Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

L. B. ZAVODNIK; D. B. VOLOSHIN; A. SKOMOROSHKO; T. N. BUDKO1; V. İ. KONDAKOV; R. N. LIAKH1; A. M. KHOKHA; B. PALECZ

Makale detayları

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Yazarlar:

L. B. ZAVODNIK | D. B. VOLOSHIN | A. SKOMOROSHKO | T. N. BUDKO1 | V. İ. KONDAKOV | R. N. LIAKH1 | A. M. KHOKHA | B. PALECZ

Yayıncı:

İzzet KARA

Dergi:

International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.26-0

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000472118

Sıklık:

Üç Aylık

eISSN:

2148-6905

Özet:

 

Carbon tetrachloride (CCl4) is a known hepatotoxic compound working through the generation of reactive free radicals. Selenium (Se) is an essential trace element required by animals and humans for protection against xenobiotic compounds. In this study, Se, as selenopyran, has been evaluated for its protective action against CCl4-induced hepatotoxicity in Wistar rats. CCl4 exerts its toxic effects by generation of free radicals; it was intraperitoneally administered to male Wistar rats (2g/kg body weight) 24 h before the animals were decapitated. Selenopyran (2mg/kg body weight) was administered intragastrically one month before CCl4 injection. Rats injected with CCl4 alone showed significant lipid and hydropic dystrophy of liver, massive necrosis of hepatocytes, increases in free and conjugated bilirubin levels were marked as well as elevation of hepatic enzymes (alanine aminotransferase and aspartate aminotransferase) in plasma. Selenopyran administered at a pharmacological dose diminished the toxic effects of CCl4. Thus it decreased both the structural and functional injury of hepatocytes and clearly exerted hepatoprotective effects. These findings suggest that the effect of selenopyran on CCl4-induced acute liver injury depends on the antioxidant action Se.

Makale detayları

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Yazarlar: L. B. ZAVODNIK | D. B. VOLOSHIN | A. SKOMOROSHKO | T. N. BUDKO1 | V. İ. KONDAKOV | R. N. LIAKH1 | A. M. KHOKHA | B. PALECZ

Yayıncı: İzzet KARA

Dergi: International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.26-0

Belge Tipi: Makale

Yayın Tarihi: 7/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000472118

Sıklık: Üç Aylık

eISSN: 2148-6905

Sayı

Yazarlar:

L. B. ZAVODNIK | D. B. VOLOSHIN | A. SKOMOROSHKO | T. N. BUDKO1 | V. İ. KONDAKOV | R. N. LIAKH1 | A. M. KHOKHA | B. PALECZ

Yayıncı:

İzzet KARA

Dergi:

International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.26-0

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000472118

Sıklık:

Üç Aylık

eISSN:

2148-6905