Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives

Fatih TOK; Cansel ÇAKIR; Dilaycan ÇAM; Mustafa Murat KIRPAT; Yusuf SICAK

doi:https://doi.org/10.33808/clinexphealthsci.1062872

Makale detayları

Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives

Yazarlar:

Fatih TOK | Cansel ÇAKIR | Dilaycan ÇAM | Mustafa Murat KIRPAT | Yusuf SICAK

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2022 Vol.12 Issue 2, pp.533-540

Belge Tipi:

Makale

Yayın Tarihi:

6/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000906580

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.1062872

Özet:

 

Objective: A new series of 4-[3-(substitutedphenyl)thioureido]-N-(6-chloropyrazin-2-yl)benzenesulfonamide were synthesized from sulfaclozine. 
Methods: All compounds were characterized by IR, 1H-NMR spectroscopic methods and elemental analysis. In addition to the antioxidant activity of the synthesis series, enzyme inhibition activities such as anticholinesterase, tyrosinase, α-amylase and α-glycosidase were determined for the first time in this study. 
Results: According to these biological activity test results, compound 2a in the DPPH, 2c in the ABTS˙+ assay exhibited more antioxidant activity than reference standard. All thiourea derivatives demonstrated good BChE inhibitory activity than galantamine. Among the compounds, 2e and 2f showed the best tyrosinase enzyme inhibition activity, while 2g had the best α-amylase and α-glucosidase enzyme inhibition activity. In addition, we evaluated the druglikeness properties of compounds and their oral bioavailability were also found to be high.
Conclusion: Thiourea derivatives exhibited remarkable antioxidant activity and enzyme inhibition activity against tyrosinase, cholinesterase, α-amylase and α-glucosidase.

Makale detayları

Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives

Yazarlar: Fatih TOK | Cansel ÇAKIR | Dilaycan ÇAM | Mustafa Murat KIRPAT | Yusuf SICAK

Yayıncı: Marmara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Clinical and Experimental Health Sciences 2022 Vol.12 Issue 2, pp.533-540

Belge Tipi: Makale

Yayın Tarihi: 6/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000906580

Sıklık: Aylık

eISSN: 2459-1459

DOI: https://doi.org/10.33808/clinexphealthsci.1062872

Sayı

Yazarlar:

Fatih TOK | Cansel ÇAKIR | Dilaycan ÇAM | Mustafa Murat KIRPAT | Yusuf SICAK

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2022 Vol.12 Issue 2, pp.533-540

Belge Tipi:

Makale

Yayın Tarihi:

6/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000906580

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.1062872