Effect of the Combination of Glibenclamide, an ATP-dependent Potassium Channel Blocker, and Metoprolol, a Cardioselective b-adrenoceptor Blocker, During Myocardial Infarction in Conscious Rats

Ömer BOZDOĞAN

Makale detayları

Effect of the Combination of Glibenclamide, an ATP-dependent Potassium Channel Blocker, and Metoprolol, a Cardioselective b-adrenoceptor Blocker, During Myocardial Infarction in Conscious Rats

Yazarlar:

Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.517-522

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

İngilizce

Document ID (Org No.):

2000757453

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

We investigated the possible  interaction of glibenclamide and metoprolol  on the occurrence of life threatening  arrhythmias during the acute phase of  experimental myocardial infarction. Coronary  artery ligation was performed in conscious  rats and ECG was recorded for 15 min  following ligation. Neither metoprolol (2  mg/kg i.p., 20 min before coronary artery  ligation), nor glibenclamide (5 mg/kg i.p., 30  min before ligation) pretreatment increased  significantly the survival rate during the acute  phase of myocardial infarction (10 % and 22  %, respectively vs. 9 % in controls).  Combination of glibenclamide with  metoprolol, however, significantly improved  the survival rate (62 %, P < 0.05). These  results suggest that the combination of a  cardioselective b-blocking agent with an ATP-  dependent potassium channel inhibitor may  result in an enhanced antiarrhythmic effect  during the acute phase of myocardial  infarction.

 

We investigated the possible  interaction of glibenclamide and metoprolol  on the occurrence of life threatening  arrhythmias during the acute phase of  experimental myocardial infarction. Coronary  artery ligation was performed in conscious  rats and ECG was recorded for 15 min  following ligation. Neither metoprolol (2  mg/kg i.p., 20 min before coronary artery  ligation), nor glibenclamide (5 mg/kg i.p., 30  min before ligation) pretreatment increased  significantly the survival rate during the acute  phase of myocardial infarction (10 % and 22  %, respectively vs. 9 % in controls).  Combination of glibenclamide with  metoprolol, however, significantly improved  the survival rate (62 %, P < 0.05). These  results suggest that the combination of a  cardioselective b-blocking agent with an ATP-  dependent potassium channel inhibitor may  result in an enhanced antiarrhythmic effect  during the acute phase of myocardial  infarction.

Makale detayları

Effect of the Combination of Glibenclamide, an ATP-dependent Potassium Channel Blocker, and Metoprolol, a Cardioselective b-adrenoceptor Blocker, During Myocardial Infarction in Conscious Rats

Yazarlar:

Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.517-522

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

İngilizce

Document ID (Org No.):

2000757453

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Glibenclamide

Metoprolol

Arrhythmias

Sudden cardiac death

Conscious rats

Sayı

Makale detayları

Effect of the Combination of Glibenclamide, an ATP-dependent Potassium Channel Blocker, and Metoprolol, a Cardioselective b-adrenoceptor Blocker, During Myocardial Infarction in Conscious Rats

Yazarlar: Ömer BOZDOĞAN

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.517-522

Belge Tipi: Makale

Yayın Tarihi: 5/2000

Belge Dili: İngilizce

Document ID (Org No.): 2000757453

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Glibenclamide

Metoprolol

Arrhythmias

Sudden cardiac death

Conscious rats

Sayı

Yazarlar:

Ömer BOZDOĞAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.517-522

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

İngilizce

Document ID (Org No.):

2000757453

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144