Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry

Jamıl Anwar; Amara Dar; Ramna Mumtaz; Jesús Anzano; Ayesha Mohyuddin

Makale detayları

Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry

Yazarlar:

Jamıl Anwar | Amara Dar | Ramna Mumtaz | Jesús Anzano | Ayesha Mohyuddin

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 3, pp.1245-1254

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317684

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 Piroxicam is a nonsteroidal anti-inflammatory drug NSAID that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry CISD. Micro-volumes of the aqueous solution of piroxicam were reacted with ironIII sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue RGB components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.

 Piroxicam is a nonsteroidal anti-inflammatory drug NSAID that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry CISD. Micro-volumes of the aqueous solution of piroxicam were reacted with ironIII sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue RGB components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.

 Piroxicam is a nonsteroidal anti-inflammatory drug NSAID that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry CISD. Micro-volumes of the aqueous solution of piroxicam were reacted with ironIII sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue RGB components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.

 Piroxicam is a nonsteroidal anti-inflammatory drug NSAID that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry CISD. Micro-volumes of the aqueous solution of piroxicam were reacted with ironIII sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue RGB components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.

Makale detayları

Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry

Yazarlar:

Jamıl Anwar | Amara Dar | Ramna Mumtaz | Jesús Anzano | Ayesha Mohyuddin

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 3, pp.1245-1254

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317684

pISSN:

2149-0120

Piroxicam asssay

image scanning densitometry

Pharmaceutical analysis

Piroxican estimation

drug assay

Sayı

Makale detayları

Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry

Yazarlar: Jamıl Anwar | Amara Dar | Ramna Mumtaz | Jesús Anzano | Ayesha Mohyuddin

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Analytical Spectrometry

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 3, pp.1245-1254

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001317684

pISSN: 2149-0120

Piroxicam asssay

image scanning densitometry

Pharmaceutical analysis

Piroxican estimation

drug assay

Sayı

Yazarlar:

Jamıl Anwar | Amara Dar | Ramna Mumtaz | Jesús Anzano | Ayesha Mohyuddin

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 3, pp.1245-1254

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317684

pISSN:

2149-0120