Association Angiotensin Converting Enzyme-2 with Lung Cancer

Ayşe Vasfiye Ertuğrul; Gökçen Ömeroğlu Şimşek; Tekincan Çağrı Aktaş; Merve Keskinkılıç; Safiye Aktaş

Makale detayları

Association Angiotensin Converting Enzyme-2 with Lung Cancer

Yazarlar:

Ayşe Vasfiye Ertuğrul | Gökçen Ömeroğlu Şimşek | Tekincan Çağrı Aktaş | Merve Keskinkılıç | Safiye Aktaş

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi Vol.9 Issue 1, pp.81-86

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001310658

pISSN:

2458-9799

Anahtar kelimeler:

Özet:

 Objective: The lung is one of the organs that contain the most angiotensin-converting enzyme 2 ACE-2 receptor. There are very few studies in the literature showing the association between ACE-2 expression and lung cancer. This study aims to investigate the expression of ACE-2 in lung cancer adenocarcinoma and squamous cell lung carcinoma and healthy lung tissue. Material and Method: ACE-2 receptors were studied by immunohistochemistry IHC method in 67 patient tissues diagnosed between 2013 and 2014 in the Bioarchive of Dokuz Eylul University Department of Basic Oncology. ACE-2 expressions were evaluated under a light microscope. Expression values were expressed as percentages . Clinical findings and ACE-2 expression results were evaluated with the statistical method over p0.05. The Kaplan- Meier test evaluated the effect of ACE-2 expression on lung cancer survival. Results: We showed that ACE-2 expression was increased in lung cancer tissues compared to healthy tissues. 2.246.39 95 CI: 1.85  8.39 in healthy tissue, 9.52 17.14 95 CI: 5.90  14.07 in tumor tissue Wilcoxon test; p0.049. ACE2 was highly expressed in lung squamous cell carcinoma LUSC p0.002. Healthy tissue: 2.317.198, Tumor tissue: 15.0621.139. ACE-2 expression was higher in advanced lung adenocarcinoma cases compared to early-stage cases. There was no significant correlation between ACE-2 and EFS event-free survival and OS overall survival. Conclusion: ACE-2 expression was significantly increased in lung cancer tumor tissue compared to healthy tissue. Furthermore, increased ACE-2 expression in squamous cell lung cancer and advanced-stage lung adenocarcinoma compared to early-stage led us to suggest it can potentially be a diagnostic or prognostic lung cancer biomarker. However, more scientific studies are needed.

 Objective: The lung is one of the organs that contain the most angiotensin-converting enzyme 2 ACE-2 receptor. There are very few studies in the literature showing the association between ACE-2 expression and lung cancer. This study aims to investigate the expression of ACE-2 in lung cancer adenocarcinoma and squamous cell lung carcinoma and healthy lung tissue. Material and Method: ACE-2 receptors were studied by immunohistochemistry IHC method in 67 patient tissues diagnosed between 2013 and 2014 in the Bioarchive of Dokuz Eylul University Department of Basic Oncology. ACE-2 expressions were evaluated under a light microscope. Expression values were expressed as percentages . Clinical findings and ACE-2 expression results were evaluated with the statistical method over p0.05. The Kaplan- Meier test evaluated the effect of ACE-2 expression on lung cancer survival. Results: We showed that ACE-2 expression was increased in lung cancer tissues compared to healthy tissues. 2.246.39 95 CI: 1.85  8.39 in healthy tissue, 9.52 17.14 95 CI: 5.90  14.07 in tumor tissue Wilcoxon test; p0.049. ACE2 was highly expressed in lung squamous cell carcinoma LUSC p0.002. Healthy tissue: 2.317.198, Tumor tissue: 15.0621.139. ACE-2 expression was higher in advanced lung adenocarcinoma cases compared to early-stage cases. There was no significant correlation between ACE-2 and EFS event-free survival and OS overall survival. Conclusion: ACE-2 expression was significantly increased in lung cancer tumor tissue compared to healthy tissue. Furthermore, increased ACE-2 expression in squamous cell lung cancer and advanced-stage lung adenocarcinoma compared to early-stage led us to suggest it can potentially be a diagnostic or prognostic lung cancer biomarker. However, more scientific studies are needed.

