Systemic Responses to Burn Injury

Barış ÇAKIR; Berrak Ç. YEĞEN

Makale detayları

Systemic Responses to Burn Injury

Yazarlar:

Barış ÇAKIR | Berrak Ç. YEĞEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2004 Vol.34 Issue 4, pp.215-226

Belge Tipi:

Makale

Yayın Tarihi:

3/2004

Belge Dili:

Türkçe

Document ID (Org No.):

2000756545

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The major causes of death in burn patients include multiple organ failure and infection. It is important for the clinician to understand the pathophysiology of burn injury and the effects it will have on the pharmacokinetics of a drug. The local and systemic inflammatory response to thermal injury is extremely complex, resulting in both local burn tissue damage and deleterious systemic effects on all other organ systems distant from the burn area itself. Thermal injury initiates systemic inflammatory reactions producing burn toxins and oxygen radicals and finally leads to peroxidation. The relationship between the amount of products of oxidative metabolism and natural scavengers of free radicals determines the outcome of local and distant tissue damage and further organ failure in burn injury. The injured tissue initiates an inflammation-induced hyperdynamic, hypermetabolic state that can lead to severe progressive distant organ failure. Despite recent advances, multiple organ failure (e.g., cardiac instability, respiratory or renal failure) and immune dysfunction remain major causes of burn morbidity and mortality. Further experimental and clinical studies will hopefully lead to a more complete understanding of these pathological processes. From that point it should be then possible to develop improved treatments for burn patients.

 

The major causes of death in burn patients include multiple organ failure and infection. It is important for the clinician to understand the pathophysiology of burn injury and the effects it will have on the pharmacokinetics of a drug. The local and systemic inflammatory response to thermal injury is extremely complex, resulting in both local burn tissue damage and deleterious systemic effects on all other organ systems distant from the burn area itself. Thermal injury initiates systemic inflammatory reactions producing burn toxins and oxygen radicals and finally leads to peroxidation. The relationship between the amount of products of oxidative metabolism and natural scavengers of free radicals determines the outcome of local and distant tissue damage and further organ failure in burn injury. The injured tissue initiates an inflammation-induced hyperdynamic, hypermetabolic state that can lead to severe progressive distant organ failure. Despite recent advances, multiple organ failure (e.g., cardiac instability, respiratory or renal failure) and immune dysfunction remain major causes of burn morbidity and mortality. Further experimental and clinical studies will hopefully lead to a more complete understanding of these pathological processes. From that point it should be then possible to develop improved treatments for burn patients.

Makale detayları

Systemic Responses to Burn Injury

Yazarlar:

Barış ÇAKIR | Berrak Ç. YEĞEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2004 Vol.34 Issue 4, pp.215-226

Belge Tipi:

Makale

Yayın Tarihi:

3/2004

Belge Dili:

Türkçe

Document ID (Org No.):

2000756545

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Thermal injury

multiple organ failure

oxygen radicals

proinflammatory cytokines

Sayı

Makale detayları

Systemic Responses to Burn Injury

Yazarlar: Barış ÇAKIR | Berrak Ç. YEĞEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2004 Vol.34 Issue 4, pp.215-226

Belge Tipi: Makale

Yayın Tarihi: 3/2004

Belge Dili: Türkçe

Document ID (Org No.): 2000756545

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Thermal injury

multiple organ failure

oxygen radicals

proinflammatory cytokines

Sayı

Yazarlar:

Barış ÇAKIR | Berrak Ç. YEĞEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2004 Vol.34 Issue 4, pp.215-226

Belge Tipi:

Makale

Yayın Tarihi:

3/2004

Belge Dili:

Türkçe

Document ID (Org No.):

2000756545

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144