Evaluation of the Complete Blood Count Parameters as Prognostic Markers for Remission of Graves’ Disease with Medical Therapy in Children

Diğdem Bezen; Eren Vurgun

Makale detayları

Evaluation of the Complete Blood Count Parameters as Prognostic Markers for Remission of Graves’ Disease with Medical Therapy in Children

Yazarlar:

Diğdem Bezen | Eren Vurgun

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Çocuk Dergisi Vol.23 Issue 2, pp.165-170

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293960

pISSN:

1308-8491

Anahtar kelimeler:

Özet:

 Objective: Graves Disease GD is an autoimmune disease that causes hyperthyroidism. This study intended to find out whether leukocyte, neutrophil, lymphocyte, platelet counts, and neutrophil-to-lymphocyte ratio NLR and systemic immun-inflammation index SII have an association with the remission of GD. Material and Methods: Thirty-seven children who have GD have been included in the study. Anthropometric measurements, physical examination and medical history of patients were recorded. Leukocyte, neutrophil, lymphocyte, platelet counts, NLR and SII at the time of diagnosis and at the end of medical therapy were compared between patients in remission group 1 and patients not in remission group 2. Results: The rate of patients in remission was 54. The presence of palpitation was higher in group 2 than group 1 p0.026. At the time of diagnosis, the leukocyte and neutrophil counts were higher in group 1 p0.001 and p0.014, respectively. While the absence of palpitation increased the rate of remission 6.0 95 CI: 1.1-33.1 times, the rate of remission increased 2.4 95 CI: 1.1-5.2 times as the neutrophil count increased p0.041 and p0.031, respectively. In group 2, there was an increase in leukocyte and neutrophil counts, NLR and SII after medical therapy compared to the levels at the time of diagnosis p0.049, p0.008, p0.002 and p0.001, respectively. Conclusion: Presence of palpitation and lower neutrophil count at the time of diagnosis and increase in leukocyte count, neutrophil count, NLR and SII levels after medical therapy could be prognostic markers for not achieving remission with medical therapy of GD in children.

 Objective: Graves Disease GD is an autoimmune disease that causes hyperthyroidism. This study intended to find out whether leukocyte, neutrophil, lymphocyte, platelet counts, and neutrophil-to-lymphocyte ratio NLR and systemic immun-inflammation index SII have an association with the remission of GD. Material and Methods: Thirty-seven children who have GD have been included in the study. Anthropometric measurements, physical examination and medical history of patients were recorded. Leukocyte, neutrophil, lymphocyte, platelet counts, NLR and SII at the time of diagnosis and at the end of medical therapy were compared between patients in remission group 1 and patients not in remission group 2. Results: The rate of patients in remission was 54. The presence of palpitation was higher in group 2 than group 1 p0.026. At the time of diagnosis, the leukocyte and neutrophil counts were higher in group 1 p0.001 and p0.014, respectively. While the absence of palpitation increased the rate of remission 6.0 95 CI: 1.1-33.1 times, the rate of remission increased 2.4 95 CI: 1.1-5.2 times as the neutrophil count increased p0.041 and p0.031, respectively. In group 2, there was an increase in leukocyte and neutrophil counts, NLR and SII after medical therapy compared to the levels at the time of diagnosis p0.049, p0.008, p0.002 and p0.001, respectively. Conclusion: Presence of palpitation and lower neutrophil count at the time of diagnosis and increase in leukocyte count, neutrophil count, NLR and SII levels after medical therapy could be prognostic markers for not achieving remission with medical therapy of GD in children.

