The impact of pre-transplant fibrinogen and D-dimer levels on transplantation outcomes in autologous stem cell transplantation

Neslihan Mandacı Şanlı; Edanur Dilara Mandacı

Makale detayları

The impact of pre-transplant fibrinogen and D-dimer levels on transplantation outcomes in autologous stem cell transplantation

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.621-628

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355841

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: Determine how serum D-dimer and fibrinogen levels affect the prognosis of patients undergoing autologous hematopoietic stem cell transplantation auto-HSCT within the context of underlying hematologic malignancies. Methods: This retrospective study included 152 adult patients who received auto-HSCT between 2010 and 2024. D-dimer and fibrinogen levels were documented prior to the transplant. Survival analyses were performed with Kaplan-Meier curves and Cox regression methods. ROC analysis provided cut-off values. Results: The D-dimer and fibrinogen cut-off levels of 860 ngml and 448 mgdl, respectively, were statistically significant with increased rates of relapse and mortality. Mortality was independently predicted by D-dimer and fibrinogen HR: 96.74 and 5.478 and relapse HR: 24.254 and 6.921. Increased levels of the markers significantly reduced the five-year overall survival. Conclusion: Auto-HSCT patients with elevated D-dimer and fibrinogen have unfavorable prognoses and poor outcomes. The inexpensive nature of these biomarkers allows greater ease in establishing risk stratification for targeted pre-transplant planning.

 Aims: Determine how serum D-dimer and fibrinogen levels affect the prognosis of patients undergoing autologous hematopoietic stem cell transplantation auto-HSCT within the context of underlying hematologic malignancies. Methods: This retrospective study included 152 adult patients who received auto-HSCT between 2010 and 2024. D-dimer and fibrinogen levels were documented prior to the transplant. Survival analyses were performed with Kaplan-Meier curves and Cox regression methods. ROC analysis provided cut-off values. Results: The D-dimer and fibrinogen cut-off levels of 860 ngml and 448 mgdl, respectively, were statistically significant with increased rates of relapse and mortality. Mortality was independently predicted by D-dimer and fibrinogen HR: 96.74 and 5.478 and relapse HR: 24.254 and 6.921. Increased levels of the markers significantly reduced the five-year overall survival. Conclusion: Auto-HSCT patients with elevated D-dimer and fibrinogen have unfavorable prognoses and poor outcomes. The inexpensive nature of these biomarkers allows greater ease in establishing risk stratification for targeted pre-transplant planning.

 Aims: Determine how serum D-dimer and fibrinogen levels affect the prognosis of patients undergoing autologous hematopoietic stem cell transplantation auto-HSCT within the context of underlying hematologic malignancies. Methods: This retrospective study included 152 adult patients who received auto-HSCT between 2010 and 2024. D-dimer and fibrinogen levels were documented prior to the transplant. Survival analyses were performed with Kaplan-Meier curves and Cox regression methods. ROC analysis provided cut-off values. Results: The D-dimer and fibrinogen cut-off levels of 860 ngml and 448 mgdl, respectively, were statistically significant with increased rates of relapse and mortality. Mortality was independently predicted by D-dimer and fibrinogen HR: 96.74 and 5.478 and relapse HR: 24.254 and 6.921. Increased levels of the markers significantly reduced the five-year overall survival. Conclusion: Auto-HSCT patients with elevated D-dimer and fibrinogen have unfavorable prognoses and poor outcomes. The inexpensive nature of these biomarkers allows greater ease in establishing risk stratification for targeted pre-transplant planning.

 Amaç: Bu çalışmada, hematolojik maligniteler bağlamında otolog hematopoetik kök hücre transplantasyonu auto-HSCT uygulanan hastalarda serum D-dimer ve fibrinojen düzeylerinin prognoz üzerindeki etkisinin değerlendirilmesi amaçlanmıştır. Yöntemler: Bu retrospektif çalışmaya 2010 ile 2024 yılları arasında auto-HSCT uygulanan 152 yetişkin hasta dahil edilmiştir. Transplantasyon öncesi D-dimer ve fibrinojen düzeyleri kaydedilmiştir. Sağkalım analizleri KaplanMeier eğrileri ve Cox regresyon yöntemleriyle yapılmıştır. ROC analizi ile eşik değerler belirlenmiştir. Bulgular: D-dimer ve fibrinojen için sırasıyla 860 ngmL ve 448 mgdL eşik değerleri, artmış nüks ve mortalite oranları ile istatistiksel olarak anlamlı bulunmuştur. D-dimer ve fibrinojen düzeyleri mortalite HR: 96.74 ve 5.478 ve nüks HR: 24.254 ve 6.921 açısından bağımsız prediktörler olarak belirlenmiştir. Bu biyobelirteçlerin yüksek seviyeleri, beş yıllık genel sağkalım oranlarını anlamlı şekilde azaltmıştır. Sonuç: Yüksek D-dimer ve fibrinojen düzeylerine sahip auto-HSCT hastalarının prognozu olumsuzdur ve transplantasyon sonuçları kötüdür. Bu biyobelirteçlerin ucuz ve erişilebilir olması, transplantasyon öncesi risk sınıflaması yapılarak hedefe yönelik tedavi planlamasında kolaylık sağlar.

Makale detayları

The impact of pre-transplant fibrinogen and D-dimer levels on transplantation outcomes in autologous stem cell transplantation

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.621-628

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355841

pISSN:

2636-8579

Autologous stem cell transplantation

D-dimer

fibrinogen

prognosis

hematologic malignancyOtolog kök hücre transplantasyonu

D-dimer

Fibrinojen

Prognoz

Hematolojik malignite

Sayı

Makale detayları

Yazarlar: Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Hematoloji

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.621-628

Belge Tipi: Makale

Yayın Tarihi: 7/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001355841

pISSN: 2636-8579

Sayı

Yazarlar:

Neslihan Mandacı Şanlı | Edanur Dilara Mandacı

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Hematoloji

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 4, pp.621-628

Belge Tipi:

Makale

Yayın Tarihi:

7/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001355841

pISSN:

2636-8579