Studies on the Methylation of 5-Nitro-benzimidazoles

Mashooda HASAN; Farzana SHAHEEN and Uzma YUNUS

Makale detayları

Studies on the Methylation of 5-Nitro-benzimidazoles

Yazarlar:

Mashooda HASAN | Farzana SHAHEEN and Uzma YUNUS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2000 Vol.24 Issue 1, pp.73-80

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000730338

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Methylation of 2H, 5-nitro- (1) and 2-ethyl, 5-nitro- (2)  benzimidazoles separately with methyl iodide in acetone in the  presence of potassium carbonate yielded 2H, 5/6-nitro-(3A and 3B) and  2-ethyl, 5/6-nitro- (4A and 4B) methylbenzimidazoles respectively.   Methylation of 1 and 2 in dimethylformamide in place of acetone  yielded not only 3A, 3B and 4A, 4B respectively, but in addition  1,3-dimethyl-5-nitro-benzimidazol-2-one (5) was also obtained in each  case.  The structure of the synthesized compounds was determined with  the help of mass and 1H NMR spectroscopic analysis.

 

Methylation of 2H, 5-nitro- (1) and 2-ethyl, 5-nitro- (2)  benzimidazoles separately with methyl iodide in acetone in the  presence of potassium carbonate yielded 2H, 5/6-nitro-(3A and 3B) and  2-ethyl, 5/6-nitro- (4A and 4B) methylbenzimidazoles respectively.   Methylation of 1 and 2 in dimethylformamide in place of acetone  yielded not only 3A, 3B and 4A, 4B respectively, but in addition  1,3-dimethyl-5-nitro-benzimidazol-2-one (5) was also obtained in each  case.  The structure of the synthesized compounds was determined with  the help of mass and 1H NMR spectroscopic analysis.

Makale detayları

Studies on the Methylation of 5-Nitro-benzimidazoles

Yazarlar: Mashooda HASAN | Farzana SHAHEEN and Uzma YUNUS

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2000 Vol.24 Issue 1, pp.73-80

Belge Tipi: Makale

Yayın Tarihi: 12/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000730338

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mashooda HASAN | Farzana SHAHEEN and Uzma YUNUS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2000 Vol.24 Issue 1, pp.73-80

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000730338

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527