 Objective: Graves Disease GD is an autoimmune disease that causes hyperthyroidism. This study intended to find out whether leukocyte, neutrophil, lymphocyte, platelet counts, and neutrophil-to-lymphocyte ratio NLR and systemic immun-inflammation index SII have an association with the remission of GD. Material and Methods: Thirty-seven children who have GD have been included in the study. Anthropometric measurements, physical examination and medical history of patients were recorded. Leukocyte, neutrophil, lymphocyte, platelet counts, NLR and SII at the time of diagnosis and at the end of medical therapy were compared between patients in remission group 1 and patients not in remission group 2. Results: The rate of patients in remission was 54. The presence of palpitation was higher in group 2 than group 1 p0.026. At the time of diagnosis, the leukocyte and neutrophil counts were higher in group 1 p0.001 and p0.014, respectively. While the absence of palpitation increased the rate of remission 6.0 95 CI: 1.1-33.1 times, the rate of remission increased 2.4 95 CI: 1.1-5.2 times as the neutrophil count increased p0.041 and p0.031, respectively. In group 2, there was an increase in leukocyte and neutrophil counts, NLR and SII after medical therapy compared to the levels at the time of diagnosis p0.049, p0.008, p0.002 and p0.001, respectively. Conclusion: Presence of palpitation and lower neutrophil count at the time of diagnosis and increase in leukocyte count, neutrophil count, NLR and SII levels after medical therapy could be prognostic markers for not achieving remission with medical therapy of GD in children.

 Amaç: Graves hastalığı GH, hipertiroidizme neden olan otoimmün bir hastalıktır. Lökosit, nötrofil, lenfosit, trombosit sayıları ve nötrofil-lenfosit oranı NLO ve sistemik immün-enflamasyon indeksinin SII GH remisyonu ile bir ilişkisi olup olmadığını bulmayı amaçladık. Gereç ve Yöntem: Çalışmaya GH olan otuz yedi çocuk dahil edildi. Hastaların antropometrik ölçümleri, fizik muayeneleri ve tıbbi öyküleri kaydedildi. Remisyonda olan grup 1 ve remisyonda olmayan grup 2 hastaların tanı anında ve medikal tedavi sonunda lökosit, nötrofil, lenfosit, trombosit sayıları, NLO ve SII değerleri karşılaştırıldı. Bulgular: Remisyondaki hasta oranı 54 idi. Çarpıntı varlığı grup 2de grup 1e göre daha yüksekti p0,026. Tanı anında lökosit ve nötrofil sayıları grup 1de daha yüksekti sırasıyla p0,001 ve p0,014. Çarpıntı olmaması remisyon oranını 6,0 95 CI: 1,1-33,1 kat artırırken, nötrofil sayısı arttıkça remisyon oranı 2,4 95 CI: 1,1-5,2 kat artmış olarak bulundu p0,041 ve p sırasıyla 0.031. Grup 2de medikal tedavi sonrası lökosit ve nötrofil sayılarında, NLO ve SIIde tanı anına göre artış saptandı sırasıyla, p0,049, p0,008, p0,002 ve p0,001. Sonuç: Çocuklarda tanı anında çarpıntı olması ve nötrofil sayısının düşük olması, medikal tedavi sonrasında ise lökosit sayısı, nötrofil sayısı, NLO ve SII düzeylerinde artış olması GHda medikal tedavi ile remisyona girmemeye ilişkin prognostik belirteçler olabilir.

Makale detayları

Evaluation of the Complete Blood Count Parameters as Prognostic Markers for Remission of Graves’ Disease with Medical Therapy in Children

Yazarlar:

Diğdem Bezen | Eren Vurgun

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Çocuk Dergisi Vol.23 Issue 2, pp.165-170

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293960

pISSN:

1308-8491

Graves’ Disease

Children

Remission

Prognostic Markers

Neutrophil-To-Lymphocyte Ratio

Systemic Immun-Inflammation IndexGraves Hastaliği

Çocuklar

Remisyon

Prognostik Belirteçler

Nötrofil-Lenfosit Orani

Sistemik Immün-Enflamasyon Indeksi

Sayı

Makale detayları

Yazarlar: Diğdem Bezen | Eren Vurgun

Yayıncı: Istanbul University

Ana Başlıklar: Çocuk Sağlığı ve Hastalıkları

Dergi: Çocuk Dergisi Vol.23 Issue 2, pp.165-170

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293960

pISSN: 1308-8491

Sayı

Yazarlar:

Diğdem Bezen | Eren Vurgun

Yayıncı:

Istanbul University

Ana Başlıklar:

Çocuk Sağlığı ve Hastalıkları

Dergi:

Çocuk Dergisi Vol.23 Issue 2, pp.165-170

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293960

pISSN:

1308-8491