The Relationship Between Blood Parameters, Sleep, Anxiety and Depression Symptoms: A Retrospective Polysomnography Study

Fettah Eren; Faysal Duksal

Makale detayları

The Relationship Between Blood Parameters, Sleep, Anxiety and Depression Symptoms: A Retrospective Polysomnography Study

Yazarlar:

Fettah Eren | Faysal Duksal

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.541-547

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301342

pISSN:

2602-3741

Anahtar kelimeler:

Özet:

 Objective: It is known that anxiety and depression are associated with sleep disorders and many systemic diseases. This study aims to analyse the relationship between anxiety, depression symptoms and sleep parameters among the patients subjected to polysomnographic recording. Material and Methods: A total of 808 patients who were subjected to a polysomnographic recording were included in the retrospective cross-sectional and hospital-based study. Body mass index BMI was calculated. Anxiety and depression symptoms were evaluated using the Beck anxiety and Beck depression inventory. Patients were divided into groups according to anxiety and depression scores. The apnoea hypopnea index AHI, oxygen desaturation index ODI, and peripheral oxygen saturation SaO2 were obtained from the polysomnographic recordings. Results: In the study, there were 528 65.3 male and 280 34.7 female patients with the mean age 47.64  12.25 18-82. Depression was detected in 307 38.0 patients according to Beck depression score. Mild anxiety symptoms were detected in 516 63.9, moderate anxiety symptoms in 215 26.6 patients and severe anxiety symptoms in 77 9.5 patients according to Beck anxiety score. There was a statistical difference for all polysomnographic parameters in depression and anxiety severity groups p0.001. In patients with depression had lower free-T3 and higher C-reactive protein CRP levels p0.001, p0.014. The difference between thyroid stimulating hormone TSH and FT4 levels was determined according to the severity of the depression p0.037, p0.047. CRP was higher in patients with severe anxiety p0.008; and free-T3 was lower in patients with moderate and severe anxiety p0.003, p0.001. In the logistic regression analysis, free-T3, minimum SaO2 and BMI had an impact on anxiety p0.002, p0.033, p0.031 and depression p0.001, p0.017, p0.035. Conclusion: Anxiety and depression symptoms are affected by numerous factors, especially sleep characteristics. Minimum SaO2, CRP and free-T3 are main predisposing factors on anxiety and depression.

 Objective: It is known that anxiety and depression are associated with sleep disorders and many systemic diseases. This study aims to analyse the relationship between anxiety, depression symptoms and sleep parameters among the patients subjected to polysomnographic recording. Material and Methods: A total of 808 patients who were subjected to a polysomnographic recording were included in the retrospective cross-sectional and hospital-based study. Body mass index BMI was calculated. Anxiety and depression symptoms were evaluated using the Beck anxiety and Beck depression inventory. Patients were divided into groups according to anxiety and depression scores. The apnoea hypopnea index AHI, oxygen desaturation index ODI, and peripheral oxygen saturation SaO2 were obtained from the polysomnographic recordings. Results: In the study, there were 528 65.3 male and 280 34.7 female patients with the mean age 47.64  12.25 18-82. Depression was detected in 307 38.0 patients according to Beck depression score. Mild anxiety symptoms were detected in 516 63.9, moderate anxiety symptoms in 215 26.6 patients and severe anxiety symptoms in 77 9.5 patients according to Beck anxiety score. There was a statistical difference for all polysomnographic parameters in depression and anxiety severity groups p0.001. In patients with depression had lower free-T3 and higher C-reactive protein CRP levels p0.001, p0.014. The difference between thyroid stimulating hormone TSH and FT4 levels was determined according to the severity of the depression p0.037, p0.047. CRP was higher in patients with severe anxiety p0.008; and free-T3 was lower in patients with moderate and severe anxiety p0.003, p0.001. In the logistic regression analysis, free-T3, minimum SaO2 and BMI had an impact on anxiety p0.002, p0.033, p0.031 and depression p0.001, p0.017, p0.035. Conclusion: Anxiety and depression symptoms are affected by numerous factors, especially sleep characteristics. Minimum SaO2, CRP and free-T3 are main predisposing factors on anxiety and depression.

