Elevated Blood Levels of VEGF Exhibiting Positive Correlation with  HIF-1α in Obesity: A Single Center Study

Nazmiye Uluergüven; Durkadın Demir Ekşi; Erkan Maytalman; Ramazan Güneşaçar

Makale detayları

Elevated Blood Levels of VEGF Exhibiting Positive Correlation with HIF-1α in Obesity: A Single Center Study

Yazarlar:

Nazmiye Uluergüven | Durkadın Demir Ekşi | Erkan Maytalman | Ramazan Güneşaçar

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Beslenme Bilimi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.9 Issue 1, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347391

pISSN:

2587-0335

Anahtar kelimeler:

Özet:

 Aim: The objective of this study was to investigate the relevance of plasma hypoxia-inducible factor-1 alpha HIF-1α and vascular endothelial growth factor VEGF levels in obesity and their associations with body mass index BMI, body fat percentage, and waist to-hip ratio. Material and Methods: The study included 45 obese subjects and 28 healthy controls recruited from a private clinic in Manavgat, Antalya. The measurement of BMI, percentage of body fat, and waist-to-hip ratio was conducted in all subjects using a bioelectrical impedance analysis device. The plasma levels of HIF-1α and VEGF were measured using the micro-ELISA method. Results: In the Mann-Whitney U test, HIF-1α levels were similar in obese subjects median1.439 ngL Interquartile range IQR11.62, min-max0.904-12.53 and control group median1.377 ngL 1.323, 0.852-2.175, p0.0821. VEGF levels were found to be significantly higher in obese subjects compared to the controls medians; 729.8 ngL 5515, 485.3-6000 vs. 589.5 ngL, 416.8, 396.4-813.2, respectively, p0.0001. In Spearman correlation analysis, VEGF and HIF-1α levels were shown to be strongly positively correlated in obese subjects rho0.598, p0.00001. Both the waist-to-hip ratio and body fat percentage also showed significant positive correlations with BMI in the obese group rho0.663, p0.0001 for waist-to-hip ratio, and rho0.313, p0.036 for body fat percentage. In addition, circulating VEGF exhibited strong potential as a biomarker for obesity AUC0.813, p0.001. Conclusion: Elevated plasma levels of VEGF and the strong positive correlation between HIF-1α and VEGF indicate the potential involvement of hypoxia in the progression of obesity. These findings underscore the potential significance of HIF-1α and VEGF in the pathogenesis of obesity. In this study, VEGF was found to be a potential biomarker for obesity.

 Aim: The objective of this study was to investigate the relevance of plasma hypoxia-inducible factor-1 alpha HIF-1α and vascular endothelial growth factor VEGF levels in obesity and their associations with body mass index BMI, body fat percentage, and waist to-hip ratio. Material and Methods: The study included 45 obese subjects and 28 healthy controls recruited from a private clinic in Manavgat, Antalya. The measurement of BMI, percentage of body fat, and waist-to-hip ratio was conducted in all subjects using a bioelectrical impedance analysis device. The plasma levels of HIF-1α and VEGF were measured using the micro-ELISA method. Results: In the Mann-Whitney U test, HIF-1α levels were similar in obese subjects median1.439 ngL Interquartile range IQR11.62, min-max0.904-12.53 and control group median1.377 ngL 1.323, 0.852-2.175, p0.0821. VEGF levels were found to be significantly higher in obese subjects compared to the controls medians; 729.8 ngL 5515, 485.3-6000 vs. 589.5 ngL, 416.8, 396.4-813.2, respectively, p0.0001. In Spearman correlation analysis, VEGF and HIF-1α levels were shown to be strongly positively correlated in obese subjects rho0.598, p0.00001. Both the waist-to-hip ratio and body fat percentage also showed significant positive correlations with BMI in the obese group rho0.663, p0.0001 for waist-to-hip ratio, and rho0.313, p0.036 for body fat percentage. In addition, circulating VEGF exhibited strong potential as a biomarker for obesity AUC0.813, p0.001. Conclusion: Elevated plasma levels of VEGF and the strong positive correlation between HIF-1α and VEGF indicate the potential involvement of hypoxia in the progression of obesity. These findings underscore the potential significance of HIF-1α and VEGF in the pathogenesis of obesity. In this study, VEGF was found to be a potential biomarker for obesity.

