Immunohistochemical Study on the  PCNA-Immunoreactivity in the Uterus of Rats  Ovariectomized or Treated With Antiestrogen  Clomiphene Citrate

Leyla CANPOLAT

Makale detayları

Immunohistochemical Study on the PCNA-Immunoreactivity in the Uterus of Rats Ovariectomized or Treated With Antiestrogen Clomiphene Citrate

Yazarlar:

Leyla CANPOLAT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.393-400

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757914

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

PCNA (proliferating cell nuclear antigen) immunoreactivity in the uterus of mature rats was investigated after long term administration of clomiphene citrate and ovariectomy. In the luminal epithelium and glandular epithelium and endometrial stroma regions, few PCNA-immunoreactive cells were observed. PCNA reactivity was estimated for the   luminal and glandular epithelium and for the stromal cells. Treatment of clomiphene citrate decreased the proliferation of the luminal epithelial cell and stromal cells to the same extent as ovariectomy. In both of these groups, the proportion of anti-PCNA positive cells in the glandular epithelium was significantly higher than in the luminal epihelium and stromal   cells. Clomiphene citrate has a strong antiproliferative effect on the uterus of rats, and this antiestrogenic action is specific for cell types.

 

PCNA (proliferating cell nuclear antigen) immunoreactivity in the uterus of mature rats was investigated after long term administration of clomiphene citrate and ovariectomy. In the luminal epithelium and glandular epithelium and endometrial stroma regions, few PCNA-immunoreactive cells were observed. PCNA reactivity was estimated for the   luminal and glandular epithelium and for the stromal cells. Treatment of clomiphene citrate decreased the proliferation of the luminal epithelial cell and stromal cells to the same extent as ovariectomy. In both of these groups, the proportion of anti-PCNA positive cells in the glandular epithelium was significantly higher than in the luminal epihelium and stromal   cells. Clomiphene citrate has a strong antiproliferative effect on the uterus of rats, and this antiestrogenic action is specific for cell types.

Makale detayları

Immunohistochemical Study on the PCNA-Immunoreactivity in the Uterus of Rats Ovariectomized or Treated With Antiestrogen Clomiphene Citrate

Yazarlar:

Leyla CANPOLAT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.393-400

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757914

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Clomiphene citrate

Uterus

PCNA immunohistochemistry.

Sayı

Makale detayları

Immunohistochemical Study on the PCNA-Immunoreactivity in the Uterus of Rats Ovariectomized or Treated With Antiestrogen Clomiphene Citrate

Yazarlar: Leyla CANPOLAT

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.393-400

Belge Tipi: Makale

Yayın Tarihi: 3/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757914

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Clomiphene citrate

Uterus

PCNA immunohistochemistry.

Sayı

Yazarlar:

Leyla CANPOLAT

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 4, pp.393-400

Belge Tipi:

Makale

Yayın Tarihi:

3/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757914

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144