 Objective: The lung is one of the organs that contain the most angiotensin-converting enzyme 2 ACE-2 receptor. There are very few studies in the literature showing the association between ACE-2 expression and lung cancer. This study aims to investigate the expression of ACE-2 in lung cancer adenocarcinoma and squamous cell lung carcinoma and healthy lung tissue. Material and Method: ACE-2 receptors were studied by immunohistochemistry IHC method in 67 patient tissues diagnosed between 2013 and 2014 in the Bioarchive of Dokuz Eylul University Department of Basic Oncology. ACE-2 expressions were evaluated under a light microscope. Expression values were expressed as percentages . Clinical findings and ACE-2 expression results were evaluated with the statistical method over p0.05. The Kaplan- Meier test evaluated the effect of ACE-2 expression on lung cancer survival. Results: We showed that ACE-2 expression was increased in lung cancer tissues compared to healthy tissues. 2.246.39 95 CI: 1.85  8.39 in healthy tissue, 9.52 17.14 95 CI: 5.90  14.07 in tumor tissue Wilcoxon test; p0.049. ACE2 was highly expressed in lung squamous cell carcinoma LUSC p0.002. Healthy tissue: 2.317.198, Tumor tissue: 15.0621.139. ACE-2 expression was higher in advanced lung adenocarcinoma cases compared to early-stage cases. There was no significant correlation between ACE-2 and EFS event-free survival and OS overall survival. Conclusion: ACE-2 expression was significantly increased in lung cancer tumor tissue compared to healthy tissue. Furthermore, increased ACE-2 expression in squamous cell lung cancer and advanced-stage lung adenocarcinoma compared to early-stage led us to suggest it can potentially be a diagnostic or prognostic lung cancer biomarker. However, more scientific studies are needed.

 Amaç: Akciğer, Anjiotensin konverting enzim 2 ACE-2 reseptörünü en çok bulunduran organlardan birisidir. Literatürde ACE-2 ekspresyonunakciğer kanseri ile ilişkisini gösteren çok az sayıda çalışma bulunmaktadır. Bu çalışmanın amacı, akciğer kanserinde adenokarsinom ve skuamöz hücreli akciğer karsinomunda ve sağlıklı akciğer dokusunda ACE-2 ekspresyon düzeyini araştırmaktır. Gereç ve Yöntem: Dokuz Eylül Üniversitesi Temel Onkoloji Anabilim Dalı Biyoarşivinde bulunan 2013-2014 yılları arasında tanı almış 67 hasta dokusunda immünohistokimya IHC yöntemiyle ACE-2 reseptörleri çalışılmıştır. Ekspresyon yüzde  olarak ışık mikroskobunda değerlendirilmiştir. Klinik bulgular ile ACE2ekspresyonu sonuçları istatistiksel yöntemle p0,05 üzerinden değerlendirilmiştir. Bulgular: Normal doku ile kıyaslandığı zaman akciğer kanserli dokularda ACE-2 ekspresyonunun arttığını kanıtladık. Sağlıklı akciğer dokusunda ortalama ACE-2 ekspresyon yüzdesi 2.246.39 95 CI: 0.68  3.80, tümör dokusunda ortalama ACE-2 ekspresyon yüzdesi 9.52 17.14 95 CI: 5.34 13.70 idi, tümör dokusunda ACE-2 ekspresyonunda anlamlı artış gözlendi p0.049. Tümör dokusunda ACE-2 ekspresyonu skuamöz hücreli akciğer kanserinde sağlıklı dokuya göre anlamlı olarak arttı p0.002 Normal dokuda: 2.31 7.198, Tümöral dokuda: 15.0621.139. ACE-2 ekspresyonunun ileri evre akciğer adenokarsinomu olgularında erken evredeki olgulara göre daha yüksek olduğu saptanmıştır. ACE-2 ile EFS Event-Free Survival; Hastalıksız Sağkalım ve OS overall Survival; Genel Sağkalım arasında anlamlı bir ilişki gösterilememiştir. Sonuç: ACE-2 ekspresyonu akciğer kanseri tümör dokusunda sağlıklı dokuya kıyasla önemli ölçüde artmıştır. Ayrıca, skuamöz hücreli akciğer kanseri ve ileri evre akciğer adenokarsinomunda erken evreye kıyasla artmış ACE-2 ekspresyonu, potansiyel olarak tanısal veya prognostik bir akciğer kanseri biyobelirteci olabileceğini düşünmemize yol açtı. Ancak daha fazla bilimsel çalışmaya ihtiyaç vardır.

Makale detayları

Association Angiotensin Converting Enzyme-2 with Lung Cancer

Yazarlar:

Ayşe Vasfiye Ertuğrul | Gökçen Ömeroğlu Şimşek | Tekincan Çağrı Aktaş | Merve Keskinkılıç | Safiye Aktaş

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi Vol.9 Issue 1, pp.81-86

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001310658

pISSN:

2458-9799

ACE-2

lung cancer

lung squamous cell carcinoma

lung adenocarcinoma

immunohistochemistryACE-2

akciğer kanseri

skuamöz hücreli akciğer kanseri

akciğer adenokarsinom

immunhistokimya.

Sayı

Makale detayları

Yazarlar: Ayşe Vasfiye Ertuğrul | Gökçen Ömeroğlu Şimşek | Tekincan Çağrı Aktaş | Merve Keskinkılıç | Safiye Aktaş

Yayıncı: Izmir Katip Celebi University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi Vol.9 Issue 1, pp.81-86

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001310658

pISSN: 2458-9799

Sayı

Yazarlar:

Ayşe Vasfiye Ertuğrul | Gökçen Ömeroğlu Şimşek | Tekincan Çağrı Aktaş | Merve Keskinkılıç | Safiye Aktaş

Yayıncı:

Izmir Katip Celebi University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi Vol.9 Issue 1, pp.81-86

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001310658

pISSN:

2458-9799