Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Özhan PAZARCI; Halef Okan DOĞAN; Seyran KILINÇ; İsmet Yalkin ÇAMURCU

Makale detayları

Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Yazarlar:

Özhan PAZARCI | Halef Okan DOĞAN | Seyran KILINÇ | İsmet Yalkin ÇAMURCU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 6, pp.1774-1778

Belge Tipi:

Makale

Yayın Tarihi:

11/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749809

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing.  Materials  and  methods:  A  total  of  34  patients  (10  females,  24  males)  with  bone  fractures  and  32  controls  (10  females,  22  males)  participated in this study. After collecting serum venous blood samples, the quantitative sandwich ELISA technique was used for the determination of serum mTOR and SESN 1 levels.Results: The mean serum mTOR level was significantly higher in the fracture group compared to the control group (P = 0.001). However, SESN 1 levels did not significantly differ between groups (P = 0.913).Conclusion: We found that serum mTOR levels increased on the first day after fracture compared to the control group. However, we obtained no significant difference between groups in terms of SESN 1 levels. This study may guide further clinical studies investigating the potential role of mTOR signaling in the bone healing process.

Makale detayları

Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Yazarlar: Özhan PAZARCI | Halef Okan DOĞAN | Seyran KILINÇ | İsmet Yalkin ÇAMURCU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 6, pp.1774-1778

Belge Tipi: Makale

Yayın Tarihi: 11/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749809

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Özhan PAZARCI | Halef Okan DOĞAN | Seyran KILINÇ | İsmet Yalkin ÇAMURCU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 6, pp.1774-1778

Belge Tipi:

Makale

Yayın Tarihi:

11/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749809

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144