Histopathological alterations kidney in adult male rats that prenatally exposed to diclofenac sodium: A histopathological study

Habib KHOSHVAGHTI; Kıymet Kübra YURT; Berrin Zuhal ALTUNKAYNAK; Aysın Pınar TÜRKMEN; Ebru AYRANCI; İşınsu AYDIN; Elfide Gizem KIVRAK; Mehmet Emin ÖNGER

Makale detayları

Histopathological alterations kidney in adult male rats that prenatally exposed to diclofenac sodium: A histopathological study

Yazarlar:

Habib KHOSHVAGHTI | Kıymet Kübra YURT | Berrin Zuhal ALTUNKAYNAK | Aysın Pınar TÜRKMEN | Ebru AYRANCI | İşınsu AYDIN | Elfide Gizem KIVRAK | Mehmet Emin ÖNGER

Yayıncı:

Ondokuz Mayıs University

Dergi:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

9/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000508533

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483

Özet:

 


 

In this study, we investigated the morphometric and histological alterations of the kidney in adult male rats that they were exposed to diclofenac sodium (DS) during pregnancy. For this purpose, pregnant rats were divided into two groups: the control and drug-treated groups. DS (Voltaren 75 mg/3 ml, Novartis, Turkey) was intraperitoneally injected to rats of the treated group beginning from the 5th day after mating through the 15th day of pregnancy. No injection was given to the rats in the control group. After spontaneous delivery, male offspring were obtained. Twelve weeks after from birth, kidney samples were removed from all animals. Following dissection and routine histological preparation, histopathological study was carried out. Our results indicate that DS application leads to pathological alterations in the kidney. Light microscopic investigation showed a dilatation in blood vessels and Bowman’s space, degeneration in nephrons, including glomerulosclerosis and tubular defects, and an increase in the connective tissue in the kidneys of the DS treated group. We suggested that diclofenac sodium usage may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney. Finally, in light of our findings, we may suggest that DS may lead to adverse effects in rats that are prenatally subjected to this drug.

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Makale detayları

Histopathological alterations kidney in adult male rats that prenatally exposed to diclofenac sodium: A histopathological study

Yazarlar: Habib KHOSHVAGHTI | Kıymet Kübra YURT | Berrin Zuhal ALTUNKAYNAK | Aysın Pınar TÜRKMEN | Ebru AYRANCI | İşınsu AYDIN | Elfide Gizem KIVRAK | Mehmet Emin ÖNGER

Yayıncı: Ondokuz Mayıs University

Dergi: Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi: Makale

Yayın Tarihi: 9/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000508533

Sıklık: Üç Aylık

eISSN: 1309-5129

pISSN: 1309-4483

Sayı

Yazarlar:

Habib KHOSHVAGHTI | Kıymet Kübra YURT | Berrin Zuhal ALTUNKAYNAK | Aysın Pınar TÜRKMEN | Ebru AYRANCI | İşınsu AYDIN | Elfide Gizem KIVRAK | Mehmet Emin ÖNGER

Yayıncı:

Ondokuz Mayıs University

Dergi:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

9/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000508533

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483