Relation of total homocysteine level with metabolic and anthropometric variables in obese children and adolescents

Ayhan ABACI; Ahmet Zülfikar AKELMA; Osman ÖZDEMİR; Şamil HIZLI; Cem Hasan RAZİ; Kadir Okhan AKIN

Makale detayları

Relation of total homocysteine level with metabolic and anthropometric variables in obese children and adolescents

Yazarlar:

Ayhan ABACI | Ahmet Zülfikar AKELMA | Osman ÖZDEMİR | Şamil HIZLI | Cem Hasan RAZİ | Kadir Okhan AKIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 1, pp.69-76

Belge Tipi:

Makale

Yayın Tarihi:

12/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754290

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated.  Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile.     Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from the obese group and the control group revealed that the differences in BMI, BMI standard deviation score, tHcy, total cholesterol, triglyceride (TG), insulin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and homeostasis model assessment-insulin resistance (HOMA-IR) levels were statistically significant (P < 0.05). In the obese group, the tHcy level was statistically significantly correlated with age and BMI, TG, and HDL levels (P   0.05).  Conclusion: The results of this study showed that the tHcy level was higher in obese children than in healthy children. However, the tHcy level was not significantly correlated with insulin resistance in obese children. Obese children should be routinely screened for high tHcy levels due to the potential atherosclerosis risks, and patients with high tHcy levels should be treated.

 

To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated.  Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile.     Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from the obese group and the control group revealed that the differences in BMI, BMI standard deviation score, tHcy, total cholesterol, triglyceride (TG), insulin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and homeostasis model assessment-insulin resistance (HOMA-IR) levels were statistically significant (P < 0.05). In the obese group, the tHcy level was statistically significantly correlated with age and BMI, TG, and HDL levels (P   0.05).  Conclusion: The results of this study showed that the tHcy level was higher in obese children than in healthy children. However, the tHcy level was not significantly correlated with insulin resistance in obese children. Obese children should be routinely screened for high tHcy levels due to the potential atherosclerosis risks, and patients with high tHcy levels should be treated.

Makale detayları

Relation of total homocysteine level with metabolic and anthropometric variables in obese children and adolescents

Yazarlar:

Ayhan ABACI | Ahmet Zülfikar AKELMA | Osman ÖZDEMİR | Şamil HIZLI | Cem Hasan RAZİ | Kadir Okhan AKIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 1, pp.69-76

Belge Tipi:

Makale

Yayın Tarihi:

12/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754290

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Atherosclerosis

homocysteine

insulin resistance

obesity

puberty

Sayı

Makale detayları

Relation of total homocysteine level with metabolic and anthropometric variables in obese children and adolescents

Yazarlar: Ayhan ABACI | Ahmet Zülfikar AKELMA | Osman ÖZDEMİR | Şamil HIZLI | Cem Hasan RAZİ | Kadir Okhan AKIN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2012 Vol.42 Issue 1, pp.69-76

Belge Tipi: Makale

Yayın Tarihi: 12/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000754290

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Atherosclerosis

homocysteine

insulin resistance

obesity

puberty

Sayı

Yazarlar:

Ayhan ABACI | Ahmet Zülfikar AKELMA | Osman ÖZDEMİR | Şamil HIZLI | Cem Hasan RAZİ | Kadir Okhan AKIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 1, pp.69-76

Belge Tipi:

Makale

Yayın Tarihi:

12/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754290

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144