Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

Rajendra Awasthi

Makale detayları

Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

Yazarlar:

Rajendra Awasthi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.249-258

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346178

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID 244 FP. The poorly soluble drug atorvastatin was adsorbed on andor into SYLOID 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID 244 FP is done by Fourier-transform infrared spectroscopy FTIR and differential scanning calorimetry DSC. The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carrs index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables - volume of ethanol and amount of SYLOID 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.

 The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID 244 FP. The poorly soluble drug atorvastatin was adsorbed on andor into SYLOID 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID 244 FP is done by Fourier-transform infrared spectroscopy FTIR and differential scanning calorimetry DSC. The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carrs index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables - volume of ethanol and amount of SYLOID 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.

 The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID 244 FP. The poorly soluble drug atorvastatin was adsorbed on andor into SYLOID 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID 244 FP is done by Fourier-transform infrared spectroscopy FTIR and differential scanning calorimetry DSC. The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carrs index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables - volume of ethanol and amount of SYLOID 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.

 The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID 244 FP. The poorly soluble drug atorvastatin was adsorbed on andor into SYLOID 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID 244 FP is done by Fourier-transform infrared spectroscopy FTIR and differential scanning calorimetry DSC. The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carrs index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables - volume of ethanol and amount of SYLOID 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.

Makale detayları

Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

Yazarlar:

Rajendra Awasthi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.249-258

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346178

pISSN:

2630-6344

Non-ordered mesoporous silica

atorvastatin

wetness impregnation method

factorial design

bioavailability

Sayı

Makale detayları

Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

Yazarlar: Rajendra Awasthi

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.22 Issue 2, pp.249-258

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346178

pISSN: 2630-6344

Non-ordered mesoporous silica

atorvastatin

wetness impregnation method

factorial design

bioavailability

Sayı

Yazarlar:

Rajendra Awasthi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.22 Issue 2, pp.249-258

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346178

pISSN:

2630-6344