Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Mehmet ALP; Ali Hakan GÖKER; Nurten ALTANLAR

Makale detayları

Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Yazarlar:

Mehmet ALP | Ali Hakan GÖKER | Nurten ALTANLAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 1, pp.152-156

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000727265

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

 

A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.

Makale detayları

Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Yazarlar: Mehmet ALP | Ali Hakan GÖKER | Nurten ALTANLAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2014 Vol.38 Issue 1, pp.152-156

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000727265

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mehmet ALP | Ali Hakan GÖKER | Nurten ALTANLAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2014 Vol.38 Issue 1, pp.152-156

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000727265

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527