Forty Micromole Hydroxychloroquine Enhanced  Cytotoxic Effect of Doxorubicin Against Laryngeal Cancer  Cell Line HEp-2

N.A.

Makale detayları

Forty Micromole Hydroxychloroquine Enhanced Cytotoxic Effect of Doxorubicin Against Laryngeal Cancer Cell Line HEp-2

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Pharmacy and Pharmacy Practice

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.714-721

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347264

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Autophagy processes are essential biological mechanisms control human cell survival and induction of cell death. Many researches indicate that cancer cells growth is affected by inhibition or induction of autophagy processes and laryngeal cancer the most common type of head and neck cancer is one of various types of tumors which effected by autophagy process. Numerous articles studied impact of adding autophagy inhibiter to cancer treatment protocol, and the current work study the in-vitro anticancer effect of doxorubicin alone and in combination with an autophagy inhibitor agent hydroxychloroquine against HEp-2 laryngeal cancer cell line. The present study suggested valuable effect of doxorubicin anticancer activity against HEp-2 cell line when used after hydroxychloroquine pretreatment, which may play promising role in treatment of laryngeal cancer.

 Autophagy processes are essential biological mechanisms control human cell survival and induction of cell death. Many researches indicate that cancer cells growth is affected by inhibition or induction of autophagy processes and laryngeal cancer the most common type of head and neck cancer is one of various types of tumors which effected by autophagy process. Numerous articles studied impact of adding autophagy inhibiter to cancer treatment protocol, and the current work study the in-vitro anticancer effect of doxorubicin alone and in combination with an autophagy inhibitor agent hydroxychloroquine against HEp-2 laryngeal cancer cell line. The present study suggested valuable effect of doxorubicin anticancer activity against HEp-2 cell line when used after hydroxychloroquine pretreatment, which may play promising role in treatment of laryngeal cancer.

 Autophagy processes are essential biological mechanisms control human cell survival and induction of cell death. Many researches indicate that cancer cells growth is affected by inhibition or induction of autophagy processes and laryngeal cancer the most common type of head and neck cancer is one of various types of tumors which effected by autophagy process. Numerous articles studied impact of adding autophagy inhibiter to cancer treatment protocol, and the current work study the in-vitro anticancer effect of doxorubicin alone and in combination with an autophagy inhibitor agent hydroxychloroquine against HEp-2 laryngeal cancer cell line. The present study suggested valuable effect of doxorubicin anticancer activity against HEp-2 cell line when used after hydroxychloroquine pretreatment, which may play promising role in treatment of laryngeal cancer.

 Autophagy processes are essential biological mechanisms control human cell survival and induction of cell death. Many researches indicate that cancer cells growth is affected by inhibition or induction of autophagy processes and laryngeal cancer the most common type of head and neck cancer is one of various types of tumors which effected by autophagy process. Numerous articles studied impact of adding autophagy inhibiter to cancer treatment protocol, and the current work study the in-vitro anticancer effect of doxorubicin alone and in combination with an autophagy inhibitor agent hydroxychloroquine against HEp-2 laryngeal cancer cell line. The present study suggested valuable effect of doxorubicin anticancer activity against HEp-2 cell line when used after hydroxychloroquine pretreatment, which may play promising role in treatment of laryngeal cancer.

Makale detayları

Forty Micromole Hydroxychloroquine Enhanced Cytotoxic Effect of Doxorubicin Against Laryngeal Cancer Cell Line HEp-2

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Clinical Pharmacy and Pharmacy Practice

Dergi: Journal of Research in Pharmacy Vol.26 Issue 4, pp.714-721

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347264

pISSN: 2630-6344

Autophagy

autophagy inhibitor

doxorubicin

head and neck cancer

HEp-2

hydroxychloroquine

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Pharmacy and Pharmacy Practice

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.714-721

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347264

pISSN:

2630-6344