Optimization of HPMC Loaded Paroxetine HCl Controlled Release Matrix Tablet by Central Composite Design

Komal Parmar; Mehul Patel; Punitkumar Bhatt; Tejal Soni; Bhanubhai Suhagia

Makale detayları

Optimization of HPMC Loaded Paroxetine HCl Controlled Release Matrix Tablet by Central Composite Design

Yazarlar:

Komal Parmar | Mehul Patel | Punitkumar Bhatt | Tejal Soni | Bhanubhai Suhagia

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Sciences | Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.44 Issue 4, pp.289-305

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332479

pISSN:

2458-8806

Anahtar kelimeler:

Özet:

 The main aim of the present study was to improve the release profile of Paroxetine PXT using Novel Drug Delivery System NDDS. Therefore, Controlled Release Matrix tablet of PXT was prepared to extend the release of the drug from 8 hours to 12 hours. In the present research work, controlled release matrix tablet of paroxetine PXT was prepared by wet granulation method using various polymer grades of Hydroxypropyl methylcellulose HPMC and Polyvinylpyrrolidone PVP like HPMC K100M, HPMC K4M, HPMC K100M LV, and PVP K-30. Central Composite Design was applied to optimize the amount of polymers in the tablet. Infrared Spectroscopic analysis was done to check the interaction between drug and polymers. Results showed that all pre-compression and post-compression parameters were as per standard limits and not deviated when compared with the marketed formulation. The release profile of the tablet formulated using optimized batch was also improved significantly. Specifically, PXT matrix tablet released approximately 29.382, 41.29, and 93.47 of the drug at the second, fourth, and twelfth hours, respectively. In conclusion, the dissolution profile of the optimized batch aligns closely with the established USP guidelines for PXT extended-release formulations.

 The main aim of the present study was to improve the release profile of Paroxetine PXT using Novel Drug Delivery System NDDS. Therefore, Controlled Release Matrix tablet of PXT was prepared to extend the release of the drug from 8 hours to 12 hours. In the present research work, controlled release matrix tablet of paroxetine PXT was prepared by wet granulation method using various polymer grades of Hydroxypropyl methylcellulose HPMC and Polyvinylpyrrolidone PVP like HPMC K100M, HPMC K4M, HPMC K100M LV, and PVP K-30. Central Composite Design was applied to optimize the amount of polymers in the tablet. Infrared Spectroscopic analysis was done to check the interaction between drug and polymers. Results showed that all pre-compression and post-compression parameters were as per standard limits and not deviated when compared with the marketed formulation. The release profile of the tablet formulated using optimized batch was also improved significantly. Specifically, PXT matrix tablet released approximately 29.382, 41.29, and 93.47 of the drug at the second, fourth, and twelfth hours, respectively. In conclusion, the dissolution profile of the optimized batch aligns closely with the established USP guidelines for PXT extended-release formulations.

 The main aim of the present study was to improve the release profile of Paroxetine PXT using Novel Drug Delivery System NDDS. Therefore, Controlled Release Matrix tablet of PXT was prepared to extend the release of the drug from 8 hours to 12 hours. In the present research work, controlled release matrix tablet of paroxetine PXT was prepared by wet granulation method using various polymer grades of Hydroxypropyl methylcellulose HPMC and Polyvinylpyrrolidone PVP like HPMC K100M, HPMC K4M, HPMC K100M LV, and PVP K-30. Central Composite Design was applied to optimize the amount of polymers in the tablet. Infrared Spectroscopic analysis was done to check the interaction between drug and polymers. Results showed that all pre-compression and post-compression parameters were as per standard limits and not deviated when compared with the marketed formulation. The release profile of the tablet formulated using optimized batch was also improved significantly. Specifically, PXT matrix tablet released approximately 29.382, 41.29, and 93.47 of the drug at the second, fourth, and twelfth hours, respectively. In conclusion, the dissolution profile of the optimized batch aligns closely with the established USP guidelines for PXT extended-release formulations.

 The main aim of the present study was to improve the release profile of Paroxetine PXT using Novel Drug Delivery System NDDS. Therefore, Controlled Release Matrix tablet of PXT was prepared to extend the release of the drug from 8 hours to 12 hours. In the present research work, controlled release matrix tablet of paroxetine PXT was prepared by wet granulation method using various polymer grades of Hydroxypropyl methylcellulose HPMC and Polyvinylpyrrolidone PVP like HPMC K100M, HPMC K4M, HPMC K100M LV, and PVP K-30. Central Composite Design was applied to optimize the amount of polymers in the tablet. Infrared Spectroscopic analysis was done to check the interaction between drug and polymers. Results showed that all pre-compression and post-compression parameters were as per standard limits and not deviated when compared with the marketed formulation. The release profile of the tablet formulated using optimized batch was also improved significantly. Specifically, PXT matrix tablet released approximately 29.382, 41.29, and 93.47 of the drug at the second, fourth, and twelfth hours, respectively. In conclusion, the dissolution profile of the optimized batch aligns closely with the established USP guidelines for PXT extended-release formulations.

Makale detayları

Optimization of HPMC Loaded Paroxetine HCl Controlled Release Matrix Tablet by Central Composite Design

Yazarlar:

Komal Parmar | Mehul Patel | Punitkumar Bhatt | Tejal Soni | Bhanubhai Suhagia

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Sciences | Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.44 Issue 4, pp.289-305

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332479

pISSN:

2458-8806

Paroxetine HCl

HPMC K4M

HPMC K100M

Dissolution

kineticsParoksetin HCl

HPMC K4M

HPMC K100M

Çözünme

Kinetik

Sayı

Makale detayları

Yazarlar: Komal Parmar | Mehul Patel | Punitkumar Bhatt | Tejal Soni | Bhanubhai Suhagia

Yayıncı: Hacettepe University

Ana Başlıklar: Pharmaceutical Sciences | Pharmaceutical Delivery Technologies

Dergi: Hacettepe University Journal of the Faculty of Pharmacy Vol.44 Issue 4, pp.289-305

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001332479

pISSN: 2458-8806

Sayı

Yazarlar:

Komal Parmar | Mehul Patel | Punitkumar Bhatt | Tejal Soni | Bhanubhai Suhagia

Yayıncı:

Hacettepe University

Ana Başlıklar:

Pharmaceutical Sciences | Pharmaceutical Delivery Technologies

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy Vol.44 Issue 4, pp.289-305

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332479

pISSN:

2458-8806