Clinical and Laboratory Features of Prolactinoma: Single Center Experience

Duygu Kesebi Isganderov; Nur Kebapçı

Makale detayları

Clinical and Laboratory Features of Prolactinoma: Single Center Experience

Yazarlar:

Duygu Kesebi Isganderov | Nur Kebapçı

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Hipokrat Tıp Dergisi Vol.4 Issue 2, pp.34-39

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001325275

pISSN:

2791-9935

Anahtar kelimeler:

Özet:

 Aim: The aim of our study is to emphasize the importance of epidemiological studies in terms of clinical management of diseases by revealing the frequency, diagnosis, treatment and clinical course of prolactinomas. Materials and Methods: 356 prolactinoma patients were included in the study. The patients information have taken from the hospital information management system and the endocrine files. Scanned information; patient age, gender, age at diagnosis, follow-up year, complaint at presentation, size and location of the adenoma, hormone levels of the pituitary adenoma at the time of diagnosis and after treatment, type of medical treatment used, if any, number and type of operations of the pituitary adenoma, adenoma before and after medical or surgical treatment, size and residualrecurrent pituitary adenoma size, if any, chiasm compression, postoperative hormone activity, and history of RT for adenoma, if any. Results: 356 prolactinoma cases was examined, it was seen that 305 85.7 were female and 51 14.3 were male p0.001. It was observed that 263 73.9 were microadenomas, 63 17.7 were macroadenomas and 30 8.4 were invasive macroadenomas. 6 1.6 of the macroadenomas were recorded as giant adenomas 4cm. Microadenomas were seen more frequently in women 80 p0.001. Macroadenoma was seen in 20 of women and 58 of men p  0.015. Adenoma size and prolactin level were found to be positively correlated at diagnosis r0.318 p0.001. Infertility was observed in 14.4 of women and 7.8 of men p  0.035. Amenorrhea  oligomenorrhea is observed in 66.9 of women; also 28.9 had galactorrhea and 10.5 had hirsutism. Conclusion: The most important results of the study: 1 the incidence of microadenomas is higher than macroadenomas, 2 microadenomas were more common in women, while macroadenomas were detected more frequently in men, 3 adenoma size and prolactin level were found to be positively correlated at the time of diagnosis.

 Aim: The aim of our study is to emphasize the importance of epidemiological studies in terms of clinical management of diseases by revealing the frequency, diagnosis, treatment and clinical course of prolactinomas. Materials and Methods: 356 prolactinoma patients were included in the study. The patients information have taken from the hospital information management system and the endocrine files. Scanned information; patient age, gender, age at diagnosis, follow-up year, complaint at presentation, size and location of the adenoma, hormone levels of the pituitary adenoma at the time of diagnosis and after treatment, type of medical treatment used, if any, number and type of operations of the pituitary adenoma, adenoma before and after medical or surgical treatment, size and residualrecurrent pituitary adenoma size, if any, chiasm compression, postoperative hormone activity, and history of RT for adenoma, if any. Results: 356 prolactinoma cases was examined, it was seen that 305 85.7 were female and 51 14.3 were male p0.001. It was observed that 263 73.9 were microadenomas, 63 17.7 were macroadenomas and 30 8.4 were invasive macroadenomas. 6 1.6 of the macroadenomas were recorded as giant adenomas 4cm. Microadenomas were seen more frequently in women 80 p0.001. Macroadenoma was seen in 20 of women and 58 of men p  0.015. Adenoma size and prolactin level were found to be positively correlated at diagnosis r0.318 p0.001. Infertility was observed in 14.4 of women and 7.8 of men p  0.035. Amenorrhea  oligomenorrhea is observed in 66.9 of women; also 28.9 had galactorrhea and 10.5 had hirsutism. Conclusion: The most important results of the study: 1 the incidence of microadenomas is higher than macroadenomas, 2 microadenomas were more common in women, while macroadenomas were detected more frequently in men, 3 adenoma size and prolactin level were found to be positively correlated at the time of diagnosis.

