Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

N.A.

Makale detayları

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.145-153

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346112

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol 50 methanol was used as the solvent for extraction. Streptozotocin 55 mgkg, i.p induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina HABEA for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA 200 and 400 mgkg, p.o treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior Hot Plate Method and Tail Immersion Method and locomotor behavior actophotometer were significantly improved in HABEA 200 and 400 mgkg, p.o treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

 Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol 50 methanol was used as the solvent for extraction. Streptozotocin 55 mgkg, i.p induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina HABEA for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA 200 and 400 mgkg, p.o treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior Hot Plate Method and Tail Immersion Method and locomotor behavior actophotometer were significantly improved in HABEA 200 and 400 mgkg, p.o treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

 Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol 50 methanol was used as the solvent for extraction. Streptozotocin 55 mgkg, i.p induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina HABEA for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA 200 and 400 mgkg, p.o treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior Hot Plate Method and Tail Immersion Method and locomotor behavior actophotometer were significantly improved in HABEA 200 and 400 mgkg, p.o treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

 Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective activity of bark of Adenanthera pavonina. Hydro alcohol 50 methanol was used as the solvent for extraction. Streptozotocin 55 mgkg, i.p induced diabetic rats were used for the evaluation of antihyperglycemic and neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina HABEA for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase levels were decreased significantly in HABEA 200 and 400 mgkg, p.o treated rats. However, body weight, Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as pain behavior Hot Plate Method and Tail Immersion Method and locomotor behavior actophotometer were significantly improved in HABEA 200 and 400 mgkg, p.o treated rats. These are the findings confirms that, the HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin, phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and determining its molecular mechanisms.

Makale detayları

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.145-153

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346112

pISSN:

2630-6344

Diabetes

glutamate;

behavioral

herbal medicine

diabetic neuropathy

Sayı

Makale detayları

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.26 Issue 1, pp.145-153

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346112

pISSN: 2630-6344

Diabetes

glutamate;

behavioral

herbal medicine

diabetic neuropathy

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.145-153

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346112

pISSN:

2630-6344