 Objective: It is known that anxiety and depression are associated with sleep disorders and many systemic diseases. This study aims to analyse the relationship between anxiety, depression symptoms and sleep parameters among the patients subjected to polysomnographic recording. Material and Methods: A total of 808 patients who were subjected to a polysomnographic recording were included in the retrospective cross-sectional and hospital-based study. Body mass index BMI was calculated. Anxiety and depression symptoms were evaluated using the Beck anxiety and Beck depression inventory. Patients were divided into groups according to anxiety and depression scores. The apnoea hypopnea index AHI, oxygen desaturation index ODI, and peripheral oxygen saturation SaO2 were obtained from the polysomnographic recordings. Results: In the study, there were 528 65.3 male and 280 34.7 female patients with the mean age 47.64  12.25 18-82. Depression was detected in 307 38.0 patients according to Beck depression score. Mild anxiety symptoms were detected in 516 63.9, moderate anxiety symptoms in 215 26.6 patients and severe anxiety symptoms in 77 9.5 patients according to Beck anxiety score. There was a statistical difference for all polysomnographic parameters in depression and anxiety severity groups p0.001. In patients with depression had lower free-T3 and higher C-reactive protein CRP levels p0.001, p0.014. The difference between thyroid stimulating hormone TSH and FT4 levels was determined according to the severity of the depression p0.037, p0.047. CRP was higher in patients with severe anxiety p0.008; and free-T3 was lower in patients with moderate and severe anxiety p0.003, p0.001. In the logistic regression analysis, free-T3, minimum SaO2 and BMI had an impact on anxiety p0.002, p0.033, p0.031 and depression p0.001, p0.017, p0.035. Conclusion: Anxiety and depression symptoms are affected by numerous factors, especially sleep characteristics. Minimum SaO2, CRP and free-T3 are main predisposing factors on anxiety and depression.

 Amaç: Anksiyete ve depresyonun uyku bozukluklaru ve birçok sistemik hastalık ile ilişkili olduğu bilinmektedir. Bu çalışmada polisomnografik kayıtlaması yapılan hastalarda anksiyete ve depresyonun uyku sırasındaki hipoksi, inflamasyon ve tiroid fonksiyonları ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Retrospektif kesitsel, hastane tabanlı çalışmaya polisomnografi kaydı yapılan 808 hasta dahil edildi. Vücut kitle indeksi VKI hesaplandı. Anksiyete ve depresyon Beck anksiyete ve Beck depresyon envanteri ile değerlendirildi. Hastalar anksiyete ve depresyon skorlarına göre gruplara ayrıldı. Polisomnografi kayıtlarından apne hipopne indeksi AHI, oksijen desaturasyonu indeksi ODI, ve periferik oksijen saturasyonu SaO2 elde edildi. Bulgular: Çalışmada yaş ortalaması 47,64  12,25 18-82 yıl olan 528 65,3 erkek ve 280 34,7 kadın hasta vardı. Üç yüz yedi 38,0 hastada depresyon saptandı. Hastaların 516 63,9 sında hafif, 215 26,6 inde orta ve 77 9,5sinde ciddi derecede anksiyete vardı. Depresyon ve anksiyete şiddeti grupları ile tüm polisomnografi parametreleri arasında fark vardı p0.001. Depresyon hastalarında serbest-T3 daha düşük, C-reaktif protein CRP daha yüksekti p0.001, p0.014. Depresyon şiddetine göre TSH ve FT4 seviyesi farkı belirlendi p0.037, p0.047. Şiddetli anksiyetede CRP yüksek, orta ve şiddetli anksiyetede serbest-T3 daha düşüktü p0.008, p0.003, p0.001. Lojistik regresyon analizinde serbest-T3, minimum SaO2 ve VKI değerlerinin anksiyete p0.002, p0.033, p0.031 ve depresyon p0.001, p0.017, p0.035 üzerinde etkisi vardı. Sonuç: Anksiyete ve depresyon uyku karakteri başta olmak üzere birçok faktörden etkilenmektedir. Özellikle minimum SaO2, CRP ve serbest-T3 bunların başında gelmektedir.

Makale detayları

The Relationship Between Blood Parameters, Sleep, Anxiety and Depression Symptoms: A Retrospective Polysomnography Study

Yazarlar:

Fettah Eren | Faysal Duksal

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.541-547

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301342

pISSN:

2602-3741

Anxiety

depression

sleep

inflammation

thyroid functionAnksiyete

depresyon

uyku

inflamasyon

tiroid fonksiyonu

Sayı

Makale detayları

Yazarlar: Fettah Eren | Faysal Duksal

Yayıncı: Selcuk University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Genel Tıp Dergisi Vol.33 Issue 5, pp.541-547

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001301342

pISSN: 2602-3741

Sayı

Yazarlar:

Fettah Eren | Faysal Duksal

Yayıncı:

Selcuk University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Genel Tıp Dergisi Vol.33 Issue 5, pp.541-547

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301342

pISSN:

2602-3741