Effects of phenytoin injection on vocal cord healing after mechanical trauma: An experimental study

Sibel Alicura TOKGÖZ; Cem SAKA; İstemihan AKIN; Fatma Fulya KÖYBAŞIOĞLU; Saffet KILIÇASLAN; Murat ÇALIŞKAN; Ömer BEŞALTI; Emel Çadalli TATAR

Makale detayları

Effects of phenytoin injection on vocal cord healing after mechanical trauma: An experimental study

Yazarlar:

Sibel Alicura TOKGÖZ | Cem SAKA | İstemihan AKIN | Fatma Fulya KÖYBAŞIOĞLU | Saffet KILIÇASLAN | Murat ÇALIŞKAN | Ömer BEŞALTI | Emel Çadalli TATAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1577-1581

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749935

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Phenytoin  is  an  anticonvulsant  drug  which  causes  fibroblast  proliferation,  collagen  synthesis,  and  an  increase  in  epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: Thickness of the lamina propria was 18.0 ± 7.1 ?m in the control group, 65.5 ± 10.7 ?m in the phenytoin group. The density of fibroblast and collagen were statistically lower in the control group compared the phenytoin group (P < 0.05).Conclusion: Phenytoin injection in rats after vocal cord injury significantly increased the thickness of the lamina propria and density of fibroblast and regular and mature collagen in the lamina propria. The findings in our study provide a feasible scientific view for adding phenytoin treatment to vocal cord surgeries in otolaryngology practice, but further studies are needed in order to evaluate the use of phenytoin in preventing the formation of scar tissue and possible effects on vocal cord vibration in humans after vocal cord injury.

Makale detayları

Effects of phenytoin injection on vocal cord healing after mechanical trauma: An experimental study

Yazarlar: Sibel Alicura TOKGÖZ | Cem SAKA | İstemihan AKIN | Fatma Fulya KÖYBAŞIOĞLU | Saffet KILIÇASLAN | Murat ÇALIŞKAN | Ömer BEŞALTI | Emel Çadalli TATAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1577-1581

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749935

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Sibel Alicura TOKGÖZ | Cem SAKA | İstemihan AKIN | Fatma Fulya KÖYBAŞIOĞLU | Saffet KILIÇASLAN | Murat ÇALIŞKAN | Ömer BEŞALTI | Emel Çadalli TATAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1577-1581

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749935

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144