 Aim: The aim of our study is to emphasize the importance of epidemiological studies in terms of clinical management of diseases by revealing the frequency, diagnosis, treatment and clinical course of prolactinomas. Materials and Methods: 356 prolactinoma patients were included in the study. The patients information have taken from the hospital information management system and the endocrine files. Scanned information; patient age, gender, age at diagnosis, follow-up year, complaint at presentation, size and location of the adenoma, hormone levels of the pituitary adenoma at the time of diagnosis and after treatment, type of medical treatment used, if any, number and type of operations of the pituitary adenoma, adenoma before and after medical or surgical treatment, size and residualrecurrent pituitary adenoma size, if any, chiasm compression, postoperative hormone activity, and history of RT for adenoma, if any. Results: 356 prolactinoma cases was examined, it was seen that 305 85.7 were female and 51 14.3 were male p0.001. It was observed that 263 73.9 were microadenomas, 63 17.7 were macroadenomas and 30 8.4 were invasive macroadenomas. 6 1.6 of the macroadenomas were recorded as giant adenomas 4cm. Microadenomas were seen more frequently in women 80 p0.001. Macroadenoma was seen in 20 of women and 58 of men p  0.015. Adenoma size and prolactin level were found to be positively correlated at diagnosis r0.318 p0.001. Infertility was observed in 14.4 of women and 7.8 of men p  0.035. Amenorrhea  oligomenorrhea is observed in 66.9 of women; also 28.9 had galactorrhea and 10.5 had hirsutism. Conclusion: The most important results of the study: 1 the incidence of microadenomas is higher than macroadenomas, 2 microadenomas were more common in women, while macroadenomas were detected more frequently in men, 3 adenoma size and prolactin level were found to be positively correlated at the time of diagnosis.

 Amaç: Çalışmamızın amacı prolaktinomaların sıklığı, tanı ve tedavisi ile klinik seyrini ortaya koyarak epidemiyolojik çalışmaların hastalıkların klinik yönetimi açısından önemine vurgu yapmaktır. Gereç ve yöntem: 356 prolaktinoma hastası çalışmaya dahil edildi. Hastaların hastane bilgi yönetim sistemi ve hastaların kayıtlı olduğu endokrin dosyalarından bilgileri tarandı. Taranan bilgiler; hasta yaşı, cinsiyet, tanı yaşı, takip yılı, başvuru şikayeti, adenomun boyutu, yerleşimi, hipofiz adenomunun tanı anında ve tedavi sonrası hormon düzeyleri, varsa kullanılan medikal tedavi çeşidi, hipofiz adenomunun operasyon sayısı ve şekli, medikal yada cerrahi tedavi öncesi ile sonrası adenom boyutu ve varsa rezidünüks hipofiz adenom boyutu, kiazma basısı, postop hormon aktivitesi, adenoma yönelik varsa RT öyküsüydü. Bulgular: 356 prolaktinoma olgularının cinsiyet dağılımına bakıldığında 305inin 85.7 kadın, 51inin 14.3 erkek olduğu görüldü p0.001. Radyolojik olarak 263ünün 73.9 mikroadenom, 63ünün 17.7 makroadenom ve 30unun 8.4 invaziv makroadenom olduğu izlendi. Makroadenomların 6 1.6sı dev adenom 4cm olarak kaydedildi. Mikroadenomlar ise kadınlarda daha sık 80 görüldüp0.001. Makroadenom kadınlarda 20 iken, erkeklerde 58 görülmekteydip0.015. Tanı anındaki adenom boyutu ile prolaktin düzeyi pozitif yönde ilişkili bulundur0.318 p0.001. Kadınların 14,4ünde, erkeklerin ise 7.8inde infertilite görüldü p0.035. Kadınların 66.9unda amenore oligomenore görülürken; 28.9 unda galaktore ve 10.5 inde hirşutizm tablosu vardı. Sonuç: Çalışmadan çıkan en önemli sonuçlar: 1 mikroadenomların görülme sıklığı makroadenomlardan daha fazladır,2 kadınlarda mikroadenom daha sık görülerken, erkeklerde ise makroadenom daha sık saptandı,3 tanı anındaki adenom boyutu ile prolaktin düzeyi pozitif yönde ilişkili bulundu.

Makale detayları

Clinical and Laboratory Features of Prolactinoma: Single Center Experience

Yazarlar:

Duygu Kesebi Isganderov | Nur Kebapçı

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Hipokrat Tıp Dergisi Vol.4 Issue 2, pp.34-39

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001325275

pISSN:

2791-9935

Prolactinoma

infertility

microadenom

amenorrhea/oligoamenorrheaProlaktinoma

infertilite

mikroadenomi

amenore/oligoamenore

Sayı

Makale detayları

Yazarlar: Duygu Kesebi Isganderov | Nur Kebapçı

Yayıncı: Bandirma Onyedi Eylul University

Ana Başlıklar: Endokrinoloji

Dergi: Hipokrat Tıp Dergisi Vol.4 Issue 2, pp.34-39

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001325275

pISSN: 2791-9935

Sayı

Yazarlar:

Duygu Kesebi Isganderov | Nur Kebapçı

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Endokrinoloji

Dergi:

Hipokrat Tıp Dergisi Vol.4 Issue 2, pp.34-39

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001325275

pISSN:

2791-9935