ROLE OF THE DUCTUS THORACICUS IN PULMONARY FAT EMBOLISM AFTER SUBARACHNOID HAEMORRHAGE: A PRELIMINARY EXPERIMENTAL STUDY

Hakan Kına; Muhammet Elveren

Makale detayları

ROLE OF THE DUCTUS THORACICUS IN PULMONARY FAT EMBOLISM AFTER SUBARACHNOID HAEMORRHAGE: A PRELIMINARY EXPERIMENTAL STUDY

Yazarlar:

Hakan Kına | Muhammet Elveren

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.14-19

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341400

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: Subarachnoid haemorrhage is a multisystemic disease due to its effects on the autonomic nervous system. Pulmonary tissues may be affected due to its effects on the intestinal system, lipid metabolism, and ductus thoracicus in subarachnoid haemorrhage. This study demonstrate the pathophysiology of pulmonary fat embolism after sympathetic activation of the ductus thoracicus with lipid absorption disorders after subarachnoid haemorrhage. Material and Methods: In the study, 24 male rabbits were used, of which five were selected as the control group GI and five as the SHAM group GII. The SHAM group was injected with a 0.7 mL isotonic solution into the cisterna magna. The study group GIII was injected with 0.7 mL autologous blood into the cisterna magna. The lymphatic vessels in the middle sections of the duodenum, the thoracic duct portions opening into the jugular vein, and the terminal branches of the pulmonary arteries were examined and counted. Results: The thoracic duct vasospasm index VSI values and numbers of branches occluded by fat particles in the pulmonary arteries were: 1.650.223.210.54 in GI, 1.970.347.32.4 in GII, and 2.540.5614.5314.53 in GIII. In the six subjects with severe thoracic duct spasm in GIII, the number of pulmonary arteries occluded with chylomicrons was higher p0.00001. P values among groups were: p 0.05 in GIGII; p0.005 in GIIGIII and p0.0001 in GIGIII. Conclusion: This is the first experimental study conducted on animals investigating the lipid metabolism disorder associated with subarachnoid haemorrhage affecting the cervical ganglia, thoracic duct spasm, and pulmonary fat embolism.

 Objective: Subarachnoid haemorrhage is a multisystemic disease due to its effects on the autonomic nervous system. Pulmonary tissues may be affected due to its effects on the intestinal system, lipid metabolism, and ductus thoracicus in subarachnoid haemorrhage. This study demonstrate the pathophysiology of pulmonary fat embolism after sympathetic activation of the ductus thoracicus with lipid absorption disorders after subarachnoid haemorrhage. Material and Methods: In the study, 24 male rabbits were used, of which five were selected as the control group GI and five as the SHAM group GII. The SHAM group was injected with a 0.7 mL isotonic solution into the cisterna magna. The study group GIII was injected with 0.7 mL autologous blood into the cisterna magna. The lymphatic vessels in the middle sections of the duodenum, the thoracic duct portions opening into the jugular vein, and the terminal branches of the pulmonary arteries were examined and counted. Results: The thoracic duct vasospasm index VSI values and numbers of branches occluded by fat particles in the pulmonary arteries were: 1.650.223.210.54 in GI, 1.970.347.32.4 in GII, and 2.540.5614.5314.53 in GIII. In the six subjects with severe thoracic duct spasm in GIII, the number of pulmonary arteries occluded with chylomicrons was higher p0.00001. P values among groups were: p 0.05 in GIGII; p0.005 in GIIGIII and p0.0001 in GIGIII. Conclusion: This is the first experimental study conducted on animals investigating the lipid metabolism disorder associated with subarachnoid haemorrhage affecting the cervical ganglia, thoracic duct spasm, and pulmonary fat embolism.