 Aim: The objective of this study was to investigate the relevance of plasma hypoxia-inducible factor-1 alpha HIF-1α and vascular endothelial growth factor VEGF levels in obesity and their associations with body mass index BMI, body fat percentage, and waist to-hip ratio. Material and Methods: The study included 45 obese subjects and 28 healthy controls recruited from a private clinic in Manavgat, Antalya. The measurement of BMI, percentage of body fat, and waist-to-hip ratio was conducted in all subjects using a bioelectrical impedance analysis device. The plasma levels of HIF-1α and VEGF were measured using the micro-ELISA method. Results: In the Mann-Whitney U test, HIF-1α levels were similar in obese subjects median1.439 ngL Interquartile range IQR11.62, min-max0.904-12.53 and control group median1.377 ngL 1.323, 0.852-2.175, p0.0821. VEGF levels were found to be significantly higher in obese subjects compared to the controls medians; 729.8 ngL 5515, 485.3-6000 vs. 589.5 ngL, 416.8, 396.4-813.2, respectively, p0.0001. In Spearman correlation analysis, VEGF and HIF-1α levels were shown to be strongly positively correlated in obese subjects rho0.598, p0.00001. Both the waist-to-hip ratio and body fat percentage also showed significant positive correlations with BMI in the obese group rho0.663, p0.0001 for waist-to-hip ratio, and rho0.313, p0.036 for body fat percentage. In addition, circulating VEGF exhibited strong potential as a biomarker for obesity AUC0.813, p0.001. Conclusion: Elevated plasma levels of VEGF and the strong positive correlation between HIF-1α and VEGF indicate the potential involvement of hypoxia in the progression of obesity. These findings underscore the potential significance of HIF-1α and VEGF in the pathogenesis of obesity. In this study, VEGF was found to be a potential biomarker for obesity.

 Amaç: Hipoksi indükleyici faktör 1 alfa HIF-1α ve vasküler endotelyal büyüme faktörü VEGF plazma düzeylerinin obezite ile ilişkisinin ve bu düzeylerin vücut kütle indeksi VKİ, vücut yağ yüzdesi ve belkalça oranı ile ilişkilerinin incelenmesini amaçladık. Gereç ve Yöntemler: Çalışmaya, Antalyanın Manavgat ilçesindeki özel bir klinikten sağlanan 45 obez olgu ve 28 sağlıklı kontrol dahil edildi. Tüm bireylerde VKİ, vücut yağ yüzdesi ve belkalça oranı bir biyoelektrik empedans analiz cihazı kullanılarak ölçüldü. Plazma HIF-1α ve VEGF düzeyleri mikro-ELISA yöntemiyle ölçüldü. Bulgular: Mann-Whitney U testinde, HIF-1α düzeyleri obez bireylerde medyan1,439 ngL Interquartile range IQR11,62 min max0,904-12,53 ve kontrol grubunda medyan1,377 ngL 1,323 0,852-2,175, p0,0821 benzer bulundu. VEGF düzeyleri ise obez bireylerde kontrol grubuna kıyasla anlamlı derecede yüksekti medyan değerleri sırasıyla; 729,8 ngL 5515 485,3-6000e karşın 589,5 ngL, 416,8 396,4-813,2, p0,0001. Spearman korelasyon analizinde, obez olgularda VEGF ve HIF-1α düzeyleri arasında güçlü bir pozitif korelasyon gözlendi rho0,598, p0,00001. Obez grupta belkalça oranı ve vücut yağ yüzdesi de VKİ ile anlamlı pozitif korelasyonlar gösterdi bel kalça oranı için rho0,663, p0,0001; vücut yağ oranı için rho0,313, p0,036. Ayrıca dolaşımdaki VEGF, obezitede güçlü potansiyel bir biyobelirteç olarak belirlendi AUC0,813, p0,001. Sonuç: Yüksek plazma VEGF seviyeleri ve HIF-1α ile VEGF arasındaki güçlü pozitif korelasyon, obezitenin ilerlemesinde hipoksinin potansiyel rolüne işaret etmektedir. Bu bulgular, obezite patogenezinde HIF-1α ve VEGFnin potansiyel önemini vurgulamaktadır. Çalışmamızda VEGFin obezite için potansiyel bir biyobelirteci olduğu gösterilmiştir.

Makale detayları

Elevated Blood Levels of VEGF Exhibiting Positive Correlation with HIF-1α in Obesity: A Single Center Study

Yazarlar:

Nazmiye Uluergüven | Durkadın Demir Ekşi | Erkan Maytalman | Ramazan Güneşaçar

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Beslenme Bilimi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.9 Issue 1, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347391

pISSN:

2587-0335

Obesity

Vascular endothelial growth factor

Hypoxia-inducible factor 1 alpha

Body mass indexObezite

Vasküler endotelyal büyüme faktörü

Hipoksi indükleyici faktör 1 alfa

Vücut kitle indeksi

Sayı

Makale detayları

Yazarlar: Nazmiye Uluergüven | Durkadın Demir Ekşi | Erkan Maytalman | Ramazan Güneşaçar

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Beslenme Bilimi

Dergi: Türkiye Diyabet ve Obezite Dergisi Vol.9 Issue 1, pp.1-8

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347391

pISSN: 2587-0335

Sayı

Yazarlar:

Nazmiye Uluergüven | Durkadın Demir Ekşi | Erkan Maytalman | Ramazan Güneşaçar

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Beslenme Bilimi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.9 Issue 1, pp.1-8

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347391

pISSN:

2587-0335