Protective and therapeutic effects of hesperidin in an experimental colitis model

Serdal Öğüt; Serdar Aktaş

Makale detayları

Protective and therapeutic effects of hesperidin in an experimental colitis model

Yazarlar:

Serdal Öğüt | Serdar Aktaş

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmaceutical Botany | Pharmaceutical Toxicology

Dergi:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.795-801

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326692

pISSN:

2148-6905

Anahtar kelimeler:

Özet:

 Ulcerative colitis is a gastrointestinal problem with increasing prevalence. In this study, the effect of hesperidin commonly found in citrus white peel on colitis was investigated. For this purpose, 28 Wistar albino female rats, 34 months old and weighing between 250350 g, were used in the study. Rats were randomly divided into four groups: control n7, colitis n7, protective effect n7, and treatment n7 groups. Colitis was induced in rats with acetic acid except control, and hesperidin was then administered at 150 mgkg for 1 week before and after colitis. At the end of the study, IFN-γ and IL-6 values in blood, TAS, TOS, and OSI in tissue were evaluated. Intestinal tissues were assessed visually by haematoxylin and eosin staining. Our results showed that the levels of IFN-γ and IL-6 were highest in the colitis group and lowest in the treatment group, with statistical significance. The most histopathological damage was seen in the colitis group, while less prevalent in the treatment and control groups. The results of the study show that hesperidin had limited protective and therapeutic effects on experimental colitis mouse models.

 Ulcerative colitis is a gastrointestinal problem with increasing prevalence. In this study, the effect of hesperidin commonly found in citrus white peel on colitis was investigated. For this purpose, 28 Wistar albino female rats, 34 months old and weighing between 250350 g, were used in the study. Rats were randomly divided into four groups: control n7, colitis n7, protective effect n7, and treatment n7 groups. Colitis was induced in rats with acetic acid except control, and hesperidin was then administered at 150 mgkg for 1 week before and after colitis. At the end of the study, IFN-γ and IL-6 values in blood, TAS, TOS, and OSI in tissue were evaluated. Intestinal tissues were assessed visually by haematoxylin and eosin staining. Our results showed that the levels of IFN-γ and IL-6 were highest in the colitis group and lowest in the treatment group, with statistical significance. The most histopathological damage was seen in the colitis group, while less prevalent in the treatment and control groups. The results of the study show that hesperidin had limited protective and therapeutic effects on experimental colitis mouse models.

 Ulcerative colitis is a gastrointestinal problem with increasing prevalence. In this study, the effect of hesperidin commonly found in citrus white peel on colitis was investigated. For this purpose, 28 Wistar albino female rats, 34 months old and weighing between 250350 g, were used in the study. Rats were randomly divided into four groups: control n7, colitis n7, protective effect n7, and treatment n7 groups. Colitis was induced in rats with acetic acid except control, and hesperidin was then administered at 150 mgkg for 1 week before and after colitis. At the end of the study, IFN-γ and IL-6 values in blood, TAS, TOS, and OSI in tissue were evaluated. Intestinal tissues were assessed visually by haematoxylin and eosin staining. Our results showed that the levels of IFN-γ and IL-6 were highest in the colitis group and lowest in the treatment group, with statistical significance. The most histopathological damage was seen in the colitis group, while less prevalent in the treatment and control groups. The results of the study show that hesperidin had limited protective and therapeutic effects on experimental colitis mouse models.

 Ulcerative colitis is a gastrointestinal problem with increasing prevalence. In this study, the effect of hesperidin commonly found in citrus white peel on colitis was investigated. For this purpose, 28 Wistar albino female rats, 34 months old and weighing between 250350 g, were used in the study. Rats were randomly divided into four groups: control n7, colitis n7, protective effect n7, and treatment n7 groups. Colitis was induced in rats with acetic acid except control, and hesperidin was then administered at 150 mgkg for 1 week before and after colitis. At the end of the study, IFN-γ and IL-6 values in blood, TAS, TOS, and OSI in tissue were evaluated. Intestinal tissues were assessed visually by haematoxylin and eosin staining. Our results showed that the levels of IFN-γ and IL-6 were highest in the colitis group and lowest in the treatment group, with statistical significance. The most histopathological damage was seen in the colitis group, while less prevalent in the treatment and control groups. The results of the study show that hesperidin had limited protective and therapeutic effects on experimental colitis mouse models.

Makale detayları

Protective and therapeutic effects of hesperidin in an experimental colitis model

Yazarlar:

Serdal Öğüt | Serdar Aktaş

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmaceutical Botany | Pharmaceutical Toxicology

Dergi:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.795-801

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326692

pISSN:

2148-6905

Ulcerative colitis

Hesperidin

Anti-inflammatory effect

AntioxidantUlcerative colitis

Hesperidin

Anti-inflammatory effect

Antioxidant

Sayı

Makale detayları

Yazarlar: Serdal Öğüt | Serdar Aktaş

Yayıncı: İzzet KARA

Ana Başlıklar: Pharmaceutical Botany | Pharmaceutical Toxicology

Dergi: International Journal of Secondary Metabolite Vol.11 Issue 4, pp.795-801

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326692

pISSN: 2148-6905

Sayı

Yazarlar:

Serdal Öğüt | Serdar Aktaş

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmaceutical Botany | Pharmaceutical Toxicology

Dergi:

International Journal of Secondary Metabolite Vol.11 Issue 4, pp.795-801

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326692

pISSN:

2148-6905