Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases

İdris Kırhan; Aliye Gamze Çalış; Fatih Üzer; Bedia Karaçadır; Hamdiye Turan

Makale detayları

Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases

Yazarlar:

İdris Kırhan | Aliye Gamze Çalış | Fatih Üzer | Bedia Karaçadır | Hamdiye Turan

Yayıncı:

Harran University

Ana Başlıklar:

Solunum Hastalıkları | Göğüs Hastalıkları

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.351-356

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343955

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: This study aimed to evaluate pleural fluid gas parameters in patients with different underl-ying pulmonary diseases to assess their diagnostic implications. Materials and Methods: This study conducted at Akdeniz University Pulmonology Department and Har-ran University Pulmonology Department. The retrospective study included 118 patients with pleural effusion confirmed via imaging between January 2018 and December 2024. Pleural fluid samples collec-ted by thoracentesis underwent gas analysis pO₂, pCO₂, pH, HCO₃ and standard biochemical and cytolo-gical evaluations. Comparative analysis of gas characteristics was performed across diagnostic categories with a significance threshold of p  0.05. Results: In this study, 87 of 118 patients underwent arterial blood gas analysis, with a mean age of 66.414.2 years and 72.4 being male. Acidic, normal, and alkaline pleural fluid pH values were obser-ved in 25.3, 26.4, and 48.3 of patients, respectively. Most effusions were exudative 83.9, and unilateral 81.6, with malignancy 29.9, pneumonia 35.6, and heart failure 16.1 being the leading causes. Among pneumonia cases, 45.1 had complicated effusions or empyema. Transudative effusions were associated with older age, higher pH, and lower LDH, pCO₂, and protein levels p0.05. Compared to other causes, pneumonia-related effusions were more likely to be exudative, occur in males, and have higher protein levels. Malignant effusions showed significantly higher HCO₃ and protein levels p0.05. Conclusions: Pleural fluid gas analysis may offer valuable diagnostic insights, particularly in differentia-ting infectious from non-infectious effusions.

 Background: This study aimed to evaluate pleural fluid gas parameters in patients with different underl-ying pulmonary diseases to assess their diagnostic implications. Materials and Methods: This study conducted at Akdeniz University Pulmonology Department and Har-ran University Pulmonology Department. The retrospective study included 118 patients with pleural effusion confirmed via imaging between January 2018 and December 2024. Pleural fluid samples collec-ted by thoracentesis underwent gas analysis pO₂, pCO₂, pH, HCO₃ and standard biochemical and cytolo-gical evaluations. Comparative analysis of gas characteristics was performed across diagnostic categories with a significance threshold of p  0.05. Results: In this study, 87 of 118 patients underwent arterial blood gas analysis, with a mean age of 66.414.2 years and 72.4 being male. Acidic, normal, and alkaline pleural fluid pH values were obser-ved in 25.3, 26.4, and 48.3 of patients, respectively. Most effusions were exudative 83.9, and unilateral 81.6, with malignancy 29.9, pneumonia 35.6, and heart failure 16.1 being the leading causes. Among pneumonia cases, 45.1 had complicated effusions or empyema. Transudative effusions were associated with older age, higher pH, and lower LDH, pCO₂, and protein levels p0.05. Compared to other causes, pneumonia-related effusions were more likely to be exudative, occur in males, and have higher protein levels. Malignant effusions showed significantly higher HCO₃ and protein levels p0.05. Conclusions: Pleural fluid gas analysis may offer valuable diagnostic insights, particularly in differentia-ting infectious from non-infectious effusions.

 Background: This study aimed to evaluate pleural fluid gas parameters in patients with different underl-ying pulmonary diseases to assess their diagnostic implications. Materials and Methods: This study conducted at Akdeniz University Pulmonology Department and Har-ran University Pulmonology Department. The retrospective study included 118 patients with pleural effusion confirmed via imaging between January 2018 and December 2024. Pleural fluid samples collec-ted by thoracentesis underwent gas analysis pO₂, pCO₂, pH, HCO₃ and standard biochemical and cytolo-gical evaluations. Comparative analysis of gas characteristics was performed across diagnostic categories with a significance threshold of p  0.05. Results: In this study, 87 of 118 patients underwent arterial blood gas analysis, with a mean age of 66.414.2 years and 72.4 being male. Acidic, normal, and alkaline pleural fluid pH values were obser-ved in 25.3, 26.4, and 48.3 of patients, respectively. Most effusions were exudative 83.9, and unilateral 81.6, with malignancy 29.9, pneumonia 35.6, and heart failure 16.1 being the leading causes. Among pneumonia cases, 45.1 had complicated effusions or empyema. Transudative effusions were associated with older age, higher pH, and lower LDH, pCO₂, and protein levels p0.05. Compared to other causes, pneumonia-related effusions were more likely to be exudative, occur in males, and have higher protein levels. Malignant effusions showed significantly higher HCO₃ and protein levels p0.05. Conclusions: Pleural fluid gas analysis may offer valuable diagnostic insights, particularly in differentia-ting infectious from non-infectious effusions.

