜK | Murat SİPAHİOĞLU | A. Ergun KARAAĞAOĞLU

Yayıncı:

Hacettepe University

Ana Başlıklar:

Analiz

Dergi:

Hacettepe Journal of Mathematics and Statistics 2022 Vol.51 Issue 3, pp.900-913

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000450261

Sıklık:

İki Aylık

eISSN:

2651-477X

pISSN:

2651-477X

DOI:

https://doi.org/10.15672/hujms.884326

Özet:

 

We aimed to study the association between mortality and trajectory of serum albumin levels (g/dL) in peritoneal dialysis patients via a joint modeling approach. Joint modeling is a statistical method used to evaluate the relationship between longitudinal and time-to-event processes by fitting both sub-models simultaneously. A comprehensive simulation study was conducted to evaluate model performances and generalize the findings to more general scenarios. Model performances and prediction accuracies were evaluated using the time-dependent ROC area under the curve (AUC) and Brier score (BS). According to the real-life dataset results, the trajectory of serum albumin levels was inversely associated with mortality increasing the risk of death 2.21 times (p=0.003). The simulation results showed that the model performances increased with sample size. However, the model complexity had increased as more repeated measurements were taken from patients and resulted in lower prediction accuracy unless the sample size was increased. In conclusion, using the trajectory of risk predictors rather than baseline (or averaged) values provided better predictive accuracy and prevented biased results. Finally, the study design (e.g., number of samples and repeated measurements) should be carefully defined since it played an important role in model performances.

Makale detayları

The joint modeling approach with a simulation study for evaluating the association between the trajectory of serum albumin levels and mortality in peritoneal dialysis patients

Yazarlar: Merve BAŞOL GÖKSÜLÜK | Dinçer GÖKSÜLÜK | Murat SİPAHİOĞLU | A. Ergun KARAAĞAOĞLU

Yayıncı: Hacettepe University

Ana Başlıklar: Analiz

Dergi: Hacettepe Journal of Mathematics and Statistics 2022 Vol.51 Issue 3, pp.900-913

Belge Tipi: Makale

Yayın Tarihi: 5/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000450261

Sıklık: İki Aylık

eISSN: 2651-477X

pISSN: 2651-477X

DOI: https://doi.org/10.15672/hujms.884326

Sayı

Yazarlar:

Merve BAŞOL GÖKSÜLÜK | Dinçer GÖKSÜLÜK | Murat SİPAHİOĞLU | A. Ergun KARAAĞAOĞLU

Yayıncı:

Hacettepe University

Ana Başlıklar:

Analiz

Dergi:

Hacettepe Journal of Mathematics and Statistics 2022 Vol.51 Issue 3, pp.900-913

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000450261

Sıklık:

İki Aylık

eISSN:

2651-477X

pISSN:

2651-477X

DOI:

https://doi.org/10.15672/hujms.884326