A RETROSPECTIVE EVALUATION OF NEOPLASTIC AND NON-NEOPLASTIC PATHOLOGIES IN NON-PREGNANCY ENDOMETRIAL TISSUE SAMPLES AND A LITERATURE REVIEW

Savaş Başar Gül; Sıla Kadıoğlu; Ecem Ömeroğlu; Kaan Gülcan; Gamze Nur Öter; Nedim Polat; Nusret Erdoğan

Makale detayları

A RETROSPECTIVE EVALUATION OF NEOPLASTIC AND NON-NEOPLASTIC PATHOLOGIES IN NON-PREGNANCY ENDOMETRIAL TISSUE SAMPLES AND A LITERATURE REVIEW

Yazarlar:

Savaş Başar Gül | Sıla Kadıoğlu | Ecem Ömeroğlu | Kaan Gülcan | Gamze Nur Öter | Nedim Polat | Nusret Erdoğan

Yayıncı:

Istanbul University

Ana Başlıklar:

Patoloji

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 3, pp.190-197

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356756

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: This study retrospectively examined patients presenting with abnormal uterine bleeding. Based on the histopathological and clinical characteristics of the obtained data, we sought a statistical answer to the question Do age, material type, clinical findings, clinical preliminary, and histopathological diagnosis parameters differ from the literature findings? Material and Methods: A total of 2,000 endometrial samples were reviewed and filtered according to the appropriate parameters collected within 5 years 2017-2022. The statistical significance of the data was measured using the ch-square test. Results: The study included 1,815 patients aged 19 to 86 years. In dications for endometrial sampling were classified as menometrorrhagiamenorrhagia 49.2, endometrial polyp 19.5, post-menopausal bleeding 18, endometrial hyperplasia 14.6, and leiomyoma 2.8. Patients were grouped by menstrual status: premenopausal 51.6, under 45 years, perimenopausal 25.39, aged 45-51, and postmenopausal 22.97, aged 51 and above. Histopathological findings showed benign pathologies including endometrial polyp 61.9, proliferativesecretory endometrium 12, atrophic endometrium 6.6, and chronic endometritis 0.2. The premalignant findings were endometrial hyperplasia without atypia 9 and atypical hyperplasia of the endometrium 0.6. Malignant findings included adenocarcinoma 1.2. Conclusion: An in-depth answer was challenging due to insuffi cient data documentation in the current practice. Nevertheless, we have presented the concordance for the four major pathologies and their distribution in the patient population. Our study has shown that endometrial polyps are the pathology most frequently diagnosed correctly. Our study detected endometrial cancer predominantly in the postmenopausal group, emphasising the importance of endometrial sampling in this group. This aligns with the existing literature.

 Objective: This study retrospectively examined patients presenting with abnormal uterine bleeding. Based on the histopathological and clinical characteristics of the obtained data, we sought a statistical answer to the question Do age, material type, clinical findings, clinical preliminary, and histopathological diagnosis parameters differ from the literature findings? Material and Methods: A total of 2,000 endometrial samples were reviewed and filtered according to the appropriate parameters collected within 5 years 2017-2022. The statistical significance of the data was measured using the ch-square test. Results: The study included 1,815 patients aged 19 to 86 years. In dications for endometrial sampling were classified as menometrorrhagiamenorrhagia 49.2, endometrial polyp 19.5, post-menopausal bleeding 18, endometrial hyperplasia 14.6, and leiomyoma 2.8. Patients were grouped by menstrual status: premenopausal 51.6, under 45 years, perimenopausal 25.39, aged 45-51, and postmenopausal 22.97, aged 51 and above. Histopathological findings showed benign pathologies including endometrial polyp 61.9, proliferativesecretory endometrium 12, atrophic endometrium 6.6, and chronic endometritis 0.2. The premalignant findings were endometrial hyperplasia without atypia 9 and atypical hyperplasia of the endometrium 0.6. Malignant findings included adenocarcinoma 1.2. Conclusion: An in-depth answer was challenging due to insuffi cient data documentation in the current practice. Nevertheless, we have presented the concordance for the four major pathologies and their distribution in the patient population. Our study has shown that endometrial polyps are the pathology most frequently diagnosed correctly. Our study detected endometrial cancer predominantly in the postmenopausal group, emphasising the importance of endometrial sampling in this group. This aligns with the existing literature.

 Objective: This study retrospectively examined patients presenting with abnormal uterine bleeding. Based on the histopathological and clinical characteristics of the obtained data, we sought a statistical answer to the question Do age, material type, clinical findings, clinical preliminary, and histopathological diagnosis parameters differ from the literature findings? Material and Methods: A total of 2,000 endometrial samples were reviewed and filtered according to the appropriate parameters collected within 5 years 2017-2022. The statistical significance of the data was measured using the ch-square test. Results: The study included 1,815 patients aged 19 to 86 years. In dications for endometrial sampling were classified as menometrorrhagiamenorrhagia 49.2, endometrial polyp 19.5, post-menopausal bleeding 18, endometrial hyperplasia 14.6, and leiomyoma 2.8. Patients were grouped by menstrual status: premenopausal 51.6, under 45 years, perimenopausal 25.39, aged 45-51, and postmenopausal 22.97, aged 51 and above. Histopathological findings showed benign pathologies including endometrial polyp 61.9, proliferativesecretory endometrium 12, atrophic endometrium 6.6, and chronic endometritis 0.2. The premalignant findings were endometrial hyperplasia without atypia 9 and atypical hyperplasia of the endometrium 0.6. Malignant findings included adenocarcinoma 1.2. Conclusion: An in-depth answer was challenging due to insuffi cient data documentation in the current practice. Nevertheless, we have presented the concordance for the four major pathologies and their distribution in the patient population. Our study has shown that endometrial polyps are the pathology most frequently diagnosed correctly. Our study detected endometrial cancer predominantly in the postmenopausal group, emphasising the importance of endometrial sampling in this group. This aligns with the existing literature.