 Amaç: Bu çalışma, farklı altta yatan pulmoner hastalıkları olan hastalarda plevral sıvı gaz parametrelerini değerlendirerek tanısal etkilerini incelemeyi amaçlamaktadır. Materyal ve Metod: Akdeniz Üniversitesi ve Harran Üniversitesi Göğüs Hastalıkları Bölümünde gerçek-leştirilen bu retrospektif çalışma, Ocak 2018 ile Aralık 2022 arasında görüntüleme ile doğrulanmış plev-ral efüzyonu olan 118 hastayı içermektedir. Torasentez ile toplanan plevral sıvı örneklerine gaz analizi pO₂, pCO₂, pH, HCO₃ ve standart biyokimyasal ve sitolojik değerlendirmeler yapıldı. Gaz özellikleri, tanı kategorileri arasında karşılaştırmalı olarak analiz edildi ve anlamlılık eşiği p  0,05 olarak belirlendi. Bulgular: Bu çalışmada, 118 hastanın 87sine arteriyel kan gazı analizi uygulandı; hastaların ortalama yaşı 66,414,2 yıl olup, 72,4ü erkekti. Plevral sıvı pH değeri hastaların 25,3ünde asidik, 26,4ünde normal ve 48,3ünde alkalen olarak saptandı. Plevral sıvıların büyük çoğunluğu 83,9 eksüdatif ve 81,6sı unilateraldı. En sık nedenler malignite 29,9, pnömoni 35,6 ve kalp yetmezliği 16,1 olarak belirlendi. Pnömoni tanısı alan olguların 45,1inde komplike efüzyon veya ampiyem vardı. Tran-südatif efüzyonlar daha ileri yaş, daha yüksek pH ve daha düşük LDH, pCO₂ ve protein düzeyleri ile ilişki-liydi p0,05. Pnömoniye bağlı efüzyonlar, diğer nedenlere kıyasla daha çok erkeklerde görülmekte, daha yüksek protein düzeylerine sahip olmakta ve daha sık eksüdatif özellik göstermekteydi. Malignite grubunda ise HCO₃ ve total protein düzeyleri anlamlı olarak daha yüksekti p0,05. Sonuç: Plevral sıvı gaz analizi, özellikle enfeksiyöz ve enfeksiyöz olmayan efüzyonları ayırt etmede yararlı tanısal bilgiler sunabilir.

Makale detayları

Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases

Yazarlar:

İdris Kırhan | Aliye Gamze Çalış | Fatih Üzer | Bedia Karaçadır | Hamdiye Turan

Yayıncı:

Harran University

Ana Başlıklar:

Solunum Hastalıkları | Göğüs Hastalıkları

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.351-356

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343955

pISSN:

1304-9623

Pleural Fluid Analysis

Pneumonia

Pulmonary Diseasesplevral efüzyon

pnömoni

pulmoner hastalıklar

Sayı

Makale detayları

Pleural Fluid Gas Analysis in Diagnosing and Differentiating Pulmonary Diseases

Yazarlar: İdris Kırhan | Aliye Gamze Çalış | Fatih Üzer | Bedia Karaçadır | Hamdiye Turan

Yayıncı: Harran University

Ana Başlıklar: Solunum Hastalıkları | Göğüs Hastalıkları

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.351-356

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343955

pISSN: 1304-9623

Pleural Fluid Analysis

Pneumonia

Pulmonary Diseasesplevral efüzyon

pnömoni

pulmoner hastalıklar

Sayı

Yazarlar:

İdris Kırhan | Aliye Gamze Çalış | Fatih Üzer | Bedia Karaçadır | Hamdiye Turan

Yayıncı:

Harran University

Ana Başlıklar:

Solunum Hastalıkları | Göğüs Hastalıkları

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 2, pp.351-356

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343955

pISSN:

1304-9623