Neuroprotective potential of the fruit (acorn) from <i>Quercus coccifera</i> L.

Fatma Sezer ŞENOL; Nazım ŞEKEROĞLU; Sevgi GEZİCİ; Esra KILIÇ; İlkay ERDOĞAN ORHAN

Makale detayları

Neuroprotective potential of the fruit (acorn) from <i>Quercus coccifera</i> L.

Yazarlar:

Fatma Sezer ŞENOL | Nazım ŞEKEROĞLU | Sevgi GEZİCİ | Esra KILIÇ | İlkay ERDOĞAN ORHAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Agriculture and Forestry 2018 Vol.42 Issue 2, pp.82-87

Belge Tipi:

Makale

Yayın Tarihi:

4/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000806418

Sıklık:

İki Aylık

eISSN:

1303-6173

pISSN:

1300-011X

Özet:

 

 
                        Neurodegenerative diseases such as Alzheimer disease and Parkinson disease are among the deadly disorders affecting the
elderly population. Unfortunately, effective treatments and medications are still needed to combat these diseases. The ethanol extracts of
the raw peeled acorns and acorn coffees from Quercus coccifera prepared by two different methods (boiled-roasted ground and roasted
ground) were tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR), the enzymes associated
with neurodegeneration. The acorns used in the present study were harvested from wild Quercus coccifera L. trees in Kilis Province,
located in the Eastern Mediterranean region of Turkey in November 2016. Cholinesterase (ChE) and TYR inhibitory activity of the
ethanol extracts prepared from raw material and two coffee samples were screened using an ELISA microtiter assay at 2 mg/mL stock
concentration. Antioxidant effects of the extracts were also tested for their scavenging activity against DPPH, while total phenol and
flavonoid quantities of the extracts were determined spectrophotometrically. Our results indicated that all of the extracts had notable
AChE and BChE inhibition, while they were inactive against TYR. The most active extract against ChEs was prepared from the raw
material, which led to 65.94 ± 3.59% and 85.04 ± 3.83% inhibition against AChE and BChE, respectively. Our data indicate that the fruit
extract from Quercus coccifera is a source of promising ChE inhibitors and deserves future study.

Makale detayları

Neuroprotective potential of the fruit (acorn) from <i>Quercus coccifera</i> L.

Yazarlar: Fatma Sezer ŞENOL | Nazım ŞEKEROĞLU | Sevgi GEZİCİ | Esra KILIÇ | İlkay ERDOĞAN ORHAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Agriculture and Forestry 2018 Vol.42 Issue 2, pp.82-87

Belge Tipi: Makale

Yayın Tarihi: 4/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000806418

Sıklık: İki Aylık

eISSN: 1303-6173

pISSN: 1300-011X

Sayı

Yazarlar:

Fatma Sezer ŞENOL | Nazım ŞEKEROĞLU | Sevgi GEZİCİ | Esra KILIÇ | İlkay ERDOĞAN ORHAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Agriculture and Forestry 2018 Vol.42 Issue 2, pp.82-87

Belge Tipi:

Makale

Yayın Tarihi:

4/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000806418

Sıklık:

İki Aylık

eISSN:

1303-6173

pISSN:

1300-011X