Poplar-Type Propolis Provides Protection of Blood Cells, Testosterone Levels and Sperm Motility in Cisplatin-Induced Toxicity

Abdullah DEMİRTAS; Numan BAYDİLLİ; Gökhan SÖNMEZ; Züleyha DOĞANYİĞİT; Olgay TEKİN; Sibel SİLİCİ

Makale detayları

Poplar-Type Propolis Provides Protection of Blood Cells, Testosterone Levels and Sperm Motility in Cisplatin-Induced Toxicity

Yazarlar:

Abdullah DEMİRTAS | Numan BAYDİLLİ | Gökhan SÖNMEZ | Züleyha DOĞANYİĞİT | Olgay TEKİN | Sibel SİLİCİ

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 4, pp.622-628

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000507322

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483

Özet:

 

Cisplatin is a frequently used chemotherapeutic in many types of cancer, especially urological cancers. Despite its efficacy in the treatment of cancer, it causes various toxic side effects such as nephrotoxicity, neurotoxicity and ototoxicity. The aim of this study was to determine the protective role of olive oile extract of propolis (OEP) with biochemical and histopathological approaches to cisplatin induced toxicity. Sixty-four adult male Wistar rats were divided into eight groups, control, propolis (100 and 200 mg/kg, orally daily for 10 days) and combined therapy (propolis 10 days before and after CP injection). Haematological (Wbc, Rbc, Mpv, Hgb, Htc, Mcv, Mch, Mchc, Lym, Neu), biochemical (triglyceride, total cholesteol, HDL and LDL-cholesterol, glucose, BUN, uric acid and testosterone level), epididymal sperm concentration, sperm motility, and histological studies. According to the results, cisplatin has negative effects on hematological, biochemical parameters, and sperm motility compared to control group. Administration of pre-cisplatin propolis ameliorated wbc, hct, mcv, mchc, neu levels. The administration of OEP prior to CP normalized the increased BUN and uric acid levels induced by CP. Interestingly it was also revealed that the testosterone levels increased in the OEP groups compared to the control group. Additionally, the combined administration of CP with OEP normalized the decreased testosterone levels induced by CP, particularly pre-treatment OEP. As a results, propolis, a natural product with numerous useful biological effects, was shown to a have protective as well as amelioration and normalizing effect on CP-induced damage.

Makale detayları

Poplar-Type Propolis Provides Protection of Blood Cells, Testosterone Levels and Sperm Motility in Cisplatin-Induced Toxicity

Yazarlar: Abdullah DEMİRTAS | Numan BAYDİLLİ | Gökhan SÖNMEZ | Züleyha DOĞANYİĞİT | Olgay TEKİN | Sibel SİLİCİ

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 4, pp.622-628

Belge Tipi: Makale

Yayın Tarihi: 10/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000507322

Sıklık: Üç Aylık

eISSN: 1309-5129

pISSN: 1309-4483

Sayı

Yazarlar:

Abdullah DEMİRTAS | Numan BAYDİLLİ | Gökhan SÖNMEZ | Züleyha DOĞANYİĞİT | Olgay TEKİN | Sibel SİLİCİ

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2021 Vol.38 Issue 4, pp.622-628

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000507322

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483