Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental Schiff bases containing indole and resorcinol moieties

Mahendra Raj KAREKAL; Mruthyunjayaswamy BENNIKALLU HIRE MATHADA

doi:https://doi.org/10.3906/kim-1303-28

Makale detayları

Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental Schiff bases containing indole and resorcinol moieties

Yazarlar:

Mahendra Raj KAREKAL | Mruthyunjayaswamy BENNIKALLU HIRE MATHADA

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2013 Vol.37 Issue 5, pp.775-795

Belge Tipi:

Makale

Yayın Tarihi:

4/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000727335

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1303-28

Özet:

 

A series of binucleating Cu(II), Ni(II), and Zn(II)   complexes of bicompartmental ligands with ONO donors were prepared.   The ligands were synthesized by the condensation of   5-substituted-3-phenyl-1H-indole-2-carboxyhydrazides and   4,6-diacetylresorcinol. The newly synthesized ligands and their complexes   were characterized by elemental analysis and various spectral studies like   IR, 1H NMR, ESI-mass, UV-Vis, ESR, thermal studies, magnetic   susceptibility, molar conductance, and powder-XRD data. All the complexes   were binuclear and monomeric in nature. Cu(II) complexes have octahedral   geometry, whereas Ni(II) and Zn(II) complexes have square planar and   tetrahedral geometry, respectively. The redox property of the Cu(II) complex   was investigated by electrochemical method using cyclic voltammetry. In   order to evaluate the effect of metal ions upon chelation, both the ligands   and their metal complexes were screened for their antibacterial and   antifungal activities by minimum   inhibitory concentration (MIC) method. The DNA cleaving capacity of all the   complexes was analyzed by agarose gel electrophoresis.

 

A series of binucleating Cu(II), Ni(II), and Zn(II)   complexes of bicompartmental ligands with ONO donors were prepared.   The ligands were synthesized by the condensation of   5-substituted-3-phenyl-1H-indole-2-carboxyhydrazides and   4,6-diacetylresorcinol. The newly synthesized ligands and their complexes   were characterized by elemental analysis and various spectral studies like   IR, 1H NMR, ESI-mass, UV-Vis, ESR, thermal studies, magnetic   susceptibility, molar conductance, and powder-XRD data. All the complexes   were binuclear and monomeric in nature. Cu(II) complexes have octahedral   geometry, whereas Ni(II) and Zn(II) complexes have square planar and   tetrahedral geometry, respectively. The redox property of the Cu(II) complex   was investigated by electrochemical method using cyclic voltammetry. In   order to evaluate the effect of metal ions upon chelation, both the ligands   and their metal complexes were screened for their antibacterial and   antifungal activities by minimum   inhibitory concentration (MIC) method. The DNA cleaving capacity of all the   complexes was analyzed by agarose gel electrophoresis.

Makale detayları

Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental Schiff bases containing indole and resorcinol moieties

Yazarlar: Mahendra Raj KAREKAL | Mruthyunjayaswamy BENNIKALLU HIRE MATHADA

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2013 Vol.37 Issue 5, pp.775-795

Belge Tipi: Makale

Yayın Tarihi: 4/2013

Belge Dili: İngilizce

Document ID (Org No.): 2000727335

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1303-28

Sayı

Yazarlar:

Mahendra Raj KAREKAL | Mruthyunjayaswamy BENNIKALLU HIRE MATHADA

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2013 Vol.37 Issue 5, pp.775-795

Belge Tipi:

Makale

Yayın Tarihi:

4/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000727335

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1303-28