Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

N.A.

Makale detayları

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1056-1064

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347901

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Musa paradisiaca stem juice MPSJ found an extensive use in folklore medicine, but its antiepileptic properties are yet to be scientifically proven, hence, the aim of this study. Pentylenetetrazole PTZ-induced seizure model was adopted, involving twenty-four n24 adult male albino rats, randomly distributed into six 6 groups of four animals each n4. Group 1 received saline p.o; group 2 was untreated; group 3 received 4 mgkg b.w diazepam p.o; while groups 4, 5 and 6 received 50, 75 and 100 vv of MPSJ p.o, respectively. The treatment lasted for 10 days before rats were challenged with PTZ 85 mgkg b.w, i.p after 45 min. Group 6 showed a significant p  0.05 increase in brain GABA level compared to that of the untreated group. Groups 5 and 6 showed a significant p  0.05 reduction in glutamate level and GABA-T activities compared to that of group 2. There were significant p  0.05 increases in the levels of CAT and SOD of group 6 rats compared to those of the untreated groups, except the GSH that was not statistically significant p  0.05. Group 6 showed a significantly p  0.05 higher SOD concentration when compared to group 2. The MDA level of group 4 was significantly p  0.05 reduced compared to that of group 2. The neuronal necrosis produced by PTZ was ameliorated in group 4 rats and the normal histo-architecture of the brain was restored. This study suggests MPSJ has protective effects against PTZ-induced seizures in rats.

 Musa paradisiaca stem juice MPSJ found an extensive use in folklore medicine, but its antiepileptic properties are yet to be scientifically proven, hence, the aim of this study. Pentylenetetrazole PTZ-induced seizure model was adopted, involving twenty-four n24 adult male albino rats, randomly distributed into six 6 groups of four animals each n4. Group 1 received saline p.o; group 2 was untreated; group 3 received 4 mgkg b.w diazepam p.o; while groups 4, 5 and 6 received 50, 75 and 100 vv of MPSJ p.o, respectively. The treatment lasted for 10 days before rats were challenged with PTZ 85 mgkg b.w, i.p after 45 min. Group 6 showed a significant p  0.05 increase in brain GABA level compared to that of the untreated group. Groups 5 and 6 showed a significant p  0.05 reduction in glutamate level and GABA-T activities compared to that of group 2. There were significant p  0.05 increases in the levels of CAT and SOD of group 6 rats compared to those of the untreated groups, except the GSH that was not statistically significant p  0.05. Group 6 showed a significantly p  0.05 higher SOD concentration when compared to group 2. The MDA level of group 4 was significantly p  0.05 reduced compared to that of group 2. The neuronal necrosis produced by PTZ was ameliorated in group 4 rats and the normal histo-architecture of the brain was restored. This study suggests MPSJ has protective effects against PTZ-induced seizures in rats.

 Musa paradisiaca stem juice MPSJ found an extensive use in folklore medicine, but its antiepileptic properties are yet to be scientifically proven, hence, the aim of this study. Pentylenetetrazole PTZ-induced seizure model was adopted, involving twenty-four n24 adult male albino rats, randomly distributed into six 6 groups of four animals each n4. Group 1 received saline p.o; group 2 was untreated; group 3 received 4 mgkg b.w diazepam p.o; while groups 4, 5 and 6 received 50, 75 and 100 vv of MPSJ p.o, respectively. The treatment lasted for 10 days before rats were challenged with PTZ 85 mgkg b.w, i.p after 45 min. Group 6 showed a significant p  0.05 increase in brain GABA level compared to that of the untreated group. Groups 5 and 6 showed a significant p  0.05 reduction in glutamate level and GABA-T activities compared to that of group 2. There were significant p  0.05 increases in the levels of CAT and SOD of group 6 rats compared to those of the untreated groups, except the GSH that was not statistically significant p  0.05. Group 6 showed a significantly p  0.05 higher SOD concentration when compared to group 2. The MDA level of group 4 was significantly p  0.05 reduced compared to that of group 2. The neuronal necrosis produced by PTZ was ameliorated in group 4 rats and the normal histo-architecture of the brain was restored. This study suggests MPSJ has protective effects against PTZ-induced seizures in rats.

 Musa paradisiaca stem juice MPSJ found an extensive use in folklore medicine, but its antiepileptic properties are yet to be scientifically proven, hence, the aim of this study. Pentylenetetrazole PTZ-induced seizure model was adopted, involving twenty-four n24 adult male albino rats, randomly distributed into six 6 groups of four animals each n4. Group 1 received saline p.o; group 2 was untreated; group 3 received 4 mgkg b.w diazepam p.o; while groups 4, 5 and 6 received 50, 75 and 100 vv of MPSJ p.o, respectively. The treatment lasted for 10 days before rats were challenged with PTZ 85 mgkg b.w, i.p after 45 min. Group 6 showed a significant p  0.05 increase in brain GABA level compared to that of the untreated group. Groups 5 and 6 showed a significant p  0.05 reduction in glutamate level and GABA-T activities compared to that of group 2. There were significant p  0.05 increases in the levels of CAT and SOD of group 6 rats compared to those of the untreated groups, except the GSH that was not statistically significant p  0.05. Group 6 showed a significantly p  0.05 higher SOD concentration when compared to group 2. The MDA level of group 4 was significantly p  0.05 reduced compared to that of group 2. The neuronal necrosis produced by PTZ was ameliorated in group 4 rats and the normal histo-architecture of the brain was restored. This study suggests MPSJ has protective effects against PTZ-induced seizures in rats.

Makale detayları

Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1056-1064

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347901

pISSN:

2630-6344

Seizure disorder

convulsion

Plantain (Musa paradisiaca)

pentylenetetrazole

neurotransmitter

GABAT

antioxidant

Sayı

Makale detayları

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biochemistry

Dergi: Journal of Research in Pharmacy Vol.27 Issue 3, pp.1056-1064

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347901

pISSN: 2630-6344

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1056-1064

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347901

pISSN:

2630-6344