Early oxidative status in adult patients with isolated traumatic brain injury

Özgür SÖĞÜT; Halil KAYA; Mehmet Tahir GÖKDEMİR; Leyla SOLDUK

Makale detayları

Early oxidative status in adult patients with isolated traumatic brain injury

Yazarlar:

Özgür SÖĞÜT | Halil KAYA | Mehmet Tahir GÖKDEMİR | Leyla SOLDUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.1010-1019

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753942

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate oxidative and antioxidative status, as well as the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), reflecting injury severity and neurological outcome during the early posttraumatic period in patients with isolated traumatic brain injury (TBI).  Materials and methods: Fifty-one adult patients with TBI and 45 eligible healthy volunteers as control subjects were enrolled. Plasma total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) were calculated as biomarkers of early oxidative changes in serum using a novel automated method.  Results: TOS levels and OSI values were significantly higher in nonsurvivors compared with those in survivors. However, there was no significant difference in TAS levels between survivors and nonsurvivors. GCS and RTS showed negative correlations with TOS levels, but neither was significantly related to OSI levels. Furthermore, GCS scores were negatively correlated with TAS levels, whereas RTS scores were not significantly related to TAS levels.  Conclusion: Patients with isolated TBI are exposed to potent oxidative stress. TOS, as an early oxidative stress biomarker, might reflect the severity of cerebral insult in those patients.

 

To investigate oxidative and antioxidative status, as well as the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), reflecting injury severity and neurological outcome during the early posttraumatic period in patients with isolated traumatic brain injury (TBI).  Materials and methods: Fifty-one adult patients with TBI and 45 eligible healthy volunteers as control subjects were enrolled. Plasma total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) were calculated as biomarkers of early oxidative changes in serum using a novel automated method.  Results: TOS levels and OSI values were significantly higher in nonsurvivors compared with those in survivors. However, there was no significant difference in TAS levels between survivors and nonsurvivors. GCS and RTS showed negative correlations with TOS levels, but neither was significantly related to OSI levels. Furthermore, GCS scores were negatively correlated with TAS levels, whereas RTS scores were not significantly related to TAS levels.  Conclusion: Patients with isolated TBI are exposed to potent oxidative stress. TOS, as an early oxidative stress biomarker, might reflect the severity of cerebral insult in those patients.

Makale detayları

Early oxidative status in adult patients with isolated traumatic brain injury

Yazarlar:

Özgür SÖĞÜT | Halil KAYA | Mehmet Tahir GÖKDEMİR | Leyla SOLDUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.1010-1019

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753942

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Head injury

clinical outcome

oxidative stress index

total oxidant status

total antioxidant status

Sayı

Makale detayları

Early oxidative status in adult patients with isolated traumatic brain injury

Yazarlar: Özgür SÖĞÜT | Halil KAYA | Mehmet Tahir GÖKDEMİR | Leyla SOLDUK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.1010-1019

Belge Tipi: Makale

Yayın Tarihi: 5/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000753942

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Head injury

clinical outcome

oxidative stress index

total oxidant status

total antioxidant status

Sayı

Yazarlar:

Özgür SÖĞÜT | Halil KAYA | Mehmet Tahir GÖKDEMİR | Leyla SOLDUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.1010-1019

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753942

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144