 Amaç: Bu çalışmada anormal uterin kanama şikayetiyle gelen hastalar retrospektif olarak olarak incelenmiştir. Elde edilen verilerin histopatolojik ve klinik özelliklerinden yola çıkarak yaş, materyal tipi, klinik bulgular, klinik ön tanı ve histopatolojik tanı parametreleri literatür bulguları ile farklılık gösteriyor mu? sorusuna istatiksel olarak cevap aramak amaçlanmıştır. Gereç ve Yöntemler: Son 5 yılda 2017-2022 gönderilen 2000 adet endometrial örnek taranmıştır ve uygun parametrelere göre filtrelenmiştir. Verilerin istatistiksel anlamlılığı Ki-Kare ile ölçülmüştür. Bulgular: Çalışmadaki 1815 hastanın yaşları 19-86 aralığındadır. Endometrial örnekleme endikasyon sınıflandırması: menometrorajimenoraji 49,2, endometrial polip 19,5 postmenopozal kanama 18, endometrial hiperplazi 14,6 ve leiomyom 2,8 şeklindedir. Menstrüel durumlarına göre; 45 yaş altındaki hastalar premenopoz 51,6, 45-51 yaş arası hastalar perimenopoz 25,39, ve 51 yaş ve üstü hastalar postmenopoz 22,97 şeklinde üç gruba ayrılmıştır. Histopatolojik olarak, benign histopatolojik bulgular arasında endometrial polip 61,9, proliferatifsekretuar endometrium 12, atrofik endometrium 6,6 ve kronik endometrit 0,2 bulunmuştur. Pre-malign bulgularda, atipisiz endometrial hiperplazi 9, ve atipik endometrial hiperplazi 0,6, malign bulgular arasında ise adenokarsinom 1,2 saptanmıştır. Sonuç: Güncel klinik ve laboratuvar pratiğinin sebep olduğu yetersiz veri dokümantasyonu nedeniyle çalışmamızda derinlemesine bir yanıt vermek zor olmuştur. Buna rağmen çalışmamız dört ana patolojinin ön tanı-histopatolojik tanı arasındaki uyumunu ve genel popülasyondaki dağılımını sunmuştur. Endometrial poliplerin en sık doğru teşhis edilen patoloji olduğunu göstermiştir. Çalışmamızda endometrial kanserin ağırlıklı olarak postmenopozal grupta görüldüğü tespit edilmiş olup bu durum, bu grupta endometrial örnekleme yapılmasının önemini vurgulamaktadır. Bu bulgu mevcut literatürle uyumludur.

Makale detayları

A RETROSPECTIVE EVALUATION OF NEOPLASTIC AND NON-NEOPLASTIC PATHOLOGIES IN NON-PREGNANCY ENDOMETRIAL TISSUE SAMPLES AND A LITERATURE REVIEW

Yazarlar:

Savaş Başar Gül | Sıla Kadıoğlu | Ecem Ömeroğlu | Kaan Gülcan | Gamze Nur Öter | Nedim Polat | Nusret Erdoğan

Yayıncı:

Istanbul University

Ana Başlıklar:

Patoloji

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 3, pp.190-197

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356756

pISSN:

1305-6441

Endometrium

histopathology

diagnosisEndometrium

histopatoloji

tanı

Sayı

Makale detayları

A RETROSPECTIVE EVALUATION OF NEOPLASTIC AND NON-NEOPLASTIC PATHOLOGIES IN NON-PREGNANCY ENDOMETRIAL TISSUE SAMPLES AND A LITERATURE REVIEW

Yazarlar: Savaş Başar Gül | Sıla Kadıoğlu | Ecem Ömeroğlu | Kaan Gülcan | Gamze Nur Öter | Nedim Polat | Nusret Erdoğan

Yayıncı: Istanbul University

Ana Başlıklar: Patoloji

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 3, pp.190-197

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001356756

pISSN: 1305-6441

Endometrium

histopathology

diagnosisEndometrium

histopatoloji

tanı

Sayı

Yazarlar:

Savaş Başar Gül | Sıla Kadıoğlu | Ecem Ömeroğlu | Kaan Gülcan | Gamze Nur Öter | Nedim Polat | Nusret Erdoğan

Yayıncı:

Istanbul University

Ana Başlıklar:

Patoloji

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 3, pp.190-197

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356756

pISSN:

1305-6441