Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Vitaliy SVIRIPA; Michael D. CONROY; Wen ZHANG

Makale detayları

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Yazarlar:

Vitaliy SVIRIPA | Michael D. CONROY | Wen ZHANG

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.473-479

Belge Tipi:

Makale

Yayın Tarihi:

3/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000727359

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Biotinylated analogs of drug candidates provide useful tools for studying   the drug--target protein interactions. Polyhalogenated N,N'diarylureas are   potent activators of adenosine monophosphate-activated kinase (AMPK) and   potentially promising agents for the treatment of cancer. Various   biotinylated versions of these N,N'-diarylureas were synthesized and   evaluated in AMPK-activation studies.

 

Biotinylated analogs of drug candidates provide useful tools for studying   the drug--target protein interactions. Polyhalogenated N,N'diarylureas are   potent activators of adenosine monophosphate-activated kinase (AMPK) and   potentially promising agents for the treatment of cancer. Various   biotinylated versions of these N,N'-diarylureas were synthesized and   evaluated in AMPK-activation studies.

Makale detayları

Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Yazarlar: Vitaliy SVIRIPA | Michael D. CONROY | Wen ZHANG

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.473-479

Belge Tipi: Makale

Yayın Tarihi: 3/2013

Belge Dili: Türkçe

Document ID (Org No.): 2000727359

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Vitaliy SVIRIPA | Michael D. CONROY | Wen ZHANG

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2013 Vol.37 Issue 4, pp.473-479

Belge Tipi:

Makale

Yayın Tarihi:

3/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000727359

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527