 Objective: Subarachnoid haemorrhage is a multisystemic disease due to its effects on the autonomic nervous system. Pulmonary tissues may be affected due to its effects on the intestinal system, lipid metabolism, and ductus thoracicus in subarachnoid haemorrhage. This study demonstrate the pathophysiology of pulmonary fat embolism after sympathetic activation of the ductus thoracicus with lipid absorption disorders after subarachnoid haemorrhage. Material and Methods: In the study, 24 male rabbits were used, of which five were selected as the control group GI and five as the SHAM group GII. The SHAM group was injected with a 0.7 mL isotonic solution into the cisterna magna. The study group GIII was injected with 0.7 mL autologous blood into the cisterna magna. The lymphatic vessels in the middle sections of the duodenum, the thoracic duct portions opening into the jugular vein, and the terminal branches of the pulmonary arteries were examined and counted. Results: The thoracic duct vasospasm index VSI values and numbers of branches occluded by fat particles in the pulmonary arteries were: 1.650.223.210.54 in GI, 1.970.347.32.4 in GII, and 2.540.5614.5314.53 in GIII. In the six subjects with severe thoracic duct spasm in GIII, the number of pulmonary arteries occluded with chylomicrons was higher p0.00001. P values among groups were: p 0.05 in GIGII; p0.005 in GIIGIII and p0.0001 in GIGIII. Conclusion: This is the first experimental study conducted on animals investigating the lipid metabolism disorder associated with subarachnoid haemorrhage affecting the cervical ganglia, thoracic duct spasm, and pulmonary fat embolism.

 Amaç: Subaraknoid kanama, otonom sinir sistemi üzerindeki etkileri nedeniyle multisistemik bir hastalıktır. Subaraknoid kanamada intestinal sistem, lipid metabolizması ve duktus torasikus üzerindeki etkileri nedeniyle pulmoner dokular etkilenebilir. Bu çalışma, subaraknoid kanamadan sonra lipid emilim bozuklukları ile birlikte duktus torasikusun sempatik aktivasyonundan sonra pulmoner yağ embolisinin patofizyolojisini göstermeyi amaçlamıştır. Gereç ve Yöntem: Çalışmada kullanılan 24 erkek tavşandan beşi kontrol grubu GI, beşi SHAM GII olarak seçildi ve SHAM grubunda sisterna magnaya 0,7 mL izotonik enjekte edildi. Çalışma grubunda GIII ise sisterna magnaya 0,7 mL otolog kan enjekte edildi. Deneklerin duodenum orta kısımlarındaki lenf damarları, juguler vene açılan torasik duktus kısımları ve pulmoner arterlerin terminal dalları incelendi ve sayıldı. Bulgular: Duktus torasikus vazospazm indeks VSI değerleri ve pulmoner arterlerde yağ parçacıkları tarafından tıkanan dal sayıları: GIde 1,650,223,210,54, GIIde 1,970,347,32,4 ve GIIIte 2,540,5614,5314,53 idi. GIIIte şiddetli duktus torasikus spazmı olan altı denekte, şilomikronlarla tıkanmış pulmoner arter sayısı daha yüksekti p0,00001. Gruplar arasındaki p değerleri: GI GIIde p0,05; GIIGIIIte p0,005 ve GIGIIIte p0,0001 idi. Sonuç: Çalışmamız; subaraknoid kanama sonrası gelişen lipid metabolizması bozukluğunun, servikal ganglionlar, duktus torasikus spazmı ve pulmoner yağ embolisi ile ilişkisini araştıran ilk deneysel çalışmadır.

Makale detayları

ROLE OF THE DUCTUS THORACICUS IN PULMONARY FAT EMBOLISM AFTER SUBARACHNOID HAEMORRHAGE: A PRELIMINARY EXPERIMENTAL STUDY

Yazarlar:

Hakan Kına | Muhammet Elveren

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.14-19

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341400

pISSN:

1305-6441

Subarachnoid haemorrhage

thoracic duct

chylomicrons

pulmonary fat embolismSubaraknoid kanama

torasik duktus

şilomikronlar

pulmoner yağ embolisi

Sayı

Makale detayları

Yazarlar: Hakan Kına | Muhammet Elveren

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.14-19

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341400

pISSN: 1305-6441

Sayı

Yazarlar:

Hakan Kına | Muhammet Elveren

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.14-19

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341400

pISSN:

1305-6441